cardiovascular Flashcards
Functions of the blood
- Transport of gases, nutrients, and waste products.
- Transport of processed molecules
- Transport of regulatory molecules
- Transport of pH and osmosis
- Maintenance of body temperature
- Protection against foreign substances
- Clot formation
What is Plasma?
a yellow fluid that consists of 91% water, 7% proteins, and 2% other components
Albumin
58% in the plasma proteins. The osmotic pressure of blood
Globulins
38% of plasma proteins. Part of the immune system and some are clotting factors
Fibrinogen
Clotting factors that constitutes of 4% plasma proteins
Serum
is a plasma without clotting factor
RBC or erythrocytes
95% of the volume of the formed elements
WBC or leukocytes
5% of the volume of the formed elements. Larger than RBC. Lack of hemoglobin
hematopoiesis
process of blood cell production
All formed elements of blood are derived from a single population of cells
Stem cells or hemocytoblasts
responsible for the cells red color
hemoglobin
Functions of RBC
- transport of oxygen from the lungs to the various tissues of the body
- transport of carbon dioxide from the tissues to the lungs
Give rise to the RBC line
proerythroblasts
Low blood oxygen levels stimulate red blood cell production by increasing the formation and release of the glycoprotein
Erythropoietin
Yellow pigment molecule. Normally taken up by thr liver and released into small intestine
bilirubin
WBC and platelets make up _. A thin white layer of cells between plasma and RBC
buffy coat
WBC can leave the blood and travel by
ameboid movemenet
2 functions of WBC
- protect the body against invading microorganisms and other pathogens
- to remove dead cells and debris from the tissues by phagocytosis
Containing large cytoplasmic granules
Granulocytes
Very small granules that cannot be seen easily
agranulocytes
3 kinds of granulocytes
- neutrophils - most common type of WBC, have small cytoplasmic granules that stain with both acidic and basic dyes.
- basophils - least common of WBC, have large cytoplasmic granules that stain blue. Promote inflammation, prevents the formation of clots.
- eosinophils - cytoplasmic granules ghat stain bright red. Involved in inflammatory responses associated with allergies and asthma.
2 of agranulocytes
- Lymphocytes - smallest of WBC. Body immune response. Production of anti bodies that destroy microoorganisms
- Monocytes- largest of WBC.
Phagocytize bacteria, dead cells, cell fragments, and any other debris within the tissues
Macrophages
Minute fragmemts of cells
Platelets
Large cells
megakaryocytes
immediate but temporary constriction of blood vessel that results when smooth muscle within the wall of vessel contracts
Vascular spasm
Accumulation of platelets that can seal up a small break in a blood vessel
Platelet plug
Platelets stick to the collagen exposed by blood vessel damage
platelet adhesion
Protein produced and secreted by blood vessel endothelial cells
Von Willebrand factor
As platelets become activated, they express surface receptor
Fibrinogen receptors
Fibrinogen forms bridges between the fibrinogen receptors of numerous platelets, resulting in a platelet plug
Platelet aggregation
When a blood vessel is severely damaged, results in the formation of a clot
Blood clotting or coagulation
network of thread like protein fibers
clot
traps blood cells, platelets, and fluid
fibrin
Formation of blood clot depends on a number of proteins within plasma
Clotting factors
analysis of blood that provides much useful information.
CBC
Red Blood Count for male and female
Male - 4.6 - 6.2 million RBC per microliter of blood
Female - 4.2 - 5.4 million RBC per microliter of blood
overabundance of RBC
erythrocytosis
Hemoglobin measurement for male and female
male - 14-18g per 100mL of blood
female - 12-16g per 100 mL of blood
abnormally low hemoglobin measurement. Reduced number of RBC
anemia
percentage of the total blood volume that is composed of RBC
hematocrit
The blood’s ability to clot can be assessed by the platelet count and the prothrombin time measurement
Clotting
Platelet count
250,000 - 400,000 platelets per microliter of blood
platelet count is greatly reduced
thrombocytopenia
calculates how long it takes for the blood to start clotting
Prothrombin time measurement - 9-12 seconds
Composition of materials dissolved or suspended in the plasma can be used to assess the functioning of many of the bodys system
Blood Chemistry
Functions of the heart
- Generating blood pressure
- Routing blood
- Ensuring one way blood flow
- Regulating blood supply
The heart, trachea, esophagus, and associated structures form a midline partition
mediastinum
Located at the base of the heart
Right and Left atria
Extend from the base of the heart toward the apex
Right and left ventricles
Extends around the heart, separating the atria from the ventricles
Coronary Sulcus
Extends inferiorly from the coronary sulcus on the anterior surface of the heart
Anterior interventricular sulcus
Extends inferiorly from the coronary sulcus on the posterior of the heart
Posterior Interventicular Sulcus
