Causes Flashcards
4 most common causes of cirrhosis in Australia
- Alcohol
- Hep C
- NASH
- Hep B
5 Causes of Upper GI bleeding
- PUD
- Varices
- Esophagitis
- Mallory Weiss tear (tear in oesophagus)
- Other: Ca, angiodysplasia/AVM
Causes of Positive Trendelenburg (3)
- OA
- Proximal myopathy (expect to see it bilaterally)
- Lesion to superior gluteal nerve
Common causes of bilateral clubbing (5)
CARDIOVASCULAR
- Cyanotic congenital heart disease
- Infective endocarditis
RESPIRATORY 3. Lung carcinoma (usually not small cell carcinoma) 4. Chronic pulmonary suppuration: • Bronchiectasis • Lung abscess • Empyema 5. Idiopathic pulmonary fibrosis
Causes of unilateral clubbing (3)
- Bronchial arteriovenous aneurysm
- Axillary artery aneurysm
- Hemiplegia
Causes of an Ejection Systolic Murmur (4)
- Can be innocent in children or pregnancy
- Aortic stenosis/sclerosis
- Pulmonary stenosis
- H(O)CM
Causes of a pan systolic murmur (3)
- mitral regurg
- triscupid regurg
- ventricular septal defect
Causes of an early diastolic murmur (2)
- aortic regurgitation
- pulmonary regurgitation
If 2^ to pulmonary HTN resulting from mitral stenosis. It is called Graham Steell murmur
Causes of a mid diastolic murmur (4)
- mitral stenosis
- rheumatic fever (Carey Coombs - thickening of valves)
- Aortic regurgitation (Austin Flint - fluttering of mitral valve as blood flows back)
- Tricuscpid stenosis
Causes of a tricuspid regurgitation (5)
- Rheumatic heart disease
- Infective endocarditis (especially in IVDU)
- Ebstein’s anomaly (a congenitally malpositioned tricuspid valve)
- Other congenital abnormalities of the AV valves
- Dilated RV
Causes of High Anion-Gap Acidosis (4)
- ketoacidosis
- lactic acidosis
- renal failure
- toxins
Causes of Normal Anion-Gap Acidosis (8)
- Renal tubular acidosis
- Carbonic anhydrase inhibitors
- Severe diarrhoea
- Uretero-enterostomy or Obstructed ileal conduit
- Drainage of pancreatic or biliary secretions
- Small bowel fistula
- Recovery from ketoacidosis
- Addition of HCl, NH4Cl
5 Causes of interstitial lung disease (5)
- Chemicals: silicosis, asbestosis
- Drugs: amiodarone, methotrexate, chemotherapy
- Idiopathic
- Radiotherapy
- Connective tissue disease
4 causes of seizures in an Alcoholic (4)
- Alcohol withdrawal
- Hypoglycemia
- Electrolyte disturbances - esp hypoMg, hypo Ca
- Trauma
10 Alcohol related organ damage/effects
Brain:
- Wernicke’s encephalopathy
- Korsakoff’s syndrome
- Cerebella ataxia
- Sensory neuropathy
- Alcoholic dementia
Heart:
6. Alcoholic cardiomyopathy
Abdomen:
- Hepatitis/Cirrhosis
- Pancreatitis
- Proximal myopathy
- Psychosocial effects
Uncommon causes of bilateral clubbing
RESPIRATORY
- Cystic fibrosis
- Asbestosis
- Pleural mesothelioma (benign fibrous type) or pleural fibroma
GASTROINTESTINAL
- Cirrhosis (especially biliary cirrhosis)
- Inflammatory bowel disease
- Coeliac disease
THYROTOXICOSIS
Familial (usually before puberty) or idiopathic
Rare causes of bilateral clubbing (3)
- Neurogenic diaphragmatic tumours
- Pregnancy
- Secondary parathyroidism
3 most common causes of chronic cough
- Post nasal drip
- GORD
- Asthma
Causes of pericarditis (10)
- infection
- post MI (acute and dressler’s)
- malignancy
- uraemia
- autoimmune
- post radiation
- post surgical (post cardiotomy)
- post trauma
- familial and idiopathic
- chylopericardium
5 major causes of Hemoptysis
Tumours
Infections:
- TB
- Pneumonia
- Bronchiectasis
- Infective bronchitis
Infarction:
- PE
Pulmonary oedema:
- LV HF
- Mitral stenosis
Pulmonary vasculitis:
- Wegner’s granulomatosis
- Goodpasture’s syndrome
Causes of RAPD (3)
- Optic neuritis
- Retinal detachment
- MS
(An acute problem)
6 causes of Hypoxemia
- Low FiO2 - postop, high altitude
- Hypoventilation - drug OD
- Shunting - pneumonia, ARDS, pulmonary HTN { R) to L) }
- Low mixed venous O2 content - shock
- V/Q mismatch - COPD
- Diffusion impairment - ILD, emphysema
4 causes of Hypercapnia
- High Inspired CO2 -postop
- Low Total Ventilation - COPD, asthma, CF, central, muscle disorders, fatigue
- High Deadspace Ventilation - rapid shallow breathing
