Cardiovascular Pathology Flashcards
most expensive CVD
heart disease
biggest % breakdown attributable to CVD is in what?
coronary artery disease
top 4 health behaviors that affect CVD
1] smoking
physical inactivity
nutrition
obesity
health/risk factors for heart diseases and strokes
family hx, genetics high cholesterol HTN diabetes mellitus metabolic syndrome
3 factors, 1 is present in almost 50% of CVD deaths
blood pressure
cholesterol
smoking
1 modifiable risk factor for hemorrhagic and ischemic strokes
HTN
defined as high BP, against the walls of the arteries
HTN
idiopathic HTN is what kind and what %
primary HTN
90-95% of cases
BP for HTN?
more than 140/90
identifiable cause
5-10% of cases
secondary HTN
ratio for HTN
1 in 3
ages 12-19 year olds have really poor score in what?
healthy diet score
signs and symptoms of HTN
headache vertigo flushed face blurry vision nocturnal urinary frequency
HTN prevention
PA/ exercise
weight control
diet modification
HTN diagnosis
BP CBC urinalysis serum cholesterol fasting blood glucose ECG
HTN treatment
ongoing medication
lifestyle modification
HTN prognosis
can lead to L ventricular hypertrophy
transport of cholesterol to cells
LDL
transports form body to liver
HDL
increased risk of CAD with what kind of cholesterols?
high LDL
low HDL
total cholesterol should be #
less than 200
LDL #
less than 160
HDL # for males and females
more than 40 for males
more than 50 for females
triglycerides #
less than 150
CO binds 250 times more readily to Hgb vs. oxygen
oxyhemoglobin curve
chronic hypoxia leads to?
increased HCT and increased risk of clots
CO damages?
epithelial lining
decreased coronary flow at rest and with exercise
increased HTN
vasoconstriction
family hx: higher risk of a relative who had their first coronary event are what ages?
less than 55 y/o for males
less than 60 y/o for females
first sign of coronary artery disease is..?
fatty streak
stable vs. unstable
stable= injury to one area unstable= formed and now floating around
plaque vasoplasm decreased CO low oxygen levels - lung disease
oxygen supply
exercise/activity
psychological stress
oxygen demand
causes:
total occlusion of artery
platelet activation with limited blood flow
vasospasm of diseased artery/pain
angina
consistent workload precedes ischemia
reduced by rest
stable angina
lower workload precedes ischemia
OR lasts longer
OR different quality
»women
unstable angina
necrosis
weak vulnerable 10-14 days
fibrous scar 6-8 weeks
zone of infarct
may return to normal but susceptible to necrosis
regain function 2-3 weeks
zone of hypoxic injury
reversible zone
may have ECG changes but return to normal as heals
zone of ischemia
treatment for MI
improve blood flow with drugs
PTCA
stent
battery operated, mechanical pump, surgically implanted
- pulsatile
- nonpulsatile
LVAD
pathologic conditions of bv for extremities and abdominal organs
peripheral vascular disease
categories of peripheral vascular disease
inflammatory
arterial occlusive
venous
vasomotor
atherosclerosis occlusive disease of peripheral aa to legs
peripheral artery disease
symptoms: intermittent claudication, pain, parasthesia, paralysis, diminished pulses, pallor, silent ischemia
peripheral artery disease
ABI stands for?
ankle brachial index
greater than 1.4 ABI
clarification/vessel hardening
0.5-0.8 ABI
moderate arterial disease
less than 0.5 ABI
severe arterial disease
after DVT
varicose veins, neoplasm in pelvis
venous stasis
Sx:
Progressive edema of leg (hardened)
Thickening, brown pigmentation of skin at ankles
Venous stasis ulceration
chronic venous insufficiency
Intermittent small artery constriction of the extremities with temporary
pallor and cyanosis of the
fingers/toes
Raynaud disease
Disturbs vascular reflexes
Vasoconstriction/vasospasm
Deoxygenated blood pools
Raynaud disease
Sx: nail beds brittle, fingertips roughened
Usually bilateral sx
Raynaud disease
Dx: clinical presentation and PMH
Raynaud disease
Tx: manage symptoms, PT
Raynaud disease
chronic regional pain syndrome symptoms
skin color
swelling
temperature changes in extremities
allodynia
narrowing or constriction of valve to prevent full opening; caused by scars or
abnormal deposits
stenosis
mitral valve thickened opens early in diastole
murmur
Dx: ECG, doppler
mitral stenosis
Heart unable to pump sufficient blood supply– Pulmonary congestion, HTN
– Group of symptoms not disease
congestive heart failure
4 types of CHF
1] systolic HF
2] HF with preserved ejection fraction (diastolic)
3] L sided HF (cardiac output)
4] R sided HF (pulm disease)
CHF=?
L ventricular failure
acute R ventricular failure like massive PE
cor pulmonale
Risk factors: – Middle aged women due to HTN, renal issues and DM – Steroid, NSAIDs – Diet – PE
CHF
1] pulmonary edema or respiratory distress (dyspnea)
2] fatigue
3] renal changes
left sided heart failure
decreased blood to lungs
right sided HF
decreased blood to body
left sided HF
1] dependent edema
2] jugular venous distension
3] abdominal pain (RUQ)
4] cyanosis
right sided HF
CHF for right side is diagnosed by?
liver symptoms, epigastric
major cause of death in 1st year of life
congenital heart defects
obstruction of blood flow to lungs which mixes desaturated and saturatedblood
CYANOTIC
Left to Right shunting of blood in heart through abnormal opening
• Sx can be switched and can present as CHF
acyanotic
Transposition of great vessels
• Tetralogy of Fallot
• Tricuspid atresia
cyanotic congenital heart defects
Ventricular septal defect• Atrial septal defect
• Coarctation of aorta
• Patent ductus arteriosus• Aortic stenosis
acyanotic congenital heart defects
describe transposition of great vessels
pulm artery from L ventricle
aorta from R ventricle
4 defects of Tetralogy of Fallot
have to have all 4
Pulmonary Stenosis
L ventricular septal defect
Aortic communication with both ventricles
R ventricular hypertrophy
tricuspid atresia
everything except right atrium is mixed blood
septal defects- ventricular
between R and L ventricles
- pinhole
septal defects- arterial
between R and L atria
- due to high pressure in L atria
coarctation of aorta
pinched, narrowed aorta
patent ductus arteriosus
connects aorta and pulmonary arteries
symptoms:
Cyanosis • CHF for transposition (newborn) • Tachycardia • Dyspnea • Trouble with feeding • Digitial clubbing
cyanotic
symptoms
- Septal defects- asymptomatic
- Dyspnea
- Trouble with feeding
- Fatigue/exercise intolerance
- Coarctation- HTN
acyanotic
diuretics
decrease plasma volume decrease potassium (kidneys)
ACE inhibitors
lower peripheral resistance
SE chronic cough
renin inhibitors
prevents angiotensin from forming
beta blockers
decrease cholesterol and catecholamines
SE for exercise
angiotensin receptor blockers
reduce angiotensin to vasoconstrict
Ca channel antagonists
relax coronary smooth muscle
vasodilate