CBL 4_Pharmacological Pain Management and Induction of Labour Flashcards

1
Q

What is cervix ripening?

A

Process of stimulating

-softening
-effacement
-dilation of cervix, usually prior to induction of labour.

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2
Q

What are some non pharmaceutical methods for ripening the cervix at term?(8)

A
  • Cervical sweeps
  • balloon catheter
  • acupuncture
  • acupressure
  • evening primrose oil
  • castor oil
  • nipple stim
  • sex (with sperm [low level prostaglandins] or not)
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3
Q

What non-pharmacological methods of cervix ripening have research backing them? (4)

A

Castor Oil
Cervical Sweep
Nipple stimulation

Can all reduce the need for IOL

Balloon catheter recommended first line approach by. SOGC

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4
Q

What is the community standard on IOL for postdates?

A

Induction of labour should be offered to all clients at 41 weeks

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5
Q

ICD on postdates management

A

The vast majority of pregnancies aren’t associated with major or long-term complications, and although the chance of complications increases with a postdates pregnancy, the overall risk remains low.

The recommendation is to offer pregnant people with an ICD an induction between 41 and 42 weeks because it reduces the low risk of complication to an even lower risk.

If you choose to wait for labour to start, the recommendation is to monitor your baby to make sure they are well with at least one non-stress test and an assessment of the amniotic fluid starting at 41 weeks, as well as fetal movement counting.

You can choose to induce medically, non-medically, or wait for labour.

If you are waiting for labour to start, you can choose how to monitor your baby.

You can think about what we’ve talked about and take time to make your decision. While making your decision consider what’s important to you. I’m here to answer any questions now or later, and I’ll support you in choosing what feels like the best choice for you.

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6
Q

Options for postdates?

A

1) You can choose to induce labour medically:
· The recommendation is to offer pregnant people an induction between 41 and 42 weeks

2) You can choose to induce labour non-medically
· The recommendation is to offer pregnant people membrane sweeps from 38 – 41 weeks.

3) You can choose to wait for your body to go into labour (this is called expectant management)

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7
Q

Risk of stillbirth w/ expectant mgmt for postdates?

A

40 weeks 0.7/1000
41 wks 1.1/1000
42 weeks 1.9/1000

all rare

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8
Q

What is the ‘community standard’ for fetal monitoring at term?

A

NST and AFI (with FMC) at 41 weeks. (SOGC - Reasonable approach would be at least one NST and some sort of amniotic fluid assessment twice weekly.)

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9
Q

What is the evidence for the use of NSTs, AFI/AFV and BPPs as a means of predicting fetal well-being?

A

NSTs – false negative rates are low (normal NST 1.9/1000 SB within a week after reading); false positive high
BPP and modified BPP – false negative rates low (0.8/1000), but false positive rates high (60%)

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10
Q

What is the evidence for estimating, and inducing labour for, macrosomia for otherwise low risk pregnancies?

A
  • There is no clear consensus in how to identify macrosomia; there are limitations of US prediction of EFW
  • There is conflicting evidence about whether induction for suspected big babies can improve health outcomes
  • A care provider’s “suspicion” of a big baby carries its own set of risks. This perception—whether it is true or false—changes the way the care provider behaves and how they talk about the pregnancy
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11
Q

BC Women’s guidelines for macrosomia?

A

U/S measured > 4000 g may request an induction of labour at 39 weeks.

Caregivers should discuss shortcomings of ultrasound diagnosis of macrosomia.

SOGC Guideline – there is insufficient evidence to recommend IOL at a specific GA for macrosomia; recommend considering Cesarean for >5000g

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12
Q

How accurate is U/S measuring fetal weight at term?

A

sensitivity 56%
specificity 92%
the tendency is to overestimate fetal weight

(+/- 15 %?)

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13
Q
A
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14
Q

SOGC recs for IOL for suspected macrosomia?

A

There is insufficient data to recommend IOL at a specific gestational age for suspected fetal macrosomia.
A risk reduction strategy giving importance to individual patient preferences should be taken.

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15
Q

When might C/S be considered for suspected macrosomia?

A

EFWT >4500 g with GDM
EFWT >5000 g without GDM.

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16
Q

What should an ICD on C/S for macrosomia include?

