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M1 immunology term 2 quiz 1 > CD/cytokines flashcards > Flashcards

CD/cytokines flashcards

1
Q

What are the main cells that express and what is the function of CD3?

A

all T cells

associate with the TCR and mediate TCR signalling

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2
Q

What are the main cells that express and what is the function of CD4?

A 
T helper cells, MHC class II reactive T cells monocytes, macrophages 
binds to MHC class II and helps in signalling for MHC II reactive T cells
binds to HIV
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3
Q

What are the main cells that express and what is the function of CD8?

A 
CTLs, MHC class I reactive T cells 
binds to MHC class I and helps in signalling for MHC I reactive T cells
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4
Q

What are the main cells that express and what is the function of CD28?

A

T cells

Costimulatory molecule for T cell activation. Binds to CD80 and CD86

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5
Q

What are the main cells that express and what is the function of CD40?

A

B cells, macrophages, DCs Binds to CD154; involved in activation of B cells, DCs, and macrophages

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6
Q

What are the main cells that express and what is the function of CD80 aka b7 and b7-1?

A

B cells, macrophages, DCs Binds to CD28 and CTLA-4. Costimulator for T cell activation.

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7
Q

What are the main cells that express and what is the function of CD86 aka b7-2?

A

B cells, macrophages, DCs Binds to CD28 and CTLA-4. Costimulator for T cell activation.

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8
Q

What are the main cells that express and what is the function of CD95 aka Fas, APO-1?

A

Activated T and B cells, monocytes Induces apoptosis upon interaction with CD178

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9
Q

What are the main cells that express and what is the function of CD154 aka CD40 ligand and CD40L?

A

Activated CD4+ T cells Binds to CD40. Activates B cells, DCs, and macrophages

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10
Q

What are the main cells that express and what is the function of CD178 aka Fas-ligand?

A

Induced on T cells and NK cells Binds to Fas and induces apoptosis on Fas+ cells; important for regulation of the immune response.

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11
Q 
IL-1:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

macrophages, B cells,NK cells endothelium, fibroblasts, astrocytes, etc…
T cells, B cells, macrophages, endothelium lymphocyte activation, macrophage stimulation, incr. leukocyte - endothelium adhesion; acute phase proteins, fever

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12
Q 
IL-2:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

T cells T cells, NK cells T cell and NK cell activation and proliferation

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13
Q 
IL-4:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

T cells, Th2 cells, mast cells B cells, T cells B cell growth factor, isotype switching to IgE, Th2 cell differentiation; suppress Th1 cells

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14
Q 
IL-5:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

T cells, mast cells, Th2 cellsB cells B cell growth factor, isotype switching to IgA; eosinophil growth

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15
Q 
IL-6:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

T, B, macrophages endothelium, fibroblasts, astrocytes, stromal cells etc… T, B, macrophages Induces acute phase response; regulates Th17 differentiation, and proliferation of antibody producing cells

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16
Q 
IL-10:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

T cells, Th2 cells Th1 cells inhibition of cytokine synthesis and macrophage function

17
Q 
IL-12:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

monocytes, APCs Th1 cells, NK cells differentiation of Th1 cells; activation of NK cells

18
Q 
TNF-alpha:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

lymphocytes, macrophages, mast cellsmany cells proinflammatory; endothelial activation, shock, acute phase proteins, PMN activation

19
Q 
TNF-beta:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

T cells, monocytes most cells most cells inhibits cell activation, anti-inflammatory, promotes IgA secretion

20
Q 
Interferon-alpha/Beta:
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

most cells most cells most cells antiviral; increased MHC class I expression

21
Q 
Interferon-γ (gamma):
What is the Main Cell Source?
Other Cell Sources?
Principal Targets?
Principal Effects?
A

NK cells, T cells macrophages, B cells, endothelium, DCs increased MHC class II expression, macrophage activation, IgG class switching, suppress Th2 cells

M1 immunology term 2 quiz 1 (5 decks)

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