cefazolin Flashcards
what is the classification of cefazolin
First-generation cephalosporin (antibiotic)
what is the trade name for cefazolin
Ancef, Kefzol
what are the patient/family education of cefazolin
because cefazolin and the other cephalosporins are similar to penicllin, follow the same guidelines for providing pt/family education to pt receiving penicillin. take medication exactly as prescribed until the entrie prescription is completed, despite the absence of symptoms. monitor for s/s of allergic response and stop the medication if any occur
what are the ongoing assessment/evaluation of cefazolin
monitor pt for signs of superinfection and notify prescriber immediately to arrange for treatment if superinfection does occur
how many generations of cephalosporins have been introduces
4 generations - each group w/its own spectrum of activity
what are the major differences btwn the generations of cephalosporins
their activity against gram-negative bacteria, their resistence to beta-lactamases, and their ability to distribute into cerebrospinal fluid
what are the pharmacotherapeutics of cefazolin
treat many kinds of infections: skin, bone, heart, blood, respiratory tract, GI tract, sinus, ear, and urinary tract. also used for perioperative prophylaxis in surgeries involving the GI or genitourinary tracts, bones, and skin
how is cefazolin administered
IM
what is the pharmacodynamics of cefazolin
like penicillin G, has no direct effect on the body. cefazolin produces its bactericidal effects by binding with PBP’s, which disrupts bacterial cell wall synthesis. like penicillin, it also activate autolysins, which results in additional damage to the cell wall, allowing the cell to swell and then burst from the osmotic pressure within the cell. like penicillins, it is most effective against cells undergoing active growth and division
c/i and precautions of cefazolin
anyone with a known allergy to cefazolin. caution must be used in patients with renal failure and in pregnant or lactating pts. because of the structural similarities btwn cephalosporins and penicillins, pts who are allergic to one type of drug may experience cross-sensitivity to the other
most common a/e of cefazolin
N/V, diarrhea
most serious a/e of cefazolin
hypersensitivity
maximizing therapeutic effect of cefazolin
when using for gram-negative infections, be sure culture/sensitivity tests are done before administration
minimizing a/e of cefazolin
inject IM preparations into a large muscle mass. be sure IV preparations are administered according to the health care prescriber’s orders, either IV push or IV piggyback
what are the d/i of cefazolin
alcohol
aminoglycosides (gentamicin)
oral anticoagulants
