case 6- dioxins and BPA Flashcards
What can dioxins cause?
-reproductive problems
- developmental problems
- damage to immune system
- cancer
- interference with hormones
How can dioxins end up in our body?
- industrial origins
- it gets absorbed by earth and by plants
- gets into animal food
- animal ingest these food
- human eat the food
What are the acute effects of Dioxins?
- cloracne
- liver dysfunction
What are chronic effects of Dioxins?
- diabetes
- cancer
- high blood pressure
- heart disease
- birth defects
What are the effects of Dioxin on babies/pregnant women?
- impairs normal development
- dissolves in breastmilk
- impairs nervous system
What are the effects of dioxin on children/ adolescents
- impaired immune function
- impaired endocrine function
- impaired reproduction
What does xenobiotic mean?
foreign chemical
What are the subunits that dissociate in contact with TCDD in the AhR complex?
2 HSP90 and 1 XAPR
What are the 2 phases in which biotransformation occurs?
phase 1: enzyme adds functional group to xenobiotic, oxidation and reduction
Phase 2: glucuronidation occurs, glucuronic acid is mixed with the toxins. decrease of half life of the chemical
What is BPA?
bisphenol A, it is an endocrine disrupting chemical by mimicking the actions of oestrogen
What are the origins of BPA?
- pesticides
- plasticizers
- linings of metal foods
- cosmetics
- supplements for live stock
- pharmaceutical drugs
- soy products
What are the long term effects of BPA?
- metabolic diseases (diabetes)
- CVD (cardiomyopathy)
- reproduction abnormalities ( premature birth)
- developmental abnormalities (asthma0
- others like thyroid abnormalities
How can BPA cause/increase risk of T2DM?
possible through hightening of ERstress and Mitochondrial stress in pancreatic cells. Causing deregulation of cell function resulting in T2DM
