Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Bio 331 Final Exam > Cell Interactions > Flashcards

Cell Interactions Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

What are extracellular interactions

A

Cells interacting with their extracellular environment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the epidermis

What is the dermis

A

An area of of clocsley packed epithelial tissue cells

A type of connective tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What do the fibroblasts of the dermis do

A

These fibroblasts have receptors that mediate interactions and transmit messages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are cell interactions needed for

A

Intercellular communication (like signal transduction)

Survival

Tissue strength

Organ/immune system function

Embryonic development

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 4 families of integral membrane protiens that mediated cel cell adhesion

A

Selectins

Immunoglobulin superfamily

Members of the integrin family

Cadherins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Slide 14 for roles of integral membrane protiens overveid

A

Okay

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are cadherins

A

They a calcium dependent integral membrane protiens

adhere cells together or transmit signals by two coming together from opposite cells

Most important protiens that can mold cells in the embryo into tissues and hold them together in adults

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Where are cadherins found

A

Along cell surfaces

Part of intracellular junctions:

Synapses
In the adherins junctions
In desmosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

If cadherins are gone what is the result

A

Leads to cancer (malignancy)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

In what way do cadherins mediate the cell cell recognition during embryogenesis

A

Initially the embryo is mixed up cells

Each of these mixed up cells have different affinities for each other, this helps form the ecto endo and meso derm

The cadherins allows the separated cells to redistribute and adhere to cells of the same type to more the different germ layers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Explain how the cadherins can help in different species growing human like organs

A

Stem cells from differentiated human cells were added to a developing pig embryo

The humans cells actually integrated into the tissues of the developing pig because the cadherins of the two species cells were similar

This supported the development of the embryo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the immunoglobulin super family (igSF)

A

They do calcium Independent adhesion (no calcium involved)

They have ig (immunoglobulin) domains that connect to the integrin family or another IGSF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are ICAMS and VCAMS

A

Intercellular adhesion molecules (ICAMS)
Vascular (VCAMS)

Many IGSF protiens are ICAMS

Integrins are integral membrane protiens on the cell that are receptors for ICAMS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are selectins

A

There is E P OR L selectins

They all bind calcium dependently

They are a family of glycoprotiens that bind to specific oligosaccharides on another cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the structure of a selectin

A

They have a small cyctoplasmic segment

A membrane spanning domain

A large extracellular portion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is a lectin

A

A compund that binds to specific carbohydrate groups

17
Q

What is e selectin

A

On endothelial cells

18
Q

What is p selectin

A

On platelets and endothelial cells

19
Q

What is l selectin

A

On leukocytes (white blood cells)

20
Q

How to neutrophils (phagocytic white blood cells) move from the bloodstream into the tissue during inflammation

A

The inflammation activates the endothelial cells which causes their selectins to because more adhesive to neutrophils (upregulated)

These activated selectins bind to the carb residues (psgl-1) of the neutrophil

The platelet activating factor (IL-8) on the endothelial cells activated g protien coupled receptors on the neutrophil

This activates the integrin protiens on the neutrophil which bind to ICAMs on the endothelial cell surface

The cytoskeleton of the neutrophil rearranges and the cell exatravasates (leaves the blood vessel)

21
Q

Neutrophils leave the blood stream via

A

Transendotheilial migration

22
Q

What is metastasis

A

The spread of cancer

23
Q

What do cancer cells do

A

They don’t have normal growth control mechanisms so they proliferate in unregulated manner

24
Q

What protien is most important in reducing cancer

A

E cadherins

25
Q

What is a primary tumor

What is secondary

A

The first appearance of a tumour

The new tumours formed after the primary one spreads

Bio 331 Final Exam (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions