abbas chapter 3

Question 1

TNF and IL-1

Answer 1

released by macrophages and epi cells when they recognize microbes
cause dendritic cells to round up and lose adherences to epi cells
move to lymph nodes

Question 2

MHC I

Answer 2

differences between individual is in the alpha 1 and alpha 2 domains of alpha chain
alpha 3 invariant and has coreceptor for CD8
alpha 1 and alpha 2 make cleft - floor of cleft has antigen binding site (can accommodate 8-10 residue chain)

Question 3

MHC II

Answer 3

alpha and beta chains - amino terminal portions = alpha 1 and beta 1
make cleft (can accomidate 10-30 residues)
beta 2 has sites for CD4
only on APC and macrophages and B lymph

Question 4

MHC genes

Answer 4

codominantly expressed
3 polymorphic class I and class II
class I = HLA-A/B/C
class II = HLA-DR/DQ/DP

Question 5

where do MHC proteins acquire cargo?

Answer 5

during biosynthesis
MHC I from cytoplasm
MHC II from intracellular vesicles