Cell Mediated (Specific) Response Flashcards
what cells are involved in the cell mediated response?
T cells
briefly describe what happens in the cell mediated response
- receptors on T cells bind to antigens on antigen presenting cells
- T cells divide rapidly by mitosis (clonal expansion)
state 4 examples of antigen presenting cells
- infected body cells with viral antigens
- macrophages which have engulfed and destroyed a pathogen
- transplanted organ cells
- cancer cells with abnormal shaped antigens
stage 1 (APC)
after being engulfed and destroyed in phagocytosis, the cell is antigen presenting
stage 2 (receptors)
T helper cells receptors attach to antigens of APCs
stage 3 (interleukins)
interleukins are produced, activating T helper cells to rapidly divide by mitosis - clonal expansion
stage 4 (differentiation)
cloned T helper cells differentiate:
- T memory cells
- T killer cells
- T regulatory cells
what are T regulator cells?
suppress immune response so that cell mediated response only occurs when pathogens are detected
state 2 examples of T helper differentiation in terms of interleukins
- produce interleukins to activate B lymphocytes
- produce interleukins to stimulate macrophages
describe T killer cells
- destroy abnormal/infected cells
- release perforin which embeds in pathogen cell membrane aand creates a pore; allows substances to exit and enter, causing cell death
- common in viral replication
- body cells are sacrificed to prevent viral replication