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Cell Bio I > Cell Biology IV > Flashcards

Cell Biology IV Flashcards

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1
Q

What protein is involved in constructing and shaping of the sER?

A

Atlastin

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2
Q

What class of protein is atlastin?

A

GTPase

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3
Q

What happens to the ER and Golgi in response to an abundance of atlastin?

A

1) Increased ER membrane fusion

2) Absence of Golgi

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4
Q

What happens to the ER as a result of atlastin deficiency?

A

ER fragmentation

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5
Q

ER fragmentation occurs in response to a deficiency in what protein?

A

Atlastin

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6
Q

Hereditary spastic paraplegia is caused from a deficiency in what protein?

A

Atlastin

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7
Q

What condition arises due to atlastin deficiency?

A

Hereditary spastic paraplegia

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8
Q

What are symptoms of hereditary spastic paraplegia?

A

1) Leg stiffness

2) Gait disturbances (stumbling, tripping)

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9
Q

Proteasomes make up what percentage of cellular proteins?

A

1%

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10
Q

Are proteases ATP-dependent?

A

Yes

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11
Q

Where are proteasomes located in the cell?

A

Cytoplasm and nucleus

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12
Q

Proteasomes are involved in proteolysis of what types of proteins?

A

1) Regulating proteins (e.g. cell cycle, txn, apoptosis)
2) Malformed, denatured, damaged proteins
3) Antigenic proteins (cleaved and presented to T cells)

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13
Q

Are proteasomes ubiquitin-dependent, -independent, or both?

A

Can be either (both)

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14
Q

Proteasomes are inhibited by what type of molecule?

A

Abnormal prion proteins

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15
Q

What effect to abnormal prion proteins have on proteasomes?

A

Inhibition

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16
Q

Defective proteolysis by proteasomes is causative in what diseases?

A

Parkinson’s disease, cystic fibrosis

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17
Q

What is the function of bortezomib in cancer cell therapy?

A

Bortezomib partially inhibits proteasomes, thus decreasing the degradation of pro-apoptotic factors

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18
Q

In polarized cells, where is the Golgi located?

A

Between the nucleus and apical cytoplasm

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19
Q

When is a negative Golgi image seen?

A

In active protein-secreting cells

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20
Q

What is a negative Golgi image?

A

A pale-staining area of cytoplasm seen in H&E staining (neither acidophilic nor basophilic)

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21
Q

In which direction is the cis-Golgi oriented in the cell?

A

Presents toward the transitional ER where transport vesicles are forming

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22
Q

What is formed from the trans-Golgi?

A

1) Secretory granules (vesicles)
2) Lysosomes
3) Membrane protein-transporting vesicles

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23
Q

Where are lysosomal enzymes tagged with mannose-6-phosphate?

A

Golgi

24
Q

Where is the mutation in Wilson’s disease?

A

Mutation in a protein pump for copper in the trans-Golgi network of liver cells

25
Q

What is the result of the mutated protein transporter in Wilson’s disease?

A

Impaired biliary excretion of copper

26
Q

What is the role of dysferlin?

A

Repair of microperforations in skeletal muscle plasma membranes

27
Q

Repair of microperforations in skeletal muscle plasma membranes is accomplished by what molecule?

A

Dysferlin

28
Q

The patching mechanism of dysferlin is dependent upon what mineral?

A

Calcium

29
Q

Mutations of the dysferlin gene lead to what three types of muscular dystrophy?

A

1) Miyoshi myopathy
2) Limb-girdle muscular dystrophy type 2b
3) Distal myopathy tibialis anterior muscle onset

30
Q

How does a mutation in proinsulin lead to proinsulinemia?

A

1) Mutated proinsulin is missorted into the unregulated (constitutive) secretory pathway
2) Prohormone converting enzymes are properly sorted in the regulated pathway
3) Consequently, there is an absence of prohormone converting enzyme activity in the unregulated pathway

31
Q

What are the four types of endosomal compartments?

A

1) Early endosomes
2) Recycling endosomes
3) Multivesicular bodies
4) Late endosomes

32
Q

Where are early endosomes and recycling endosomes located in the cell?

A

Periphery

33
Q

Which endosomal compartments are located at the periphery of the cell?

A

Early endosomes, recycling endosomes

34
Q

What is the pH of early endosomes and recycling endosomes?

A

6.2 - 6.5

35
Q

Which endosomal compartments have a pH of 6.2 - 6.5?

A

Early endosomes, recycling endosomes

36
Q

Which endosomal compartment is responsible for glucose transport in response to insulin?

A

Recyling endosome

37
Q

What is the pH inside multivesicular bodies?

A

5.0 - 6.2

38
Q

Which endosomal compartment has a pH of 5.0 - 6.2?

A

Multivesicular bodies

39
Q

What do multivesicular bodies eventually fuse with?

A

Late endosomes

40
Q

Do multivesicular bodies have a secretory role?

A

Yes

41
Q

Where are late endosomes located in the cell?

A

Near Golgi and nucleus

42
Q

Late endosomes either fuse or mature into _______

A

Lysosomes

43
Q

What is another term for late endosomes?

A

Prelysosomes

44
Q

What is the pH of late endosomes?

A

5.0

45
Q

Which endosomal compartment has a pH around 5.0?

A

Late endosome

46
Q

What are the four fates of receptor-ligand complexes?

A

1) Receptor is recycled, ligand is degraded or released for use (e.g. LDLr)
2) Receptor and ligand are recycled (e.g. TfR)
3) Receptor and ligand are degraded (e.g. FGFR3 - reverse occurs, leading to achondroplasia)
4) Receptor and ligand are transported across cell and secreted (transcytosis, e.g. antibodies in glandular cells)

47
Q

What do lysosomes transport?

A

Lysosomal hydrolases and other ions and molecules

48
Q

In which cell type are lysosomes most abundant?

A

Phagocytic cells (macrophages, neutrophils)

49
Q

What is an autophagolysosome (secondary lysosome)?

A

Primary lysosome + autophagosome

50
Q

Primary lysosome + autophagosome = ?

A

Autophagolysosome (secondary lysosome)

51
Q

What is a heterophagolysosome?

A

Primary lysosome + heterophagosome

52
Q

Primary lysosome + heterophagosome = ?

A

Heterophagolysosome

53
Q

What are residual bodies?

A

Lysosomes that contain undigested waste

54
Q

Accumulated waste in residual bodies eventually forms what inclusion?

A

Lipofuscin

55
Q

Are lysosomes acidophilic or basophilic?

A

Acidophilic

Cell Bio I (11 decks)

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