Cell death Flashcards
State of irreversible injury
Cell death
2 types of cell death
Necrosis and Apoptosis
Death by injury
Necrosis & autolysis
Death by suicide
Apoptosis
______is disintegration of the cell by its own hydrolytic enzymes liberated from lysosomes
Autolysis
It occurs in the living body in places surrounded by inflammatory
reaction or it may occur as post-mortem change in which there is
complete absence of surrounding inflammatory response.
Autolysis
Focal death along with protein
denaturation & degradation of tissue by hydrolytic enzymes liberated by cells.
Necrosis
Caused by various agents such as hypoxia,
chemical and physical agents, microbial agents and immunological injury
Necrosis
Programmed cell death
Apoptosis
Cells are destined to die activate intracellular enzymes that degrade the cells’ own nuclear DNA and nuclear and cytoplasmic proteins in which type of cell death?
Apoptosis
It means “falling off” or “dropping off” in Greek
Apoptosis
Why is apoptosis important?
It eliminates unwanted and harmful cells
Chromatin condensation, Cell shrinkage & membrane blebbing, Preservation of organelles and cell membranes, Rapid engulfment by, Macrophages preventing inflammation.
Apoptosis
Nuclear swelling Cell swelling Disruption of organelles
Necrosis
