Cell-cell Adhesion/ECM Flashcards
Cell-cell adhesion is the process in which cells ________________.
The membrane proteins involved in the process are called __________________.
Cell-cell adhesion is the process in which cells ATTACH AND INTERACT.
The membrane proteins involved in the process are called CELL-ADHESION MOLECULES (CAMS).
What are the four major CAM families ?
- Cadherins
- Integrins
- Immunoglobulins (Ig)
- Lectins (selectins)
What are the types of binding that can occur with CAMS?
- Homotypic adhesion = cell bind to the same kind of CAM
- Heterotypic adhesion = cell of different types bind to different CAMS
What are the two types of interactions that can occur in CAMS?
- Cis. Interactions = takes place between molecules on same cell surface
- Trans interactions = takes place between molecules on different surfaces “Velcro-like”
The Extracellular matrix is a mesh structure made of ____________ that surrounds a _________.
It serves as ____________ within a tissue
The main component of the ECM is __________________.
The Extracellular matrix is a mesh structure made of WATER AND PROTEIN that surrounds a CELL.
It serves as SUPPORT within a tissue.
The main component of the ECM is GLYCOPROTEIN COLLAGEN.
Name the 5 components of the ECM
- Collagen
- Integrins
- Fibronectins
- Proteoglycans
- Elastin
Match these up:
- Collagen =
- Proteoglycans =
- Fibronectin =
- Integrin =
- Elastin =
A. gives flexibility to tissues, abundant in ECM
B. gives mechanical support, resistance to stretching forces.
C. attaches to integrins in the plasma membrane
D. involved in cell attatchment to the ECM, cell communication
E. a mesh where collagen fibres are embedded
- Collagen = gives mechanical support, resistance to stretching forces.
- Proteoglycans = a mesh where collagen fibres are embedded
- Fibronectin = attaches to integrins in the plasma membrane
- Integrin = involved in cell attatchment to the ECM, cell communication
- Elastin = gives flexibility to tissues, abundant in ECM
1B , 2E, 3C, 4D, 5A
What are some functions of the ECM?
- Define tissues boundaries
- Determines biomechanical properties such as stiffness or elasticity
- Controls cellular polarity
- Provides signalling information for cell
The ECM is formed of which two components of the cell?
The basil lamina and connective tissue
Integrins are _________, they have alpha and beta parts.
They are __________ which bind to _____________ proteins.
Integrins have _________ into the cell to influence _________ for example cell survival, gene transcription.
Integrins are HETERODIMERIC, they have alpha and beta parts.
They are ADHESION RECEPTORS which bind to MULTI-ADHESIVE MATRIX proteins.
Integrins have SIGNALLING PATHWAYS into the cell to influence CELLULAR RESPONSE for example cell survival, gene transcription.
What integral membrane proteins in INTEGRINS are linked to the intermediate filaments?
PLAKINS
What colour does the NUCLEI stain under hematoxylin eosin staining?
Purple
What colour does the CYTOPLASM stain under hematoxylin eosin staining?
PINK
