Cell Injury - Reversible and Irreversible

Question 1

Acute cell swelling is also known as?

Answer 1

Hydropic degeneration, hydropic change, cytotoxic edema (CNS), ballooning degeneration (epidermis)

Question 2

Necrosis in the CNS is called?

Answer 2

Malasia

Question 3

What cell types are highly vulnerable to hypoxia and cell swelling?

Answer 3

1. Cardiomyocytes
2. Proximal renal tubule epithelium
3. Hepatocytes
4. Endothelium
5. CNS neurons

Question 4

Acute cell swelling is

Answer 4

early, sub-lethal manifestation of cell damage characterized by an increase in cell size and volume due to water overload
**most common cell injury

Question 5

What are 2 common etiologies of acute cell swelling?

Answer 5

1. Hypoxia

2. Toxic agent

Question 6

Ballooning degeneration results in the formation of what?

Answer 6

It forms a vesicle or a blister

Question 7

Lipidosis (Hepatic lipidosis) and where is this seen?

Answer 7

Accumulation of TG and other lipid metabolites within parenchymal cells - heart muscle, skeletal muscle, kidney, liver

Question 8

Causes of fatty change (3)

Answer 8

hypoxia, toxicity, metabolic disorders

Question 9

Other names for hepatic lipidosis are?

Answer 9

fatty liver, fatty change and hepatic steatosis

Question 10

T/F Hepatic lipidosis is mainly physiologic.

Answer 10

True

Question 11

slide 34

Answer 11

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