CBio [016] Tumor Vasculature and Therapeutic Strategies

Question 1

Give examples of Anti-angiogenic factors

Answer 1

• thrombospondin-1
• angiostatin

-IFN-α

Question 2

Give examples of Pro-angiogenic factors

Answer 2

-VEGF

-bFGF

-IL-8

Question 3

The size threshold after which tumors must need Angiogenesis to grow?

Answer 3

• Required for tumor growth (>1mm3) and metastasis

Question 4

A fluorescent used to visualize the Leakiness?

Answer 4

fluorescent dextran

Question 5

EM of vasculature, mention the differences and identify which is normal tissue and which is not

Answer 5

Question 6

Answer 6

Question 7

Discuss the metabolic switch that happens in tumors

Answer 7

Question 8

What is HIF-1

Answer 8

hypoxia-inducible transcription factor 1

Question 9

Answer 9

Question 10

What does VEGF stand for

Answer 10

Vascular endothelial growth factor (VEGF)

Question 11

What is Bevacizumab

Question 12

What is Bevacizumab

Answer 12

VEGF Targeting antibody

Question 13

What is Combretastatin-A4

Answer 13

Vascular Disrupting Agents (VDAs)

Question 14

Give 3 examples of VEGFR inhibitors

Answer 14

-Sorafenib (Nexavar)

• Sunitinib Malate (Sutent)
• Cedirinib (AZD2171)

Question 15

Give an example of PDGFR inhibitors w

Answer 15

Imatinib Mesylate

Question 16

What is PDGFR

Answer 16

Platelet-derived growth factor receptor

Question 17

Give an example of VEGF antibody

Answer 17

Bevacuzimab (Avastin)

Question 18

Give an example of VEGFR AB antibody

Answer 18

Ramicurimab

Question 19

Describe what you see

Answer 19