- High CO2 Production
5 Causes of LAD (left axis deviation)
Left anterior hemiblock Inferior MI VT from LV focus WPW syndrome LVH
5 Causes of RAD (right axis deviation)
RVH Pulmonary embolism Anterolateral MI WPW syndrome Left posterior hemiblock (rare)
Causes of prolonged QT
- Acute MI
- Myocarditis
- HF
- Bradycardia (eg AV block)
- Head injury
- Hypothermia
- Elec imbalance (low K+, Ca2+, Mg2+)
- Congenital
- Drugs
Drug causes of prolonged QT
sotalol
amiodarone
quinidine (antiarrhythmic)
quinines (antimalarial)
antihistamines
macrolides (eg erythromycin)
tricyclics
Only bacteria to cause ulcers
Mycobacterium ulcerans
–> causes a Buruli ulcer
Causes of sudden onset stridor (4)
obstruction of the larynx/trachea
- anaphylaxis
- toxic gas inhalation
- acute epiglottis
- inhaled foreign body
Causes of gradual onset stridor (6)
obstruction of the larynx/trachea
- laryngeal or pharyngeal tumours
- cricoarytenoid RA
- bilateral vocal cord palsy
4, tracheal carcinoma - paratracheal compression by lymph nodes
- post tracheostomy or intubation granulomas
Causes of kyphoscoliosis (3)
- idiopathic (80%)
- Secondary to Polio
- Marfans
Causes of bronchial breathing (4)
- consolidation
- localised pulmonary fibrosis
- pleural effusion (above the fluid)
- collapsed lung
6 Causes of reduced breath sounds
- COPD (emphysema)
- malignancy
- pleural effusion
- pneumothorax
- pneumonia
- pulmonary collapse
Cause of early inspiratory crackles
COPD (characteristic)
Causes of late/pan inspiratory crackles
disease of alveoli
eg. interstitial lung disease
Most common causes of CCF (5)
CAD HTN Idiopathic (often dilated cardiomyopathy) Valvular (e.g. AS, AR and MR) Alcohol (dilated cardiomyopathy)
Causes of peripheral oedema (5)
- Cardiac failure
- Venous insufficiency
- Hypoalbuminemia: nephrotic syndrome, liver disease, protein losing enteropathy
- Lymphatic obstruction
- Drugs:
a) Na retention - NSAIDs, fludrocortisone
b) Increase cap permeability - nifedipine, amlodipine
Causes of hypokalaemia (7)
- Kidney disease
- Gastrointestinal loss: vomiting, diarrhoea
- Alkalosis
- Mineralocorticoid excess: Cushing syndrome, ↑ aldosterone, Conn syndrome
- Loss in extracellular fluid to intracellular (e.g. burns, other trauma)
- ↓ Intake of K+
- Drugs (e.g. diuretics—frusemide, thiazides)
Causes of hyperkalaemia (5)
- Kidney failure - decrease eGFR, decrease excretion
- Acidosis (especially metabolic) - drives K out of cells
- Mineralocorticoid deficiency: Addison disease, aldosterone antagonists (decrease excretion)
- Excessive intake of K+ (e.g. ↑IV fluids with K)
- Drugs (e.g. spironolactone, ACE inhibitors, NSAIDs)
Causes of unilateral pleural effusion (4)
- heart failure (at the beginning)
- cancer
- infection
- asbestosis
Causes of AF
- Heart failure
- MI
- Hypertension
- mitral valve disease
- PE
- Pneumonia
- Hyperthyroidism
- Caffeine
- Alcohol
- post-op
- Low K+
- Low Mg2+
‘Lone’ AF means no cause found
Causes of impaired wound healing
- arterial insufficiency
- venous insufficiency
- pressure
- infection
- diabetes
- nutritional
- radiation
- drugs inc steroids
- smoking
Causes of seizures
VITAMIN
Vascular: Stroke, Post Stroke, AV Malformations
Infection: Meningoencephalitis, meningitis, brain abscess, HIV related, Cerebral Malaria
Trauma: Brain injury
Autoimmune: SLE, CNS Vasculitis
Metabolic: Hepatic Encephalopathy, Uremia, Hypoglycemia, Low Na, Ca, Mg, Alcohol/Drug withdrawal
Idiopathic: Epilepsy
Neoplasm: Primary brain tumour, Secondaries from breast, lungs, GIT
pSeudoseizures
4 causes of hypercalciuria
- hypercalcaemia
- excessive dietary intake of calcium
- excessive resorption of calcium from the skeleton, such as occurs with prolonged immobilization or weightlessness
- idiopathic hypercalciuria.
Causes of T wave inversion
- Normality
- Ischaemia
- Ventricular hypertrophy
- Bundle branch block
- Digoxin treatment.
Causes of sinus bradycardia
Physical fitness
Vasovagal attacks
Hypothermia
Hypothyroidism
Causes of sinus tachycardia
Exercise, pain, fright Obesity Pregnancy Anaemia Thyrotoxicosis CO2 retention