A
  • The potential maternal morbidity associated with C/S delivery
  • Risk of urinary and anal incontinence
  • Risk of instrumental delivery
  • Risk of shoulder dystocia to the mother and infant
  • Neonatal risks associated with early term birth before 39 weeks
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17
Q

How do care provider, family and other societal influences impact decision making for IOL? How do racism and classism impact decision making for IOL?

A

Care providers/researchers may restrict choices and autonomy is impacted, e.g. race and class:
1) race – e.g. research finding Black women are at more risk of stillbirth, therefore more likely to be induced, rather than providing quality of care to communities that has been shown to reduce stillbirth risk.
“Achieving high quality national guidance also requires an examination of the impact of social, cultural, and political systems on health, wellbeing, safety, access to care, quality of care, and autonomy. ..Racism is a known determinant of health, occurring at systemic and individual levels. Its role in perpetuating the extreme disparities witnessed in maternity care needs to be addressed through “race conscious medicine”
BMJ – response to NICE recommendation in 2021 that all women from ethnic minority backgrounds should consider IOL at 39w even if no complications: “We are deeply concerned that if these recommendations are taken forward uncritically, they could further embed institutional racism in maternity care, strengthen racial biases and stereotypes, legitimise skin tone as clinically meaningful, pathologise healthy pregnancies in women from ethnic minority backgrounds, and undermine choice for black and brown women.”
2) Class:
BMC- The risk of labour induction differs by socioeconomic status, with nulliparous and multiparous women with fewer educational qualifications and those living in lower SEI locations having ‘a greater likelihood of labour induction than women with higher qualifications and women in advantaged electoral wards’

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18
Q

Why is it important to hydrate before an US for postdates?

A

Important to be well-hydrated systemically rather than just having a fully bladder.

We cannot distinguish oligo caused by isolated maternal dehydration vs. placental insufficiency

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19
Q

What are new antenatal FHS guidelines around defining oligo?

A

OLD WAY: AFI less than 5cm = more interventions without improved outcomes

NEW (evidene based way) SDP less than 2cm x 1 cm.

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20
Q

What is oligohydramnios?

A

decreased amniotic fluid for GA
Single deepest pocket less than 2cm (depth) by 1 cm (width)

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21
Q

Should a postdates client with oligo have IOL?

A

Labour induction is recommended in the postdates population when oligohydramnios is present. Induction should be considered as a priority 1 (< 8 hours). Obstetrical consultation is required prior to induction booking.”

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22
Q

What assessments should be done for admission for IOL?

A

Birther vitals
normal NST
abdominal assessment (confirm presenting part) & FM
VE

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23
Q

When may IOL be associated with more negative childbirth experiences? (3)

A

-** delays** in labor induction, delay in transfer to delivery ward, and delay in receiving pain relief
- a **lack of information and choice **as well as feelings of disappointment, anxiety, and neglect
- lack of continous support

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24
Q

Does it make a difference in outcomes if midwives are primary care providers for an IOL? If so, how? (3)

A

YES

  • fewer other interventions –note less need for epidural
  • fewer handovers = better client safety;
  • maximizes health resources, enhances interprofessional practice, etc:
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25
Q

What is the Bishops score?

A

Position - post (0), Mid (1), Amt (2)
Consistency - firm (0), medium (1), soft (2)
Cervical length cm (effacment) = greater than 4 (0), 2-3 (1), 1-2 (2)
Dilation, cm = 0 (0), 1-2 (1), 3-4 (2)
Fetal station = -3 (0), -2 (1), -1/0/spines (2)

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26
Q

What is a favorable Bishops score?

A

7 or higher (associated with successful IOL)

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27
Q

Can the different bishops scores be used interchangeably?

A

No

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28
Q

What are the risks associated with IOL with a lower bishop’s score?

A

Higher rates of failed IOL and C/S

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29
Q

What is considered uterine tachystole in labour?

A

5 or more cx in 10 mins averaged over 30 minutes

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30
Q

Prerequisites for IOL?

A

ICD and consent
Vertex presi
Adequate fetal station
Determine bishop’s score

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31
Q

Components of IOL?

A

Cervical ripening (mechanical and hormonal)
Initiation of Uterine cx

32
Q

Benefits of mechanical ripening?

A
  • Lowest chance of uterine tachy or fetal heart rate change
  • Equally effective as hormonal
33
Q

What is a common contraindication for any hormonal cervical ripening?

