Case related questions

Question 1

how does hypertension affect periodontitis

Answer 1

• can contribute to the development and severity of periodontitis
• causes changes in blood flow and microcirculation within the gums, leading to tissue damage and inflammation,
• creates an environment where gum disease can more easily progress
• this connection is largely due to the shared inflammatory pathway between the two conditions, where both can trigger the release of pro-inflammatory cytokines in the body

Question 2

how does amlodipine affect periodntitis

Answer 2

It is calcium channel blocker used to treat hypertension
- can negatively impact periodontitis by causing gingival overgrowth
- can worsen existing periodontal disease by making it harder to maintain proper oral hygiene and potentially leading to increased plaque accumulation and inflammation around the gums
- this effect is more pronounced in patients with poor dental hygiene already present.

Question 3

How does amlodipine cause gingival overgrowth

Answer 3

• Amlodipine reduces Calcium cell influx
• This leads to reduction in the uptake of folic acid
• This limits the production of active collagenase.
• Because of reduction in degradation, collagen accumulates in connective tissue matrix of gingiva.