Cardiovascular Medications Flashcards
Common medications for hypertension
What classes of medications are used in cardiology?
-Angiotensin Converting Enzyme Inhibitors
-Angiotensin Receptor Blockers
-Beta Blockers
-Calcium Channel Blockers
-Diuretics
-Blood Thinners
-Alpha Blockers
-Peripheral Vasodilators
-Nitrites
What do Angiotensin-Converting-Enzyme Inhibitors do
Inhibit an enzyme that activates angiotensin, a hormone that plays a role in regulating blood pressure.
What are indications of ACE-Is?
Hypertension, congestive heart failure, post-myocardial infarction (heart attack) (due to their cardiac-remodeling characteristics)
ACE-Is common suffixes
-pril
Adverse reactions to ACE-Is
ACE-I induced cough, a dry and unproductive cough, angiodema (swelling of the face, throat and tongue), hypotension.
Note: patients who develop this this will need to be switched to another class of medications.
T/F: ACE-Is are contraindicated in pregnancy.
True
Commonlu used ACE-Is
Lisinopril (Zestril; Prinivil)
Benazepril (Lotensin)
Ramipril (Altace)
Enalapril (Vasotec)
Captopril (Capoten)
Quinapril – (Accupril)
What do Angiotensin Receptor Blockers do?
Inhibit the action of angiotensin by blocking the receptors that it normally binds to.
Note: ARBs produce a similar effect to ACE-inhibitors.
What are indications of ARBs?
Same as ACE inhibitors – hypertension, congestive heart failure, post-myocardial infarction (heart attack) (due to their cardiac-remodeling characteristics).
Adverse reactions in ARBs?
dry cough (significantly less so than ACE inhibitors), angioedema, fatigue.
Common ARBs suffix?
-sartan
Common used ARBs
Candesartan (Atacand)
Ibesartan (Avapro)
Losartan (Cozaar)
Olmesartan (Benicar)
Telmisartan (Micardis)
Valsartan (Diovan)
What do antiarrhythmic agents do?
Designed to treat an abnormality of the heart rhythm. They may be used to terminate the abnormal rhythm, prevent it happening or slow the heart rate during the abnormal rhythm to make it more tolerable.
What are indications in antiarrhythmic agents?
Abnormal heart rhythm due to atrial and ventricular fibrillation.
Adverse drug reactions in antiarrhythmic agents?
QT prolongation, dizziness, drowsiness
Commonly used antiarrhythmic agents?
Amiodarone (Cordarone; Pacerone)
Flecainide (Tambacor)
Lidocaine (Xylocaine)
Quinidine (Quinalan)
Propafenone (Rythmol)
What other cardiovascular medications can be used to as antiarrhythmic agents?
Beta blocker and calcium channel blockers
What are indications in anticoagulants/blood thinners?
Prevent the formation of blood cots in blood vessels and reduce the risk of recurrent stroke.
Adverse reactions in blood thinners?
Bleeding, bruising, fatigue
How may bleeding as an ADR present in a patient taking blood thinners?
Signs of bleeding can include nose bleeds, bleeding gums, easy bruising, prolonged bleeding from minor injuries.
Commonly used blood thinners?
Apixaban (Eliquis)
Dabigatran (Pradaxa)
Rivaroxaban (Xarelto)
Warfarin (Janotoven,
Coumadin® – discontinued in 2020)
Enoxaparin (Lovenox)
What blood thinner is taken orally?
Enoxaparin (Lovenox)
What is the antidote to reverse the effects of Warfarin (Coumadin)?
Vitamin K (phytonadione)
Indications in antiplatelet agents?
Prevents platelets from sticking together, which reduces the risk of recurrent myocardial infarction, stroke, or angina.
Adverse reactions in antiplatelet agents?
Bleeding, bruising, stomach irritation
Commonly used antiplatelets?
Aspirin (Various)
Clopidogrel (Plavix)
Ticagrelor (Brilinta)
Prasugrel (Effient)
What are indications in Beta Blockers?
Hypertension, angina (chest pain), myocardial infraction, arrhythmias
Adverse reactions in beta blockers?
Fatigue, bradycardia (slow heart rate), bronchoconstriction, depression
Commonly used Beta Blockers?
Atelol (Tenormin)
Bisoprolol (Zebeta)
Metaprolol Succinate (Toprol XL)
Metaprolol Tartrate (Lopressor)
Carvedilol (Coreg)
Propranolol (Inderal)
Labetalol (Trandate)
Drug-disease interaction with Beta Blockers?
Asthma
Note: Beta Blockers constrict airways
What are indications of Calcium Channel Blockers?
Hypertension, angina, arrhythmias