Cell Injury and Adaptation Cases

Question 1

Normal cells handle physiologic demands and maintain metabolic functions within narrow ranges

Answer 1

Adaptation

Question 2

T/F: Ductal metaplasia is a physiologic process in the breast

Answer 2

False

Question 3

Debited disordered growth and maturation of epithelial cells that may progress into cancer

Answer 3

Epithelial dysplasia

Question 4

Common manifestation of sublethal cell injury, or uncommonly, of inborn errors in fat metabolism

Answer 4

Intracellular lipid deposition

Question 5

T/F: Breast stroma has a role in lactation and does not increase with pathologic process

Answer 5

False

Question 6

Poor or subnormal development of tissues

Answer 6

Hypoplasia

Question 7

Manifested in inherited disorders of the skeletal muscles that lead to muscle fiber destruction, weakness and wasting

Answer 7

Dystrophy

Question 8

Change that happens during inflammation from the reflux of the gastric acid

Answer 8

Columnar metaplasia

Question 9

Intestinal infarction

Answer 9

Coagulative necrosis

Question 10

TB infection

Answer 10

Caseous necrosis

Question 11

Breakdown product of hemoglobin which imparts a yellow appearance to tissues

Answer 11

Bilirubin

Question 12

Wear and tear pigment that increases with aging

Answer 12

Lipofuscin

Question 13

T/F: When glycogen is increased in the heart, the heart size increases

Answer 13

True

Question 14

Membrane protein associated with cell adhesion molecules

Answer 14

B-catenin

Question 15

Cell adhesion molecules involved in leukocyte recirculation

Answer 15

Selectin and cadherin

Question 16

A genetic disorder wherein the sphingolipid glucocerebroside accumulates in cells and organs since the body has a problem metabolizing it

Answer 16

Gaucher’s disease

Question 17

An autosomal recessive disorder, a form of sphingolipid called gangliosides accumulate in the cell membrane leading to the premature cell death of neurons

Answer 17

Tay-Sachs disease

Question 18

Dysplasia of the squamous cells of the cervix usually due to HPV infection

Answer 18

High grade squamous intraepithelial lesion

Question 19

Premature aging in children

Answer 19

Hutchinson-gilford progeria

Question 20

Progeria is disease caused by mutations in the?

Answer 20

Human lamin A gene (LMNA)

Question 21

Lack of corticotrophin resulting in atrophy of the adrenal cortex, which leads to adrenal insufficiency

Answer 21

Sheehan syndrome

Question 22

Chronically reduced oxygen supply leads to?

Answer 22

Cell atrophy

Question 23

Myositis ossificans represents a form of?

Answer 23

Osseous metaplasia

Question 24

Single necrotic cells on which several layers of mineral get deposited progressively to create lamellated shape

Answer 24

Psammoma bodies

Question 25

Special type of wet gangrene caused by infection with a gas forming anaerobic clostridia

Answer 25

Gas gangrene