Cardiovascular Health Lecture 1.2 : Pathogenesis of obesity Flashcards
What kind of condition is obesity?
A low grade inflammatory condition.
What is obesity associated with (name 3)?
Many diseases such as diabetes, cardiovascular and renal diseases.
What kind of agent is leptin?
It is a pro inflammatory cytokine.
Where is leptin produced?
In the GIT, placenta and mammary.
Can leptin cross the blood-brain barrier?
Yes.
By how many folds is leptin increased in obese people?
5 fold increase.
What is the function of leptin?
Maintains hunger and satiety.
(decreases hunger, increases satiety).
Low leptin makes you hungry.
Given leptin’s function, why does are leptin levels so high in obese people?
One would think obese people have low leptin levels, but they are very high becasue they have leptin resistance.
What is a possible cause of leptin resistance in obese people?
Impaired transport across the blood-brain barrier.
What happens to leptin levels after a heart failure or infarct?
They increase.
What is the effect of leptin in obese people like vs a healthy person?
Diminished.
How does leptin exert its effects?
Acts on immune cells, increasing inflammatory cytokine release.
What does effect does leptin have in obese people?
Increases adrenaline and noradrenaline in the blood.
What happens after renal deinnervation in obese subjects?
Hypertension reduction in obese dogs.
What is natriuresis, and what effect does leptin have on it? What effect does it have on blood pressure?
It is sodium excretion, and increased leptin increases it. No effect on blood pressure.
