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CHEM > CC QUIZ 3 > Flashcards

CC QUIZ 3 Flashcards

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1
Q

Glucagon is release during stress and fasting state, which among the ff. is not an action of glucagon?

a. Formation of Glucose-6-phosphate from noncarbohydrate sources
b. Decomposition of fat
c. breakdown of glycogen to glucose 6 PO4
d. glucose metabolism to pyruvate

A

Glucose metabolism to pyruvate

NOTE:
is glycolysis which is an action of insulin

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2
Q

Which among the ff. is true

a. Type 1 DM occurs exclusively among children
b. Type 1 DM: Undetectable C peptide and absent insulin secretion
c. Type 2 DM: Associated with obesity and sedentary lifestyle
d. Type 2 DM: consistent to have a life threatening DKa

A

Type 2 DM: Associated with obesity and sedentary lifestyle

NOTE:
A – it also occur in some adult
B- insulin is absolute deficient
D – Dka occurs commonly in type 1

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3
Q

Sodium fluoride is ideal for glucose analysis because:

a. It inhibits glycolysis
b. It preserves glucose up to 3 days
c. It is bacteriostatic
d. AOTA

A

AOTA

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4
Q

In glucose oxidase method, what is the reagent enzyme to cause color reaction?

a. Glucose oxidase
b. Hexokinase
c. Peroxidase
d. G6PD

A

Peroxidase

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5
Q

A diabetic patient results are as follow:

i. FBS: 140 mg/dL - NV: <126 mg/dL

ii. RBS: 220 mg/dL -NV: <200mg/dL

iii. Repeated HbA1c : 3% -NV: 4-6%

Note: the patient has Low RBC count and increase reticulocyte count.

The results shown indicate?

a. Test is invalid, FBS and RBS are in conflict with HbA1c result
b. Patient has low glucose due to low HbA1c
c. Rerun HbA1c test
d. HbA1c is invalid due to the CBC result of the patient

A

HbA1c is invalid due to the CBC result of the patient

NOTE:
The patient has hemolytic anemia (low RBC count and high reticulocyte count). Therefore, HbA1c will be falsely low.
Proceed to fructosamine test

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5
Q

In 3hr-OGTT test, the first blood collection is done

a. Before the ingestion of glucose load
b. Right after the ingestion of glucose load
c. 1 hr after the ingestion of glucose load
d. 1 hr before the ingestion of glucose load

A

Before the ingestion of glucose load

NOTE:
fasting plasma glucose
1-hour plasma glucose
2-hour plasma glucose
or a 3-hour plasma glucose

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6
Q

If the blood glucose of a patient is 90 mg/dL, what is his estimated normal CSF glucose?

a. 54 mg/dL
b. 78 mg/dL
c. 110 mg/dL
d. 80 mg/dL

A

54 mg/dL

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7
Q

Common symptoms of Glycogen storage diseases?

a. Cardiomyopathy and macroglossia
b. Renomegaly and Rickets
c. Hypoglycemia and Hepatomegaly
d. Liver cirrhosis and esophageal varices

A

Hypoglycemia and Hepatomegaly

NOTE:
A – pompe
B – Fanconi bickel
D – Anderson

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8
Q

Which among the ff. is not Type B lactic acidosis?

a. Diabetes mellitus
b. Salicylate ingestion
c. Ethanol intoxication
d. CHF

A

CHF

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9
Q

Lipids found in the cell membrane?

a. Phospholipid and TAG
b. Phospholipid and Cholesterol
c. Phospholipid and Lipoproteins
d. Phospholipid only

A

Phospholipid and Cholesterol

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10
Q

Deficiency of lipoprotein lipase will lead to

a. Failure of cholesterol esterification
b. Poor Hydrolysis of TAG to be transferred to adipose tissue
c. Emulsification of fats in the gut
d. Inability to maintain the lipoprotein structure

A

Poor Hydrolysis of TAG to be transferred to adipose tissue

NOTE:
C – bile does the emulsification of fats in the gut
D – apolipoprotein maintains the lipoprotein structure

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11
Q

Acute and recurrent pancreatitis occurs because

a. TAG-rich-chylomicrons are deposited in the capillaries of pancreas
b. TAG-rich-Chylomicrons occlude the pancreatic blood vessel
c. LDL causes plaque in the pancreas
d. AOTA

