Cell Injury & Cell Death

Question 1

Alteration in cell structure or function due to stress or pathologic stimuli

Answer 1

Cellular Injury

Question 2

Cell injury due to loss of oxygen level

Answer 2

Hypoxia

Question 3

Cell injury due to accidents in any form of physically-induced type of injury

Answer 3

Physical Agents

Question 4

Cell injury cthat can be harmful to the body

Answer 4

Chemical Agents and Drugs

Question 5

Cell injury due to bacteria, parasites, and viruses

Answer 5

Infectious agents

Question 6

Cell injury due to allergies

Answer 6

Immunologic Reaction

Question 7

Cell injury due to no homeostasis in the tissues

Answer 7

Nutritional Imbalances

Question 8

Earliest manifestation of cell injury

Answer 8

Generalizing swelling of cell

Question 9

Due to increase in the number of free radicals

Answer 9

Blebbing of plasma membrane

Question 10

Protruded portion of the plasma membrane

Answer 10

Blebs

Question 11

Protruded portion of the plasma membrane

Answer 11

Blebs

Question 12

Cell size in apoptosis

Answer 12

Reduced

Question 13

Cell size in Necrosis

Answer 13

Enlarged (swelling)

Question 14

Plasma membrane in apoptosis

Answer 14

Intact

Question 15

Plamsa membrane in necrosis

Answer 15

Disrupted

Question 16

Cellular contents in apoptosis

Answer 16

Intact

Question 17

Cellular contents in necrosis

Answer 17

Enzymatic digestion (leaking)

Question 18

Which cell death has adjacent inflammation

Answer 18

Necrosis (frequent)

Question 19

Nucleus in apoptosis

Answer 19

Fragmentation into nucleosome-size fragments

Question 20

Nucleus in Necrosis

Answer 20

Pyknosis -> Karyorrhexis -> Karyolysis

Question 21

Which cell death is Physiologic

Answer 21

Apoptosis

Question 22

Which cell death is Pathologic

Answer 22

Necrosis

Question 23

Are cysteine proteases that can cleave the aspartic residue

Answer 23

Caspases

Question 24

Physiologic vs Pathologic

Eliminates cells that are no longer needed

Answer 24

Physiologic

Question 25

Physiologic vs Pathologic Eliminates cells that are injured beyond repaire

Answer 25

Pathologic

Question 26

Types of necrosis according to location

Answer 26

Focal Massive

Question 27

Location of necrosis only happened on a certain area of the body

Answer 27

Focal

Question 28

Location of necrosis is widespread

Answer 28

Massive

Question 29

Type of necrosis according to morphology

Answer 29

Coagulative Liquefactive Gangrenous Caseous Fat Fibrinoid

Question 30

Necrosis where tissue is firm and eosinophilic

Answer 30

Coagulative

Question 31

Main cause of coagulative necrosis

Answer 31

Ischemia

Question 32

Lack/Low oxygen supply on Organ/Tissue

Answer 32

Ischemia

Question 33

Necrosis where tissue becomes liquid viscous mass due to digestion of dead cells

Answer 33

Liquefactive

Question 34

Liquefactive Necrosis occurs during

Answer 34

Microbial infection

Question 35

Liquefactive Necrosis affects

Answer 35

CNS

Question 36

Necrosis that is considered a "massive tissue death"

Answer 36

Gangrenous

Question 37

Combination of Coagulation and Liquefaction

Answer 37

Gangrenous

Question 38

2 types of Gangrenous necrosis

Answer 38

Dry Wet

Question 39

Gangrene considered as sterile type with sharp demarcation line

Answer 39

Dry

Question 40

Determines up to what extent the gangrene is

Answer 40

Demarcation Line

Question 41

Gangrene where odor is more foul due to increase bacterial actions, and has rotting appearance

Answer 41

Wet

Question 42

Cheese-like necrosis, friable white appearance that is seen in tuberculosis and granuloma

Answer 42

Caseous

Question 43

Necrosis where lipase splits the neutral fats into fatty acids and glycerol

Answer 43

Fat

Question 44

Fatty Acids + Calcium causes

Answer 44

Fat Saponification (chalky-white appearance)

Question 45

Necrosis seen in immune reactions when antigen-antibody complexes are deposited in walls of arteries

Answer 45

Fibrinoid

Question 46

Immune complex + fibrin = ?

Answer 46

Fibrinoid

Question 47

Cell injury passed down through pregnancy

Answer 47

Genetic Abnormalities