A

TOLAC

34
Q

When should outpatient return after cervadil given?

A

1 hour of regular cx or 24 hours if no cx

35
Q

What does SOGC say about miso?

A

“Oral misoprostol in a titratable fashion or oxytocin with amniotomy is the preferred method of induction of labor when the Bishop score is 7 or greater.”

Use oxy OR miso

36
Q

Dose of miso for IOL?

A

20-25 mcg Q 2 hours titrate to ctx

37
Q

What’s better for diagnosing oligo AFI or SPD?

A

SPD

38
Q

How long on monitor prior to IOL?

A

1-2 hours CEFM

39
Q

What pharm pain med shouldn’t be offered in active labour?

A

Morphine/gravol (birth within 3 hours, before active labour)
Make baby a bit groggy during transition

39
Q

How long fentanyl in system?

A

30 mins (remifentanil even shorter)

40
Q

How long morphine in system?

A

3 hours

41
Q

Care after initial dose of epidural?

A

· Positioning:
o During initial 30 minutes after epidural/CSE insertion: Position patient lateral for 15 minutes and then turn the patient to the other side for 15 minutes to ensure equal distribution of epidural medication.
o Following anesthesia-administered top-up: position patient as per Anesthesiologist recommendation.
Assess, monitor and document the following:
o Fetal heart rate every 5 minutes for 30 minutes, then as per policy.
o Blood Pressure, Pulse, Respirations every 5 minutes x2, then every 10 minutes x2.
o Sensory, motor, pain and sedation levels at 5 minutes, 20 minutes and then every hour

42
Q

Care during maintenance of epidural?

A

· The patient must remain in bed and rest for a minimum of 30 minutes after the initial dose of epidural medication and following all epidural top-ups administered by the anesthesiologist prior to ambulation.
· Assess the patient for ambulation criteria (see 1.6).
o If the patient does not wish to ambulate, reposition frequently to maximize labour progress.
· Assess, monitor and document the following:
o Fetal heart as per policy.
o BP, pulse, respirations every hour.
o Sensory levels, motor levels (using OB modified Bromage scale), sedation and pain scores every hour.
o Epidural pump details: PIEB, PCEA attempts, PCEA given, hourly totals infused, cumulative volume as per PIEB record (see Appendix A).
o Progression of labour, as clinically indicated.
o No additional vital signs or levels are required after Epidural PCEA dose(s) self-administered by the patient.

43
Q

Assessing epidural sensory. and motor block?

A

o Using ice, first test the patient’s cheek for baseline sensation to cold.
o Starting from the anterior mid-thigh (L2), run the ice continuously towards the patient’s head until the patient can feel the same degree of coldness as baseline. Test bilaterally for complete sensory level assessment and document this level as sensory block height on the PIEB record

Motor function/block:
o Assess motor function while lying in bed using the OB modified Bromage score. Test each stage in order and document score on the PIEB record.
§ Ask the patient to move their feet or leg.
§ Ask the patient to bend their knee bringing their heel towards their buttocks.
§ Ask the patient to complete a straight leg raise against gravity.
§ Ask the patient to complete a straight leg raise while applying a moderate amount of resistance pressure on the patient’s shin
§ Repeat all steps on other leg.

44
Q

Does Cochrane review support use of miso for IOL?

A

Yes

45
Q

Bishops score 7 or bigger next step?

A

Miso or Oxy

46
Q

Bishop’s score less than 7?

A

Balloon, miso, or cervidil

47
Q

Balloon outpatient or in patient?

A

Outpatient (w no other risk factors) 12-24 hours

48
Q

Miso inpatient or outpatient?

A

Inpatient

49
Q

Cervidil inpatient or outpatient?

A

Gel every 6 hours, mesh every 24 hours outpatient

50
Q

PO PGE or PGE insertion labour care?

A

Routine

51
Q

What are the precautions around oxytocin?

A

It NOW lol hazardous:

  • proper labelling
  • HCP avoid if preg
  • handle with double gloves, gown, mask, and eye protection (not going to happen)
52
Q

Are WBCs higher in labour?

A

Yes it is normal to be higher in labour and preg

53
Q

Routine tests for IOL?

A

Type and Screen
CBC

54
Q

WBC levels in labour?

A

8.2-25.8 with slow decrease in first week PP to prepregnant levels

55
Q

Cohort studies on epidural and risk of C/S?

