Cell Cycle - Pfeffer Flashcards

1
Q

What is the typical cell cycle?

A

G1->S->G2->M then starts with G1 again.

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2
Q

What is the most variable part of the cell cycle?

A

G1 phase anywhere from 6-12 hours.

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3
Q

What are examples of permanent cells?

A

neurons and fat cells.

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4
Q

What type of cells are liver cells? (permanent, stable, or labile)?

A

stable

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5
Q

What happens if cell is not ready to move on during the G1 phase?

A

rate of cell proliferation of most mammalian cells is regulated through G1 transit. If not ready, cell will go into a ‘sleep’ phase called G0 with a stepdown of RNA and protein synthesis. If under severe stress, will undergo apoptosis.

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6
Q

What is the S phase?

A

initiation of DNA synthesis with euchromatin first and then heterochromatin. Synthesis of key proteins like histones and enzymes for DNA replication.

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7
Q

What happens during the G2 phase?

A

synthesis of proteins required for mitosis

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8
Q

What happens during the M phase?

A

Almost no RNA synthesis. Mitosis occurs.

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9
Q

What is the Hayflick number?

A

How many times cells can divide. Inversely related to age capacity.

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10
Q

What is progeria?

A

disease that only allows cells to divide a few times. Cause premature aging.

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11
Q

What is senescence?

A

state when cells can no longer divide. They begin to slow down in their production of proteins and RNA. They eventually die and the progeny is ended.

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12
Q

What is MPF?

A

maturation promoting factor. Have high levels when cells undergo mitosis.

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13
Q

What is the Wee1?

A

??

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14
Q

What is p27 inhibitory protein?

A

??

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15
Q

What is APC?

A

targets cohesins for degradation as well as CDK complexes.

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16
Q

Look at checkpoint summary slide at end of lecture.

A

???