CardioVascular Part 2

Question 1

What is the etiology of “diamond skin dz” in pigs

Answer 1

Erysipelothrix rhusiopathiae

Question 2

What do we see on histology for beagle pain syndrome?

Answer 2

Arteritis

Idiopathic necrotizing polyarteritis

Question 3

What do we see on histollogy in pigs with Muberry heart disease

Answer 3

fibrinoid necrosis

Fibrinoid necrotizing arteritis

Question 4

What can we see in swine with edema disease on histology

Answer 4

fibrinoid necrosis

Fibrinoid necrotizing arteritis of the gastric submucosal blood vessels

Question 5

What is verotoxin and what disease is it associated with in pigs?

Answer 5

Edema Disease (enterotoxemic colibacillosis

verotoxin: baceterial enterotoxin

casues endothelial injury in arterioles

           -**fluid loss & edema**

+/- focal bilateral symmetrical encephalomalacia

_(Cerebrospinal angiopathy ) _

Question 6

Artheriosclerosis and its most important pattern?

Answer 6

hardening of the arterioles

• thickening and loss elasticity
• most important pattern is Atherosclerosis

Question 7

How is Athersclerosis characterized?

Answer 7

presence of **atheromas **within the intima and media

atheromatous fibrofatty plaques

-containing cholesterol & lipids

Question 8

T/F: Johne’s disease in cows can cause arterial mineralization(arteriosclerosis) ?

Answer 8

True

the vessels are calcified which we can see grossly PM

Question 9

T/F: Aortic dissection or dissecting a hematoma can result in rupture and fatal hemorrage

Answer 9

True

Question 10

What are causes of arterial ruptures in mares?

Answer 10

** **-physical trauma

• Uterine artery rupture (FATAL)-

         after parturition with **low Cu** serum

-Mycotic vasculitis:** **

** **guttural pouch mycosis can rupture internal carotid artery

-Aortic rupture- rare

           physical excitement / activity (racing, breeding)

            \*also caused in racing greyhounds

Question 11

What deficiency in pigs causes a dissecting aneurysm

Answer 11

_(Cu) _Copper deficency

Question 12

T/F: Aneurysms can lead to ruptures of arteries

Answer 12

True

Question 13

Virchow triad

Answer 13

abnormal blood flow

hypercoagulation

endothelial injury

• trifactor leads to thrombosis

Question 14

What can a signicant loss of antithrombin 3 in a severe renal glomerular disease **(PLN) ** canine cause?

Answer 14

Pulmonary thrombosis

antithrombin 3 is a inhibitor of thrombin

Question 15

What kind of thombosis can we see in Cats with HCM

Answer 15

**Saddle thrombosis **

Question 16

What are some causes of arterial diseases

Answer 16

• Fibrinoid necrosis (​mulberry heart Dz, Edema Dz)
• Arteritis (Erysipelothrix spp., beagle pain syndrome)
• medial calcification (artereosclerosis) (Johne’s dz)
• coronary atherosclerosis

      (hypothyroidism, **BIG** Fucking ** **white veins on heart)

• intimal proliferation
• atrophy
• medial hypertrophy
• dissection aneurysm + rupture

          (hematoma/ **Cu deficiency** in pigs)

• medial hemorrage and necrosis