A

While RCTs agree that the use and/or timing of epidural analgesia does not
appear to affect c/s rates, these studies have high crossover and drop out rates.

Cohort studies
that control for confounding factors demonstrate a 2-3 fold increase in c/s

Data from Ontario midwives show’s 2x rate of C/S for IOL nulips

56
Q

How much fentanyl in labour?

A

0.5-1 mcg/kg IV q 10 min during ctx

(70 kg person = 35-75 mcg q 10 mins)

57
Q

How do you prepare fentanyl?

A

100 mcg to 8 mL normal saline to obtain:

10 mL solution w [ ] of 10 mcg/mL

58
Q

Max dose of fentanyl?

A

100 mcg single dose

200 mcg over an hour

400 mcg given- consider epidural

59
Q

What should you consider with postdates IOL?

A

When considering postdates IOL, consider other risk factors/indications, e.g. macrosomia (level 3/not as urgent) vs. oligohydramnios*, which is a clear indication for immediate in person IOL.

60
Q

How long should you monitor after hormonal or mechanical cervical ripening?

A

1 hour

61
Q

What is an indication for cervical ripening?

A

BS 6 or under

62
Q

What does a Bishop’s score of 7 or more indicate?

A

A Bishop’s score of 7 or greater is associated with more chance of a successful induction with AROM & oxytocin.

63
Q
A
64
Q

What is the outcome when midwives are the primary care for IOL? (3)

A

Reduction in interventions:

  • assisted delivery
  • episiotomy
  • need for pharmacological pain relief ( e.g. epidurals)
65
Q

Where is cervadil placed specifically?

A

Fornix

66
Q

Outline pharm pain options for labour? (6)

A
  • Tylenol: early labour
  • Morphine+Gravol: early labour
  • Nitrous Oxide:
  • Fentanyl IV: active labour
  • Pudendal block: local anesthetic injected into pudendal nerve in vagina; can be used in 2nd stage; often used for forceps/vacuum-assisted birth; rapid onset, local pain relief
  • Epidural: neuraxial analgesia; mix of regional anesthetic and opioids
67
Q

Dosage of tylenol in labour?

A

1g PO/Q4hrs, max 4g/Q24hrs

68
Q

Describe gravol used for labour?

A

works within 20-30 minutes for 4 hours; neonatal resus if precipitous birth to follow due to long half-life; side effects: nausea, vomiting dizziness (insert Gravol), Gravol ->drowsiness; Morphin 15-20mg IM Q4hrs; Gravol 25-50mg IM or IV Q4hrs, max 100 mg

69
Q

Describe NO used for labour?

A
  • Nitrous Oxide: easy to use/discontinue; reduces intensity of experience; no adverse effects on NB; most effective in later first stage; needs filtration system; can cause dizziness/light-headedness
70
Q

Describe fentanyl for labour?

A

reduces pain, quick onset, short duration (45-60min); drowsiness, respiratory depression, nausea, itchy; IV admin or PCA pump

71
Q

Pre admin procedure for fentanyl?

A

Pre-admin: VS and sedation scale; VE within last hour (do not administer if birth expected in next 30 min)

72
Q

Post admin procedure for fentanyl?

A

Post-admin: monitor 02 sats for 10min after each dose; BP, HR, RR at 5 and 15 post dose, Q15min until 1 hour after last dose, q1h until 4 hours after last dose
- Naloxone should be readily available

73
Q

Describe pudenal block for labour?

A

local anesthetic injected into pudendal nerve in vagina; can be used in 2nd stage; often used for forceps/vacuum-assisted birth; rapid onset, local pain relief

74
Q

Describe epidural for labour?

A

neuraxial analgesia; mix of regional anesthetic and opioids
- Indications: client request, exhaustion, systemic diseases where stress may be dangerous, hypertension; breech, fetal anomalies, multiples, dystocia
- Contraindications: client lack of consent/refusal, systemic infection, local infection, coagulopathy, anesthetic allergy, increased intracranial pressure, lack of skilled practitioner

75
Q

Pre admin procedure epidrual?

A

mat VS, FHR, emply bladder, place IV

76
Q

Post admin procedure epidural?

A

BP immediately after, q5min within 30min block to r/o hypotension, FHR q5min, bladder emptied regularly