CD molecules

Question 1

CD79

Answer 1

CD79 or Ig (CD79 alpha & beta/Ig alpha & beta) is associated with Ig B cell receptors (BCR) and contains an ITAM for intracellular signalling on antigen recognition

Question 2

CD3

Answer 2

CD3 is associated with TCR and contains ITAM regions for intracellular signalling upon antigen recognition.
CD3 is composed of epsilon-delta or epsilon-gamma chains in alpha-beta T cells.

Question 3

CD18

Answer 3

Integrin beta 2. binds to CD11.

Important for adhesion to endothelium and ECM. particularly neutrophils.
also binds to antigen presenting cells via ICAM

Question 4

CD69

Answer 4

upregulated when T cells encouner antigen in lymph. this down regulates sphingosine 1 phosphate so time in lymph is increased

Question 5

CD1

Answer 5

associated with MHC.
Present exogenous lipid antigens to NKT cells.
CD1a,b,c expressed on specialised antigen presenting cells
CD1d expressed on a wider variety of cells, including B cells
5 genes

Question 6

CD 207

Answer 6

Langerin, C-type pectin receptor. Expressed by dendritic cells and can transverse HIV through epithelium.

Question 7

CD206

Answer 7

Mannose receptor and PRR. Recognises terminal mannose & N-acetylglucosamine & fucose on pathogens and transports for phagocytosis. Expressed on macrophages and immature DCs. Involved in HIV transport across epithelium.

Question 8

CD209

Answer 8

Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin. (DC-SIGN). C-type pectin receptor. Expressed on macrophages and dendritic cells. Binds to high-mannose type N-glycans and activated phagocytosis. Mediates dc rolling and interaction with endothelium and CD4.