Catabolism of Nucleotides & Heme Flashcards
Two steps for purine catabolism involve which two process?
Deamination and oxidation
Which two enzymes are involved in these deamination and oxidation? (for adenosine)
ADA (Adenosine DeAminase) and xanthine oxidase
ADA deficiency represses _____ and _____ .
reduction of other NTPs
T/B cell proliferation (immune system)
____ inhibits xanthine oxidase to prevent ____.
Allopurinol, uric acid crystal formation (gout)
Unlike purines, pyradine completely catabolized in TCA cycle through ____
succinyl coa
The enzyme used in purine recycle is called _____. Mutations of this CAUSEs this syndrome called _____ which could cause _____
(hypoxanthine) + (guanine) + Phosphoribosyltransferase (HGPRT)
Lesch-Nyhan syndrome
- Overproduction purine ring
- Gout + CNS problems
Thymidine Salvage enzyme ____.
Thymidine kinase
TK1 used as a marker how?
- Increase levels in high proliferation
- cell cycle regulated
- required for DNA replication
- target for cancer chemotherapy
Every cell has heme, thus trauma in muscles will collect heme in the blood in the form of ____ through liver conversion.
bilirubin
Clinical diseases for the cause of jaundice can include G6PD deficiency because…
increased RBC cell lysis, releasing heme into the blood stream
Jaundice is called ____ due to lack of metabolism of it. It can occur in infants because?
hyperbilirubinemia
- Infants might not have developed hepatocytes
- increase hemoglobin breakdown (different expression of genes)
Jaundice can occur in adults from? (3)
- Tumor in bile duct blocks bile going through (excretion method of bilirubin)
- Trauma (heme released into blood in large quantities)
- Alcohol abuse (damaged liver tissues)
Identifying clinical jaundice symptoms? (3)
- yellow nails
- Urine very brown or yellow
- yellow skin pigmentation
