Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

GDC > CBio [004] a & b Tumor Immunology > Flashcards

CBio [004] a & b Tumor Immunology Flashcards

1
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Define Immunosurveillance

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

The three possible outcomes of Immunosurveillance?

A

elimination, equilibrium, and escape

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is RAG?

A

recombination-activating gene-2 (RAG2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

So, what is the role of the RAG gene in normal lymphocytes?

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is methylcholanthrene?

A

A chemical carcinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Other examples of co-inhibitory other than CTLA-4?

A

PD-1 and LAG-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

PD-1 stands for?

A

programmed cell death -1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

FOXP3 mutations are x-linked

A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Action of TGF-Beta 1?

A

TGF-Beta 1: Inhibit proliferation and effector function of T cells Inhibit the activation of macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Action of IL-10?

A

IL-10: It is an inhibitor of activated macrophages and dendritic cells Inhibit the expression of co-stimulators and class II MHC molecules on dendritic cells and macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

The T-cell ligand binding B7 on a professional antigen-presenting cell is:

A. CD28

B. CD2

C. LFA-1

D. ICAM-1

E. VCAM-1

A

A. CD28

17
Q

The main costimulatory signal for activation of resting T-cells is provided by ligation of:

• A CD28

• B Surface Ig

• C LFA-1

• D VLA-4

• E IL-2

A

• A CD28

18
Q

The normal immunological control of tumors is referred to as:

• A Immunological tolerance.

• B Immune surveillance.

• C Type III hypersensitivity.

• D Immunological silence.

• E Superantigen recognition

A

• B Immune surveillance

19
Q

Cells bearing MHC class I plus peptide are targets for specific:

• A B-cells

• B Cytotoxic T-cells

• C Th1 cells

• D Th2 cells

• E Interdigitating dendritic cells

A

• B Cytotoxic T-cells

20
Q

What is Ipilimumab?

A

anti-CTLA-4

21
Q
A
22
Q

What is Nivolumab?

A

PD-1 monoclonal Ab

23
Q

Tumors whom Combination therapy of Ipilimumab (a CTLA-4) and Nivolumab (a PD-1) were proven effective?

A

advanced melanoma

24
Q

Which of the following does not describe a documented mechanism of tumor-mediated immune evasion?

A. Down regulation of MHC class I

B. Secretion of TGF-Beta

C. Increase T reg

D. Antigenic variation

A

D. Antigenic variation

25
Q

Tumor editing is one of the most difficult clinically relevant problems to overcome in the course of tumor therapy. Which one of the following accounts for the mechanism of tumor editing?

A. Survival of tumors with moderate expression of class II MHC molecules

B. Survival of tumors with low expression of class I MHC molecules

C. Survival of tumors with low expression of class II MHC molecules

D. Survival of tumors with high expression of class II MHC molecules

E. Survival of tumors with moderate expression of class I MHC molecules

A

B. Survival of tumors with low expression of class I MHC molecules

GDC (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions