Cell Divison, Cell Diversity And Cell Differentiation Flashcards
What is interphase?
Phase of cell cycle where the cell is not dividing; it is subdivided into growth and synthesis phases
What is mitosis.
Type of nuclear division that produces daughter cells genetically identical to each other and to the parent cell
What is cytokinesis?
Cytoplasmic division following nuclear division, resulting in two new daughter cells
What are the two main checkpoints?
G1/s checkpoint also called restriction point
G2/M checkpoint
What are the purpose of checkpoints?
Prevent uncontrolled division that would lead to tumours
Detect and repair damage to DNA
M phase
A checkpoint chemical triggers condensation of chromatin
Halfway through the cycle, metaphase checkpoint ensures cell is ready to complete mitosis
Events during M phase
Cell growth stops
Nuclear division consisting of stages: prophase, metaphase, anaphase and telophase
Cytokinesis
G0 phase
Resting phase triggered during early g1 at the restriction point, by a checkpoint chemical
Some cells don’t have this
Events during g0 phase
Cells undergo apoptosis, differentiation or senescence
Some types of cells remain in this phase for a very long time
G1 phase (also called growth phase)
G1 checkpoint control mechanism ensures that the cell is ready to enter the s phase and begin DNA synthesis
Events in G1
Cells grow and increase in size Transcription Organelles duplicate Biosynthesis P53 gene helps control this phase
S phase of interphase
Because chromosomes are unwound and DNA is diffused, every molecule of DNA is replicated
Housekeeping genes which are active in all cells are duplicated first
Normally inactive genes are duplicated last
Events in s phase
Once entering this phase, cell is commited to completing cell cycle
DNA replicates
When all chromosomes are duplicated, each one consists of a pair of identical sister chromatids
Phase is rapid and exposed DNA are more susceptible to mutagenic agents. Reduces the chance of spontaneous mutation
G2 phase of interphase
Chemicals ensure the cell is ready for mitosis by stimulating proteins that will be involved in making chromosomes condense and in formation of spindles
G2 events
Cells grow
What are chromatids?
Replicates of chromosomes
What is cytokinesis?
Division of the cytoplasm of a cell following mitosis
What is mitosis?
Type of nuclear division that maintains the chromosome number; each new daughter cell contains the same genetic information as the parent cell. Genetically identical
What is asexual reproduction and where does it occur?
Single celled protoctists such as amoeba divide by mitosis
Some plants produce new plantlets on the end of stolons
Fungi use mitosis
Some female sharks without male produces offspring that is genetically identical
Aphids may produce eggs that do not need fertilising
How do multicellular organisms grow?
All multicellular organisms grow by producing cells that are genetically identical to each other and to the parent cell from which they arose by mitosis
How do tissues repair?
Wounds heal when growth factors, secreted by platelets and macrophages and damages cells of the blood vessel walls, stimulate the proliferation of endothelial and smooth muscle cells to repair damaged blood vessels
Events during prophase?
Chromosomes shorten and thicken as DNA is supercoiled
Nuclear envelope breaks down
Centriole in animal cell divides and two new daughter centrioles move to opposite poles
Cytoskeleton protein threads form spindles between centrioles
(In plants tubulin threads form from cytoplasm)
Events during metaphase
Pairs of chromosomes attach to the spindle threads at the equator region
Attach at their centromeres
Events during anaphase
Centromere of each pair of chromatids splits
Motor proteins, walk along tubulin threads, pull each sister chromatid of a pair to opposite poles
Chromosomes assume a v shape
Events during telophase
Separated chromosomes tech poles
Nuclear envelope forms around each set
Cell now contains two nuclei genetically identical to parent cell they arose from
What’s happens in animals and plants during cytokinesis?
Animals- plasma membrane folds inwards and nips in the cytoplasm
Plant- an end plate forms where the equator of the spindle was, and new plasma membrane and cellulose cell wall materials are laid down either side along this end plate
What’s a haploid?
Having only one set of chromosomes presented by the symbol ‘n’
What are homologous chromosomes?
Matching chromosomes, containing the same genes at the same places. They may contain different alleles for some genes
What is meiosis?
Type of nuclear division that results in the formation of cells containing half the number of chromosomes of the parent cell
Why does sexual reproduction increase genetic variation?
Involved the combining of genetic material from 2 unrelated individuals of the same species, by the process of fertilisation.
Why is genetic variation important?
Increases its chances of survival when the environment changes
Some individuals have characteristics that enable them to be better adapted to the change
What are most body cells?
Diploid
What must be produced for sexual reproduction to occur?
Haploid gametes
What are matching pairs of chromosomes called?
Homologous pair
How many divisions are there in meiosis?
2
Prophase 1
Crossing over.
Chromosomes compromise 2 chromatids
Centrioles at opposite ends of cell
Nuclear envelope disintegrates
Events during prophase 1
Chromatin condenses and each chromosome supercoils
Envelope breaks down
Spindle threads of tubulin protein form from centrioles
Chromosomes come together in homologous pairs
Each member of pair consists of 2 chromatids
Crossing over occurs between non sister chromatids. May swap sections so alleles are shuffled
Metaphase 1
Spindles attach to centromere at equator