Cascades Flashcards
What happens when factor VII comes into contact with ECM?
It is activated and through a sereis of tissue factor activations, turns pro-thrombin to thrombin.
Which pathway involves factor XII?
Intrinsic coagulation pathway
What happens when lipoprotein is damaged?
Factor VII is activated, eventually activating pro-thrombin to thrombin
Which pathway involves factor VII?
Extrinsic coagulation pathway
What is involved in the common coagulation pathway?
Activated thrombin converts fibrinogen to fibrin, from which clots are formed. Activation of other factors also occurs to amplify coagulation and increase platelet aggregation.
What is the anti-clotting cascade called? What does it involve?
Fibrinolysis
Converts plasminogen to plasmin which degrades factors V and VII and breaks down fibrin. Cleavage of C3 promotes inflammation.
What is haemophilia?
Inherited factor VIII deficiency (X linked)
What 3 chemicals activate complement?
Mannan-binding lectin, ab-ag complex and endotoxin
Which chemical causes the alternative complement pathway?
Endotoxin
What does C3b do?
Opsonisation
What do C3a and C5a do?
chemotaxis, activation of leucocytes and endothelial cells, mast cell degranulation
what does the membrane attack complex do?
Cause lysis of bacteria by forming a pore in the cell wall (using C5b, C6, 7, 8 & 9)
What compound does the kinin cascade use?
Bradykinin
What activates bradykinin?
Activated factor XII
Actions of bradykinin
pain, vascular dilation and permeability, activates plasmin