A

TAG-rich-Chylomicrons occlude the pancreatic blood vessel

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12
Q

GC-MS is the latest reference method for

a. TAG
b. Cholesterol
c. A and B
d. NOTA

A

A and B

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13
Q

Decreased TAG

i.Hyperthyroidism
ii.Malabsorption
iii.Brain infarction
iv.Nephrotic syndrome

a. AOTA
b. i,iii,iv
c. i,ii,iii
d. i,ii

A

i,ii,iii

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14
Q

The major interference in TAG determination?

a. Bilirubin
b. Vit C
c. Hemolysis
d. Glycerol

A

Glycerol

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15
Q

Essential fatty acid that is/are inflammatory regulator?

a. Linoleic (omega 3)
b. Linolenic acid (omega 6)
c. Both a and b
d. Elaidic acid

A

Both a and b

16
Q

True about cholesterol

a. Majority of the cholesterol comes from our diet
b. It is used for the production of progesterone, estrogen, and testosterone
c. For cell membrane pliancy/elasticity
d. Loss of cholesterol leads to spherocytosis

A

It is used for the production of progesterone, estrogen, and testosterone

NOTE:
A – majority comes from the liver
C – for cell membrane tensile, pliancy is phospholipid
D – target cell and acanthocytosis

17
Q

Known interference in cholesterol determination?

a. Ascorbic acid
b. Bilirubin
c. Hemoglobin
d. AOTA

A

AOTA

18
Q

True about lipoproteins

a. The size of lipoprotein is directly proportional to its lipid content
b. Lipid content is inversely proportional to density
c. Density is inversely proportional to the size of the lipoprotein
d. AOTA

A

AOTA

19
Q

Every decade from the age of 20 and above, cholesterol increases by

a. 5 mg/dL
b. 20 mg/dL
c. 30 mg/dL
d. 10 mg/dL

A

20 mg/dL

20
Q

Which apolipoprotein is associated to alzheimer’s disease

a. Apo E2
b. Apo E4
c. Apo B-100
d. Apo B-48

A

Apo E4

21
Q

In lipoprotein electrophoresis, a spike in beta region means

a. An increase in HDL
b. An increase in LDL
c. Normal
d. An increase in VLDL

A

An increase in LDL

NOTE:
Alpha 1 region – HDL
Pre beta region – VLDL
Beta region – LDL
Origin – Chylomicron

22
Q

In ultracentrifugation, what is the ascending order of lipoprotein, in terms of their densities?

a. HDL, LDL, IDL, VLDL, Chylomicron
b. Chylomicron, VLDL, IDL, LDL, HDL
c. HDL, VLDL, IDL, LDL, Chylomicron
d. Chylomicron, LDL, IDL, VLDL, HDL

A

Chylomicron, VLDL, IDL, LDL, HDL

23
Q

the most common medium for separation of intact lipoproteins for it provides a CLEAR BACKGROUND AND CONVENIENCE IN USE.

a. Polyacrylamide gel
b. Agarose
c. Cellulose acetate
d. NOTA

A

Agarose

NOTE:
polyacrylamide gel is used for separation of lipoprotein classes,subclasses, and the apolipoproteins

24
Q

In lipoprotein immunoassay, the reagent antibody in solid phase is specific to

a. Lipoprotein
b. Lipids
c. Apolipoprotein
d. AOTA

A

Apolipoprotein

25
Q

Fasting becomes a requirement if this lipid is present in the test request?

a. Cholesterol
b. LDL
c. TAG
d. B and C

A

TAG

NOTE:
* When TAG and LDL C are being measured, fasting becomes a requirement,
BUT LDL is NOT A LIPID but a protein

26
Q

Increase of this/these is CARDIOPROTECTIVE?

a. HDL
b. Apo A1
c. A and B
d. LDL

A

A and B

27
Q

Order of lipoprotein size/diameter from largest to smallest?

a. Chylomicron, VLDL, LDL, HDL
b. Chylomicron, LDL, VLDL, HDL
c. HDL, LDL, VLDL, Chylomicron
d. Chylomicron, VLDL, HDL, LDL

A

Chylomicron, VLDL, LDL, HDL

28
Q

According to the following results, what condition would probably be suspected?

hypoalbuminemia

Microalbuminuria positive

Oval fat bodies positive

A2­ macroglobulin increase

Increase serum TAG and Cholesterol

Increase BUN and Creatinine

a. Hypercholesterolemia
b. Diabetes mellitus
c. Nephrotic syndrome
d. SLE

A

Nephrotic syndrome

29
Q

End color reaction of Liebermann Burchardt?

a. Blue
b. Red
c. Orange
d. Green

A

Green

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