Catabolism AA - Urea Cycle

Question 1

4 forms of excreting nitrogen in humans.

Answer 1

• Bilirubin
• UREA (major)
• uric acid
• ammonia

Question 2

All transamination reactions require what cofactor?

Answer 2

Vitamin B6, (PLP)

Question 3

Muscles generate a lot of ammonia and will pass these nitrogen compounds to the blood and to the liver in the form of _____.

Answer 3

alanine

Question 4

The liver converts alanine to _____ using a-KG transamination to _____.

Answer 4

pyruvate. glutamate

Question 5

The transamination enzymes in the liver are ____ and ____. Functions of each?

Answer 5

ALT - alanine transaminase (convert alanine to pyruvate and a-KG to glutamate) Thus dubs this enzyme GPT (glutamate-pyruvate transaminase)

AST - aspartate transaminase