Carry blood from the body to the right atrium
Superior and Inferior vena cava
Carry blood from the lungs to the left atrium
Four Pulmonary veins
carry blood to the lungs
Pulmonary arteries
Arising from the right ventricle, carries blood to the rest of the body
Aorta
two atria separated from each other
interatrial septum
two ventricles separated fron each other
interventricular septum
located between right and left atria, and left and right ventricles
Atrioventricular Valves
AV valve between right atrium and left atrium
tricuspid valve
AV valve between the left atrium and left ventricles
bicuspid valve
Each ventricle contains cone shaped, muscular pillars
papillary muscles
Muscles attached by thin, strong, connective strings to the free margins of the cusps of the atrioventricular valves
chordae tendineae
Plate connective tissue, consists mainly of fibrous rings that surround the atrioventricular and semilunar valves and give them solid support
Cardiac skeleton
Supply blood to the wall of the heart
coronary arteries
Originates on the left side of the aorta
left coronary artery
Lies in the anterior interventricular sulcus
anterior interventricular artery
extends around the coronary sulcus on the left to the posterior surface of the heart
circumflex artery
extends inferiorly along the lateral wall of the left ventricle from the circumflex artery
left marginal artery
Originates on the right side of the aorta. Extends around the coronary sulcus kn the right to the posterior surface of the heart
Right Coronary artery
lies in the posterior interventricular sulcus
posterior interventricular artery
Extends inferiorly along the lateral wall of the right ventricle
Right Marginal Artery
Thick, middle layer of the heart. Composed of cardia muscle cells and responsible fkr contraction of the heart chambers
myocardium
Smooth inner surface of the heart chambers. Allow blood to move easily through the heart
Endocardium
Surfaces of the interior walls of the ventricles are modified by ridges and columns of cardiac muscle
trabeculae carneae
Cardiac Muscle cells are bound end to end and laterally to adjacent cells by specialized cell to cell contracts
Intercalated disks
Specialized cell membrane structures in the intercalated disks, allow cytoplasm flow freely between cells
Gap junctions
Contraction of the atria and ventricles is coordinated by specialized cardiac muscle cells in the heart wall
conduction system of the heart
Hearts peacemaker, located in the superior wall of the right atrium and initiates the contraction of the heart
Sinoatrial Node (SA node)
Second area of the heart, located in the lower portion of the right atrium
Atrioventricular node
PA reach the AV node, spread slowly and into bundle of specialized cardiac muscle
Atrioventricular bundle
AV bundle divides into 2 branches of conducting tissue
left and right bundle branches
Tips of the left and right bundle branches, the conducting tissue many small bundles called
purkinje fibers
When AP originate in an area of the heart other than SA node, the result is
ectopic beat
Repetitive pumping process that begins with the onset of cardiac muscle contraction and ends with the beginning of the next contraction
Cardiac Cycle
The contraction of 2 atria
atrial systole
Contraction of 2 ventricles
ventricular systole
Relaxation of 2 atria
Atrial diastole
Relaxation of 2 ventricles
Ventricular diastole
3 main types of blood vessels
arteries, capillaries, and veins
Carry vlood away from the blood, the blood is oxygen rich
Arteries
Exchange occurs between the blood and tissue fluid.
Capillaries
Carry blood toward the heart, the blood is oxygen poor
Veins
Blood vessels walls consists of 3 layers or tunics
- tunica intima
- tunica media
- tunica adventitia
consists of endothelium composed os simple squamous epithelial cells
tunica intima or innermost layer
smooth muscle cells arranged cicularly around the blood vessel. Contains of elastic and collagen fibers
Tunica media or middle layer
dense connective tissue. Becomes loose connective tissue toward the outer portion of the blood vessel wall.
Tunica adventitia
largest diameter arteries and have the thickest walls
Elastic arteries
Medium sized and small arteries
Muscular arteries
Medium sized arteries frequently called _ bc the smooth muscle tissue enables these vessels to control blood flow to diff. body regions
distributing arteries
Contraction of smooth muscle in blood vessels
Vasoconstriction
Relaxation of smooth muscle in the blood vessels
Vasodilation
Trabsport blood from small arteries to capillaries. Smallest arteries in which 3 tunics can be identified
Arterioles
Blood flow through capillaries is regulated by smooth muscle cells
precapillary sphincters
Layer of simple squamous epithelium surrounded by delicate loose connective tissue.
endothelium
Have a diameter slightly larger than that of capillaries
Venules
Allow blood to flow toward the heart but not in the opposite direction
Valves
Slightly larger in diameter then venuels
Small veins
Abnormal heart sounds usually result of faulty valves
murmurs