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USMLE STEP 1 > Cell Markers > Flashcards

Cell Markers Flashcards

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USMLE® Step 1 flashcards
1
Q

Reed Sternberg markers

A

CD15+, CD30+

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2
Q

CD10+ cancers

A

Acute lymphoblastic leukemia (ALL)

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3
Q

Amyloid (AA)- type and location/syndrome

A

Secondary amyloidosis; kidney (frequent), liver, spleen

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4
Q

Amyloid beta- type and location/syndrome

A

Alzheimer’s; dementia

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5
Q

Transthyretin (aka prealbumin, TTR)

A

Senile cardiac amyloidosis (asymptomatic) or restrictive cardiomyopathy if mutated

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6
Q

Amylin deposits

A

Type II diabetes in islets of the pancreas

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7
Q

Beta2-microglobulin amyloidosis

A

Dialysis-associated amyloidosis

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8
Q

Calcitonin deposits (“tumor cells in amyloid background”)

A

Medullary carcinoma of the thyroid

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9
Q

Amyloid light chain

A

Systemic amyloidosis, including heart and kidney. Associated with plasma cell dyscrasias (e.g. multiple myeloma)

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10
Q

CD11c cancer(s)

A

Hairy cell leukemia, Langerhans cell histiocytosis

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11
Q

CD20 cancer(s)

A

L&H “popcorn” RS variants (lymphocyte-predominant HL), most B cell leukemias/lymphomas

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12
Q

CD25 cancer(s)

A

Hairy cell leukemia

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13
Q

CD33 cancer(s)

A

Acute myelogenous leukemia (AML)

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14
Q

CD55 (DAF) pathology

A

Low levels in paroxysmal nocturnal hemoglobinuria

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15
Q

MALT lymphoma markers

A

CD20+, CD5-, CD10-

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16
Q

GIST markers

A

c-kit (CD117)+, PGDFRA+ (only in treatment-sensitive cancers)

17
Q

Pdx1

A

Pancreatic epithelial cells

18
Q

E-cadherin

A

Epithelial cell

19
Q

Alpha-fetoprotein (AFP)

A

Hepatocellular carcinoma, non-seminomatous germ cell tumors

20
Q

Beta-human chorionic gonadotropic (hCG)

A

Trophoblastic tumors

21
Q

Calcitonin

A

Medullary carcinoma of the thyroid

22
Q

Carcinoembryonic antigen (CEA)

A

Carcinomas of lung, pancreas, stomach, breast, colon

23
Q

CA 125

A

Epithelial tumors of the ovary

24
Q

CA 19-9

A

Pancreatic adenocarcinoma

25
Q

Chromogranin A

A

Neuroendocrine tumorm (carcinoid, pheochromocytoma)

26
Q

Placental alkaline phosphatase (PLAP)

A

Seminoma

USMLE STEP 1 (24 decks)

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