Cell cycle

Question 1

Cell cycle phases are regulated by

Answer 1

Cyclin
Cyclin dependent kinases
tumor suppressors

Question 2

What is the shortest phase of the cell cycle ?

Answer 2

M Cycle

Question 3

Phases of mitosis

5 phases

Answer 3

Prophase
Prometaphase
Metaphase
Anaphase
Telophase

Question 4

Which phase of cell cycle is of variable duration

Answer 4

G1 phase

Question 5

Cyclin dependent kinases are expressed _____ (constitutively/non constitutively)

Answer 5

Constitutively

Question 6

What kind of protein is cyclin?

Answer 6

phase specific regulatory proteins

Question 7

What complex should be activated/inactivated for cell cycle to progress

Answer 7

Cyclin-CDK complexes

Question 8

Which phase does p53 inhibit

Answer 8

G1-S progression inhibition

Question 9

Li Fraumeni syndrome

Answer 9

mutation in tumor suppressor gene

results in unrestrained division

Question 10

What factors transition the cell from G1 to S phase

Answer 10

Growth factors like insulin ,PDGF, EPO, EGF

by binding to tyrosine kinase receptor

Question 11

Name the 3 cell types on basis of transition from G0 to G1

Answer 11

Permanent , Stable, Labile

Question 12

Permanent cell type examples

Remains in G0 phase and regen from stem cell

Answer 12

Neurons
Skeletal muscle
Cardiac muscle
RBC

Question 13

Stable cell types examples

enter G1 from G0 when stimulated

Answer 13

Hepatocytes
Lymphocytes
PCT
Periosteal cells

Question 14

Labile cell types examples

never G0 rapid G1

Answer 14

Bone marrow
Gut Epithelium
Skin
Hair
Follicles
Germ Cells

Question 15

Which cell type (basis: division) is most affected by chemotherapy

Answer 15

Labile cell type

Question 16

Role of Nissl bodies

Answer 16

synthesize peptide neurotransmitters for secretion

Question 17

What proteins do free ribosome synthesize

Answer 17

Cytosolic
peroxisomal
mitochondrial

Question 18

Where in cell does N linked glycosylation occur

Answer 18

Endoplasmic reticulum

Question 19

What is the function of smooth endoplasmic reticulum

Answer 19

Steroid synthesis
Detoxification of drugs and poisons

Question 20

Where does the last step of glycogenolysis and gluconeogenesis occur?

Answer 20

Glucose 6 phosphate to glucose

Question 21

Which cells in the body are rich in SER

Answer 21

Hepatocytes
Cells of Adrenal Cortex
Gonads

Question 22

The eukaryotic cell grows and makes a copy of its DNA during _______ of the cell cycle.

Answer 22

Interphase

Question 23

At the end of the ___phase of the cell cycle, centrioles begin to replicate.

Answer 23

G1

Question 24

During the (2)_____ of interphase, the cell grows and copies its organelles.

Answer 24

G1 and G2 phases

Question 25

Contractile cytokinesis occurs in animal cells due to the action of the _______ contracting inward and pinching the cell in two.

Answer 25

contractile ring

Question 26

The _______promoting factor is a protein complex that is required to allow the cell to move from the G2 phase to the M phase.

Answer 26

M-phase