Cartilage Flashcards
Type of cartilage that provides a low-friction surface, participates in lubricating synovial joints and distribute applied forces to the underlying bone
Hyaline cartilage
Is a form CT composed of cells called Chondrocyte and a highly specialized extracellular matrix
Cartilage
Disease is characterized by chronic joint pain with various degree of joint deformity and destruction of the articular cartilage
Osteoarthritis
Facilitates fibril interaction with the matrix PG molecules (Hyaline cartilage)
Type 9 collagens
Regulates fibril size (Hyaline cartilage)
Type 11 collagens
Organizes the collagen fibrils into a 3D hexagonal lattice that is crucial to its successful mechanical fnx
Type 10 collagens
Also found in the matrix, mainly at the periphery of the chondrocytes where it helps to attach these cells to the matrix framework
Type 6 collagens
Hyaline cartilage matrix is _____ to provide resilience and diffusion of small metabolites
Highly hydrated
Characteristics that allow the cartilage matrix to respond to varying pressure loads and contribute to cartilage’s weight-bearing capacity
High degree of hydration and the movement of water in the matrix
Specialized cells that produce and maintain the extracellular matrix
Chondrocytes
A ring of a more densely staining matrix located immediately around the chondrocytes
Capsular or Pericellular matrix
A region that is more removed from the immediate vicinity of the chondrocytes. It surrounds the isogenous group.
Territorial matrix
A region that surrounds the territorial matrix and occupies the space between isogenous groups
Interterritorial matrix
A pressure-resistant region closest to the articular surface
Superficial or tangential zone
Lies below the superficial zone and contains round chondrocytes randomly distributed within the matrix
Intermediate or transitional zone
Characterized by small, round chondrocytes that are arranged in short columns perpendicular to the free surface of the cartilage
Deep or radial zone
Is characterized by a calcified matrix with the presence of small chondrocytes
Calcified matrix
The site of hyaline cartilage formation is recognized initially by an aggregate of mesenchymal or ectomesenchymal cells
Chondrogenic nodule
Triggers differentiation of these cells into chondroblast
Expression of transcription factor SOX-9
The process that forms new cartilage at the surface of an existing cartilage
Appositional growth
The process that forms new cartilage within an existing cartilage mass
Interstitial growth
