Cardiovascular Module 2 Part 2 Flashcards
Antihyperlipedemic drugs are also called what
Hmg-coA reductase inhibitor Or Statins
What is the action of statins
Inhibiting the manufacture of cholesterol or promoting the breakdown of cholesterol
Uses of statins
Treatment of hyperlipedemia Primary prevention of coronary events Secondary prevention of cardiovascular events
Adverse reactions of statins
Headache dizziness insomnia Flatulence abdominal pain cramping constipation nausea
Contraindications and precautions for statins
Contraindicated in ppl with hypersensitivity to drug Serious liver disorders During pregnancy and lactation
Statins are what pregnancy category
X
Bile acid resin mechanism of action is what
The bile acid binds resin blinds to bile acids to form an insoluble substance that can not be absorbed by the intestine and secreated in the feces Due to loss of bile acids the liver uses cholesterol to manufacture bile lowering cholesterol levels
Uses for bile acid resins
Hyperlipedemia Pruitis associated with partial billary obstruction
Adverse reactions for bile acid resins
Constipation which may lead to fecal impaction Aggravation of hemorrhoids Abdominal cramps Flatulence Nausea Increased bleeding due to malabsorption of vitamins ADEK
______ may reduce the absorption of vitamins Specifically ADEK
Bile acid resins
Because bile acid resins decrease the absorption of many drugs how should it be administered
Alone And other drugs should be given 1 hour before or 2 hours after
____ can be served in juice or fruit pulp but not carbonated beverages
Bile acid resins
Nanda diagnosis associated with bile acid resins
Altered nutrition less than body requirements
What is the action of fibric acid derivatives
Text synthesis and mobilization of cholesterol
Fibric acid derivatives ____ triglycerides ____ hdl ___ LDL
Decrease Increase Decrease
The adverse reactions of fibrates are associated with what body system
Integumentary Skin rash allopecia etc
Cholesterol Absorption inhibitor inhibit cholesterol absorption from what
Food
What is a common side effect of cholesterol absorption inhibitors
Fatty deposits in school
Nicotonic acid (vitamin b 3) Is similar to what class of drugs
Fibrates
What is a severe side effect of Nicotinic acid
Skin rash
If ____ is taken with food the affects are minimized
Niacin
Another name for an anticoagulant is what
Blood thinner
What is the action of an anticoagulant
Inhibit clot formationPrevent extension of clot Prevent additional clots from forming
______ Will not make existing clots smaller or break them apart
Anticoagulants
What is the drug of choice for acute Thrombolytic conditions
Heparin IV
What is the action of heparin
Interferes with conversion of fibrinogen to fibrin
How is a heparin dose given
First a bolus doses given IV push then infusion and titratedThe dose will be titrated based on the patient’s PTT
What does PTT measure
PTT measures how fast the blood will clot
What should the patient’s PTT Be if they are on heparin
1.5 -2.5 times the control
Heparin subcutaneous must be given where
In the lower abdomen quadrants only
What are two major side effects of heparin
Bleeding and allergies
Why do some people experience allergies. When receiving heparin
Heparin is derived from animal pork and beef
If. Bleeding occurs while on heparin what may you do at the site
Use ice chips and light pressure
What is the antidote for heparin
Protamine or protamine sulfate
What is the drug for low molecular weight heparin
Lovenox
What is the onset and dose for Lovenox
Onset 2-3 hrs Dose 1mg/kg of patients weight usually 70mg
How is low molecular weight heparin different from Heparin subcutaneous
* Prefilled syringe*Don’t expel inject airCheaperNot animalLess bleeding
What is the action of anti-thrombolytic drugs
Inhibit factor X aInhibit conversion of prothrombin into thrombin
The long-term drug of choice for thrombolytic affects is
Warfarin Coumadin
What is the action of Coumadin
Prevent synthesis of vitamin K
What must you teach a patient on Coumadin about their diet
They must have a consistent intake of vitamin K
Although Coumadin dosage is based on the INR what is the average adult dose
2-15mg
What is the antidote for Coumadin
Vitamin k
For patient on Coumadin INR must be between what
3-Feb
If you are planning to administer Coumadin and you check the INR and it is greater than three what would you do
Hold the dose
INr and PT measure what
Ability of blood to clot
The greater the number in the INR the greater the risk of
Bleeding