Cell Cycle Proteins

Question 1

Activation of MYC leads to what?

Answer 1

Increase cyclin D production

Question 2

Activation of Ras leads to what cascade?

Answer 2

MAPK> MYC> cyclin D

Question 3

Cyclin D

Answer 3

G1 associated, phosphorylates SOME Rb>SOME E2F released> cyclin E produced

Question 4

CDK4/6

Answer 4

complexes with cylcin D which then enters the G1 phase

Question 5

Cyclin E

Answer 5

HYPERphosphorylates Rb> ALL E2F released> continuation to S phase past Restriction point

Question 6

CDK2

Answer 6

complexes with cyclin E, then cyclin A in G1 and S phase

Question 7

Rb

Answer 7

protein that allows activation of E2F

Question 8

E2F

Answer 8

when free, activates transcription of S phase genes

Question 9

P16

Answer 9

Protein under INK4, inhibits CDK4/6 ONLY

Question 10

When does P16 activate?

Answer 10

during times of environmental stress.

Question 11

At what phase can p16 halt the cell cycle?

Answer 11

G1 ONLY

Question 12

p21

Answer 12

CDK inhibitor, under WAF1/CIP1 group

Question 13

Which CDK’s can p21 inhibit?

Answer 13

ALL CDK’s except CDK4/6

Question 14

When is p21 induced?

Answer 14

after DNA damage

Question 15

At what phase can p21 halt the cell cycle?

Answer 15

at ANY phase

Question 16

p53 binds to what promoter region?

Answer 16

promoter region of p21

Question 17

after p53 binds to the promoter region of p21 what happens?

Answer 17

activates p21…more of it is made

Question 18

When is p53 produced?

Answer 18

when the cell detects DNA damage

Question 19

What is another name for p53???

Answer 19

GUARDIAN OF THE GENOME

Question 20

Is p53 is a tumor suppressor?

Answer 20

YESSSUM!

Question 21

What happens if there is a mutation in Rb, p16, p21, or p53???

Answer 21

cell will go through cycle even though is bad