CD Markers and ILs- Flashcards
CD19
B cells
CD14
Monocytes
CD3
T cells
CD4
Helper T cells
CD8
Killer T cells
CD4+CD25+FoxP3
T regulatory cells
CD56
NK cells
CD21 (CR2)
B cells
CD28
T cells
CD154 (CD40L)
T cells
CD80/86 (B7.1/B7.2)
Antigen Presenting Cell
CD40
B cells, some macrophages
IL1
Signs of inflammation
Increased vascular permeability/adhesiveness and diameter
Activates JaK-STAT pathway
IL2
Drives lymphoid lineage
Important in T cell development
With IL4, induces Th2 cells
IL3
Drives myeloid lineage differentiation
IL4
Induces Th2 cell differentiation
Secreted by Th2 cells
Drives antibody secretion in B cells
IL5
Stimulates B cell proliferation
Activates eosinophils
IL6
Induces fever
Induces production of acute phase proteins from liver
IL7
Drives lymphoid lineage differentiation
Drives T cell differentiation in thymus
What is another name for IL8?
CXCL8
IL8 (CXCL8)
Chemoattractant for neutrophils
IL9
Suppresses apoptosis
Induces proliferation in WBC
IL10
Anti-inflammatory
Secreted by Treg cells to suppress other T cell types
Secreted b M2 type macrophages
IL12
Drives Th1 development
Secreted by M1 type macrophages and Th1 cells
TGF-Beta (Transforming Growth Factor Beta)
Inhibits B cells and M1 macrophages
Induces differentiation of CD4 Th cells into Treg cells and Th17 cells
Tumor necrosis factor
Similar effects as IL1
Can induce apoptosis by binding to its receptor
IFN-alpha and IFN-beta
Type 1 interferons
Activate antiviral responses
IFN-gamma
Type 2 interferon
Secreted by Th1 cells
Important for maintenance of granulomas
