Cell Cycle Overview Flashcards
Interphase
Interphase is the first and longest stage of the cell cycle, involving cellular growth and duplication of chromosomes. Composed of three phases: G1, S, and G2. During interphase, the cell synthesizes necessary DNA, proteins, and organelles for growth and replication.
Mitosis
Mitosis is the second stage of the cell cycle involving the complete separation of sister chromatids and nuclei. Consists of four sub-stages: prophase, metaphase, anaphase, and telophase.
Prophase
Prophase involves the condensation of chromatin into distinct chromosomes, migration of centrioles, breakdown of the nuclear membrane, and disappearance of the nucleolus.
Metaphase
Metaphase sees spindle fibers fully form and attach to the centromere of each chromosome, guiding them to the cell’s equator.
Anaphase
Anaphase involves the splitting of the centromere and pulling of sister chromatids to opposite ends of the cell.
Telophase
Telophase is similar to prophase in reverse, with the formation of two genetically identical nuclei.
Cytokinesis
Cytokinesis is the division of the cytoplasm and formation of two daughter cells.
Animalia cell split
In animals, cytokinesis occurs with the development of a cleavage furrow that pinches the plasma membrane into two cells.
Plant cell split
In plants, a cell plate forms at the equator before separating into two cells due to the presence of a cell wall.
Cell Cycle Checkpoints
The cell cycle has three checkpoints at the end of the G1 and G2 phases, and during metaphase.
G1
G1 checkpoint verifies cell size, protein synthesis for DNA replication, DNA damage, and nutrient availability.
M
Metaphase checkpoint checks the formation of spindle fibers before proceeding to anaphase.
G2
G2 checkpoint ensures proper DNA replication and resource availability for mitosis.
Chromosome Structure
Chromosomes are structures composed of DNA tightly wrapped around histone proteins, carrying the genetic information of a cell.
Sister chromatids
Sister chromatids are the identical halves of a replicated chromosome.