Cell Mediated (Specific) Response Flashcards

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1
Q

what cells are involved in the cell mediated response?

A

T cells

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2
Q

briefly describe what happens in the cell mediated response

A
  • receptors on T cells bind to antigens on antigen presenting cells
  • T cells divide rapidly by mitosis (clonal expansion)
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3
Q

state 4 examples of antigen presenting cells

A
  • infected body cells with viral antigens
  • macrophages which have engulfed and destroyed a pathogen
  • transplanted organ cells
  • cancer cells with abnormal shaped antigens
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4
Q

stage 1 (APC)

A

after being engulfed and destroyed in phagocytosis, the cell is antigen presenting

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5
Q

stage 2 (receptors)

A

T helper cells receptors attach to antigens of APCs

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6
Q

stage 3 (interleukins)

A

interleukins are produced, activating T helper cells to rapidly divide by mitosis - clonal expansion

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7
Q

stage 4 (differentiation)

A

cloned T helper cells differentiate:
- T memory cells
- T killer cells
- T regulatory cells

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8
Q

what are T regulator cells?

A

suppress immune response so that cell mediated response only occurs when pathogens are detected

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9
Q

state 2 examples of T helper differentiation in terms of interleukins

A
  • produce interleukins to activate B lymphocytes
  • produce interleukins to stimulate macrophages
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10
Q

describe T killer cells

A
  • destroy abnormal/infected cells
  • release perforin which embeds in pathogen cell membrane aand creates a pore; allows substances to exit and enter, causing cell death
  • common in viral replication
  • body cells are sacrificed to prevent viral replication
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