Cell proliferation and death, cytokines and signalling Flashcards
Apoptosis
Programmed cell death
Necrosis
lethal cell injury or accidental cell death
Characteristics of apoptosis
- Can be a physiological or pathological process
- Membrane integrity is maintained
- Cell shrinkage occurs
- There are characteristic nuclear changes e.g. DNA cleavage
- Formation of apoptotic bodies
- Activation of specific caspace proteases
Characteristics of necrosis
- Always a pathological process
- Membrane integrity is lost
- Cell swelling occurs
- Loss of cell nuclei
- Leakage of lysosomal enzymes
Mutagenesis
The production of genetic mutations
Oncogenesis
The development of a tumour
Neoplasia
abnormal proliferation of cells
Characteristics of benign tumours
- No metastasis
- Good demarcation from surrounding tissues
- Well differentiated mass
- Low mitotic rate
- Minimal nuclear or cell pleomorphism
Characteristics of malignant tumours
- Frequent metastasis
- Invades surrounding tissues, blood and lymphatic vessels
- Disorganisation of tissue
- High mitotic rate
- Increased nuclear or cell pleomorphism
Why is cell signalling important?
Required for:
- Movement
- Growth
- Metabolism
- Development
- Immune response
How is signal specificity achieved?
- Sometimes cell-to-cell contact is required
- Sometimes specific receptors are required; only certain cells/under certain conditions will express the protein for a receptor
Autocrine
self-signalling; direct feedback on the cell that provduced the signal.
Paracrine
the signal has an effect on a cell nearby.
Endocrine
the effect is on a distant cell. The signalling molecules travel in the bloodstream.
Cytokines
soluble proteins or glycoproteins produced by cells. Important signalling molecules, esp. in inflammation and innate immunity.