Cardiovascular Disease and Depression Flashcards
Heads up about this card set
He wanted us to get the main idea, not to get hung up on details. So if this seems not very detailed, its ok.
Relationship b/t CAD and depression
Depresson increases the risk of
coronary artery disease
by 1.5-2.0 times in otherwise physically healthy individuals
The prevalence of depression in cardiovascular populations
Depression is uncommonly common in cardiovascular populations.
Are depressed HF patients at increased risk of death?
Yes and re hospitalization
What physiologic changes are associated with depression?
Autonomic dysfunction Elevated cortisol Platelet activation Endothelial dysfunction Inflammation
Defective serotonin signaling leads to what?
Dysfunction of the amygdala
Dysfunction of the amygdala leads to what?
Autonomic dysfunction & Hypercortisolemia
Depressed pts are less likely to do what?
adhere to medications follow lifestyle recommendations (e.g. quit smoking) practice self-management receive recommended testing follow-up
Depression Tx improves what physiologic markers?
Significant decreases in platelet activation markers
Improved heart rate variability
Reduced inflammatory markers
Normalized brain serotonin turnover
The 2 questions to screen for depression?
- In the past month, have you often been bothered by feeling down, depressed, or hopeless?
- In the past month, have you often been bothered by having little interest or pleasure in doing things?
“YES” to one = 90% sensitive, 70% specific
“NO” to both effectively rules out depression
Depression Tx
-SSRI’s effective, safe, cost-effective
-Bupropion (Wellbutrin)
-Alternative / complimentary strategies:
Cognitive behavior therapy / Problem solving therapy
Exercise training / Cardiac rehabilitation
T or F: B-blockers cause depression
NO!!!
