antibiotics Flashcards
treatment of histoplasmosis
itraconazole
class and mechanism of aztreonam
monobactam that is resistant to beta lactamases; blocks cell wall synthesis by preventing peptidoglycan cross-linking by binding penicillin binding protein 3 (PBP3)
true or false. monobactams are associated with cross-reactivity in penicillin allergic patients
false
true or false. aztreonam can be used for gram negative intraabdominal infections
true
ceftriaxone class and mechanism of action
beta lactam; inhibits cell wall synthesis
true or false. ceftriaxone does not provide good gram negative coverage
false
ciprofloxacin mechanism of action
inhibits DNA gyrase and topoisomerase IV
true or false. ciprofloxacin provides good gram negative coverage
true
metronidazole mechanism of action
forms free radical toxic metabolites in the bacterial cell that damages DNA
true or false. metronidazole provides good gram negative and anaerobe coverage
true
tetracycline mechanism of action
blocks protein synthesis at the 30s ribosomal subunit
true or false. tetracycline provides good gram positive and negative coverage
true
recommended treatment for community-acquired SBP
third generation cephalosporin or zosyn
recommended treatment for hospital-acquired SBP
carbapenem +/- daptomycin
Bacterial endotoxin, which is composed of lipopolysaccaharide (LPS), is an intrinsic component of the outer membrane of which type of bacteria
gram negative bacteria
The backbone domain of LPS is ____ - a potent stimulator of proinflammatory cytokines, acute phase reactants, and nitric oxide synthetase
lipid A
