Cell Injury and Adaptation Cases Flashcards
Normal cells handle physiologic demands and maintain metabolic functions within narrow ranges
Adaptation
T/F: Ductal metaplasia is a physiologic process in the breast
False
Debited disordered growth and maturation of epithelial cells that may progress into cancer
Epithelial dysplasia
Common manifestation of sublethal cell injury, or uncommonly, of inborn errors in fat metabolism
Intracellular lipid deposition
T/F: Breast stroma has a role in lactation and does not increase with pathologic process
False
Poor or subnormal development of tissues
Hypoplasia
Manifested in inherited disorders of the skeletal muscles that lead to muscle fiber destruction, weakness and wasting
Dystrophy
Change that happens during inflammation from the reflux of the gastric acid
Columnar metaplasia
Intestinal infarction
Coagulative necrosis
TB infection
Caseous necrosis
Breakdown product of hemoglobin which imparts a yellow appearance to tissues
Bilirubin
Wear and tear pigment that increases with aging
Lipofuscin
T/F: When glycogen is increased in the heart, the heart size increases
True
Membrane protein associated with cell adhesion molecules
B-catenin
Cell adhesion molecules involved in leukocyte recirculation
Selectin and cadherin
A genetic disorder wherein the sphingolipid glucocerebroside accumulates in cells and organs since the body has a problem metabolizing it
Gaucher’s disease
An autosomal recessive disorder, a form of sphingolipid called gangliosides accumulate in the cell membrane leading to the premature cell death of neurons
Tay-Sachs disease
Dysplasia of the squamous cells of the cervix usually due to HPV infection
High grade squamous intraepithelial lesion
Premature aging in children
Hutchinson-gilford progeria
Progeria is disease caused by mutations in the?
Human lamin A gene (LMNA)
Lack of corticotrophin resulting in atrophy of the adrenal cortex, which leads to adrenal insufficiency
Sheehan syndrome
Chronically reduced oxygen supply leads to?
Cell atrophy
Myositis ossificans represents a form of?
Osseous metaplasia
Single necrotic cells on which several layers of mineral get deposited progressively to create lamellated shape
Psammoma bodies
Special type of wet gangrene caused by infection with a gas forming anaerobic clostridia
Gas gangrene
