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Spring Sophomore Year > Cell Bio Exam 3 Clicker Questions > Flashcards

Cell Bio Exam 3 Clicker Questions Flashcards

1
Q

The assembly of actin monomers into and
out of filaments is influenced most
immediately by

A

Whether the actin
monomers are ATP or
ADP bound

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2
Q

Which of the following proteins directly act as actin
filament nucleators in cells?

A

ARP 2/3 complex in
lamellipodia

Formins in filopodia

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3
Q

In cells roughly 99% of the actin subunits are
not found free but instead are found in
filaments which are disassembled and quickly
reassembled in different cellular locations.

A

False

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4
Q

How is the troponin protein found in muscle cells
regulated to control muscle contraction and
relaxation?

A

Binding of Ca++ to
the protein

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5
Q

In crawling cells such as the one below,
kinesins moving on actin are important to drive cell motility

A

False

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6
Q

Rho, Rac and Cdc42 are

A

GTPase proteins that
influence actin assembly

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7
Q

In many eukaryotic cells, actin can typically be
found in what main location?

A

Cell cortex

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8
Q

In cells the concentration of actin is very high,
with about half of it being held in monomers
through the action of sequestering proteins

A

True

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9
Q

ARP complex proteins serve to cap and stabilize
the ends of actin filaments in sarcomeres

A

False

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10
Q

Which proteins both bind GTP and regulate
the actin cytoskeleton?

A

Rho and Rac

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11
Q

Which statement(s) below concerning
actin motor proteins is/are True?

A

Myosins move via
ATP hydrolysis

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12
Q

Troponin is a Ca2++ binding protein that regulates muscle contraction

A

True

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13
Q

The distance between the poles of the
mitotic spindle changes during
progression through anaphase

A

True

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14
Q

At metaphase of mitosis when all replicated
chromosomes are at the metaphase plate

A

The chromosomes are under
tension from the poles of the
spindle via kinetochore
microtubules

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15
Q

A specialized protein structure that assembles
at the centromeres of chromosomes and binds
spindle microtubules during cell division

A

kinetochores

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16
Q

The distance between the poles of the
mitotic spindle changes during
progression through anaphase

A

True

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17
Q

Cytokinesis of cells occurs by the interaction
of myosin II proteins with actin to contract
and divide the plasma membrane

A

True

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18
Q

Microtubules are often nucleated by gamma tubulin found at centrosomes.

A

True

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19
Q

What proteins help provide the energy to deform the underlying membrane during the process of vesicle formation?

A

coat proteins

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20
Q

What process occurs during S phase of the cell cycle?

A

replication of chromosomal DNA

21
Q

Gene signatures in Circulating Tumor Cells revealed by High Resolution Heat Map, such as that shown below, show the expression of selected gene panels can be used for diagnosis of primary tumor samples.

A

False

22
Q

PGH tests can be divided into two types: lineage-based and autosomal marker-based tests

A

True

23
Q

Only maternally inherited DNA has been useful for studying genealogical inference

A

False

24
Q

Which type of GO term does nitrogen metabolism represent?

A

Biological Process

25
Q

The term dynamic instability refers to the fact that microtubule plus ends, unless stabilized, will constantly be either growing or rapidly shrinking.

A

True

26
Q

Among the three types of cytoskeletal filaments, the least dynamic are

A

intermediate filaments

27
Q

Plasma membrane proteins found in endocytic vesicles can traffic back, or recycle to the plasma membrane from the endosome, rather than continuing to the lysosome.

A

True

28
Q

Which of the following proteins serves to stabilize the membrane of a transport vesicle during its formation:

A

Coat proteins

29
Q

Which of the following proteins serves to allow transport vesicles to recognize the correct membrane they will dock to:

A

t-SNAREs

30
Q

Gamma tubulin is found at what location in most animal cells?

A

centrosomes

31
Q

How many filamentous structures together comprise the cytoskeleton?

A

3

32
Q

Which parts of the cytoskeleton are nonpolar (do not have a plus and minus end)?

A

Intermediate Filaments

33
Q

Cytoskeletal filaments are polymers of ________________

A

proteins
Explanation: The three cytoskeletal elements are polymers of proteins subunits held together by weak, non-covalent bonds. This characteristic construction leads to rapid assembly and disassembly.

34
Q

Microtubules are formed of the protein ____________

A

tubulin

35
Q

Microtubules of a dividing cell form the mitotic spindle.

A

TRUE
Microtubules of a dividing cell form the mitotic spindle required for chromosome segregation. Microtubules in the nerve and epithelial cells play a role in organelle transport.

36
Q

Microfilaments are composed of the protein ____________

A

actin

37
Q

Secretory proteins are synthesized by ______

A

ribosomes on the ER

38
Q

Posttranslational modification of many eukaryotic proteins begins in the ____________

A

ER

39
Q

Nuclear localization signal is rich in ____________

A

lysine and arginine

40
Q

Nucleotide binding and hydrolysis of GTP is used by cells to regulate the dynamics (assembly/disassembly) of intermediate filaments.

A

False

41
Q

Intermediate filaments can be found where in different types of eukaryotic cells?

A

Cytoplasm
Nucleus

42
Q

Addition of ab heterodimers to growing ends of microtubules depends on:

A

GTP or GDP bound state of tubulins at those ends

43
Q

g-tubulin functions as a microtubule:

A

Nucleating factor at centrosomes

44
Q

Which of the following are microtubule based motors?

A

Kinesins
Dyneins

45
Q

Intermediate filaments are so named because they are intermediate in size between microtubules and actin filaments

A

True

46
Q

Which one of the following best describes the function of intermediate filaments:

A

Provide mechanical strength to cells and organelles

47
Q

Intermediate filaments assemble as:

A

Dimers, then tetramers then multimers forming filaments

48
Q

The dynamics (assembly/disassembly) of intermediate filaments are regulated by their phosphorylation state.

A

True

49
Q

Which type of protein will handle phosphorylation of the nuclear lamins?

A

kinase

Spring Sophomore Year (11 decks)

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