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MOLECULAR PATHOLOGY CANTONI > CELL INJURY AND DEATH > Flashcards

CELL INJURY AND DEATH Flashcards

1
Q

Targets of cell injury

A

Membranes, mitochondria, endoplasmic reticulum, DNA, proteins + DNA damage and protein misfolding

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2
Q

Type of cell injury

A

Ischemia-hypoxia
Physical agents
Chemical agents
Infectious agents
Immunity
Nutritional imbalance
Mutations

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3
Q

What does it happen when we have a cell injury?

A

ATP depletion
Mitochondrial damage
Increase of intracellular Ca
Production of radicals and ROS

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4
Q

Morphological changes during apoptosis

A

Cell shrinking
Chromatin condensation
Apoptotic bodies
Phagocytosis

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5
Q

Two types of necrosis

A

Coagulative necrosis: protein denaturation
Colliquative necrosis: enzymatic digestion

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6
Q

Differences between necrosis and apoptosis

A

Inflammation
Morphological changes
Programmed vs accidental

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MOLECULAR PATHOLOGY CANTONI (9 decks)

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