CD Markers and ILs-

Question 1

CD19

Answer 1

B cells

Question 2

CD14

Answer 2

Monocytes

Question 3

CD3

Answer 3

T cells

Question 4

CD4

Answer 4

Helper T cells

Question 5

CD8

Answer 5

Killer T cells

Question 6

CD4+CD25+FoxP3

Answer 6

T regulatory cells

Question 7

CD56

Answer 7

NK cells

Question 8

CD21 (CR2)

Answer 8

B cells

Question 9

CD28

Answer 9

T cells

Question 10

CD154 (CD40L)

Answer 10

T cells

Question 11

CD80/86 (B7.1/B7.2)

Answer 11

Antigen Presenting Cell

Question 12

CD40

Answer 12

B cells, some macrophages

Question 13

IL1

Answer 13

Signs of inflammation
Increased vascular permeability/adhesiveness and diameter
Activates JaK-STAT pathway

Question 14

IL2

Answer 14

Drives lymphoid lineage
Important in T cell development
With IL4, induces Th2 cells

Question 15

IL3

Answer 15

Drives myeloid lineage differentiation

Question 16

IL4

Answer 16

Induces Th2 cell differentiation
Secreted by Th2 cells
Drives antibody secretion in B cells

Question 17

IL5

Answer 17

Stimulates B cell proliferation
Activates eosinophils

Question 18

IL6

Answer 18

Induces fever
Induces production of acute phase proteins from liver

Question 19

IL7

Answer 19

Drives lymphoid lineage differentiation
Drives T cell differentiation in thymus

Question 20

What is another name for IL8?

Answer 20

CXCL8

Question 21

IL8 (CXCL8)

Answer 21

Chemoattractant for neutrophils

Question 22

IL9

Answer 22

Suppresses apoptosis
Induces proliferation in WBC

Question 23

IL10

Answer 23

Anti-inflammatory
Secreted by Treg cells to suppress other T cell types
Secreted b M2 type macrophages

Question 24

IL12

Answer 24

Drives Th1 development
Secreted by M1 type macrophages and Th1 cells

Question 25

TGF-Beta (Transforming Growth Factor Beta)

Answer 25

Inhibits B cells and M1 macrophages Induces differentiation of CD4 Th cells into Treg cells and Th17 cells

Question 26

Tumor necrosis factor

Answer 26

Similar effects as IL1 Can induce apoptosis by binding to its receptor

Question 27

IFN-alpha and IFN-beta

Answer 27

Type 1 interferons Activate antiviral responses

Question 28

IFN-gamma

Answer 28

Type 2 interferon Secreted by Th1 cells Important for maintenance of granulomas