Cardiomyopathy Flashcards
Diseases of the heart muscle
Classified based on structural and functional abnormalities of the heart
The heart muscle becomes ____,___,or_____
Can lead to _____,_____,or_____
cardiomyopathy
enlarged, thick, or rigid
heart failure, dysrhythmias, or sudden death
cardiomyopathy
pathophysiology
Series of events that lead to –
impaired cardiac output:
-Decreased stroke volume
-Stimulates sympathetic nervous system
-Stimulates Renin-angiotensin-aldosterone response
-Cause increased systemic vascular resistance & increased Na+ and fluid retention
-Causes an increased workload on the heart
Classifications of cardiomyopathies
Non-ischemic:
Dilated cardiomyopathy (DCM)
Restrictive cardiomyopathy (RCM)
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy
Unclassified cardiomyopathies (ex. Takotsubo)
Ischemic:
An enlarged heart caused by ___
Usually accompanied by ___
An enlarged heart caused by CAD
Usually accompanied by HF
Idiopathic cardiomyopathy
the cause is unknown
Presentation
Depends on which type:
if it affects systolic or diastolic function
the age of onset
genetic component
acute vs chronic
Most common
- Dilated cardiomyopathy (DCM)
Dilated cardiomyopathy (DCM)
Most common
Significant dilation of ____
-Without _____
-poor ____ function (EF < 40%)
____ systolic & diastolic volumes in the ventricles
Structural changes cause
-____ blood being ejected
-____ blood remaining in ventricles
-Lead to __
___ dysfunction (_______)
-From an overstretched ventricle
ventricles
hypertrophy
systolic
Elevated
Less
More
HF
Valve
regurgitation
Dilated Cardiomyopathy (DCM):
30-50% linked to _____
_______ screening for all first-degree blood relatives
Early diagnosis & treatment is important in preventing or delaying significant symptoms & sudden death
20-30% are _____
familial genetics
echo & ECG
idiopathic
Dilated Cardiomyopathy (DCM):
Causes:
Pregnancy
Heavy alcohol use
Viral infections
Chemo medications
Persistent tachycardia
HTN
Myxedema (severe hypothyroidism)
Thyrotoxicosis (excess circulating thyroid hormone)
Signs & symptoms of DCM:
Fatigue
Heart murmurs
Shortness of breath (while lying down or during activity)
Edema (in legs, ankles, feet, and neck)
-Sometimes in the abdomen
Chest pain / discomfort
Palpitations, fast fluttering heartbeat
Inability to tolerate exercise
thrombi
Peripartum dilated cardiomyopathy:
Develops within the ___ month of pregnancy – and up to ______ after birth
Treatment:
Little known about it at this time
Can be fatal
-
-
-
-
last
5 months
ACE inhibitors, beta blocker, and diuretics
Shortness of breath when lying flat
Edema
Weight gain
Increase in nighttime urination
fatigue
- Hypertrophic cardiomyopathy
A. Asymmetrical thickening of the hearts ____ or the _____
Systole –
Diastole –
B. Hypertrophied cardiac muscle
Disorganized (______ to one another)
- Decreases effectiveness of contractions – and can increase risk of ________
C. _______ walls thickened
-Decreased diameter – restrict blood flow – ischemia and necrosis – impedes ventricular contraction
left ventricle or the ventricular septum
longer to relax
difficulty filling
Perpendicular
Vfib & Vtach
Coronary arteriole
Hypertrophic cardiomyopathy
A. Autosomal-dominant condition
Most common form of _________
yearly echo from12-18 years of age, then every 5 yrs in susceptible individuals
B. Most common cause for:
-
-
-
-
-
inherited heart disease
Most common cause for sudden cardiac death (SCD) in young competitive athletes
12-lead EKG
Echocardiogram
Physical examinations
Genetic testing for those at risk or suspected
Negative (does not rule out completely)
Positive (1st degree relatives should be tested)
Hypertrophic cardiomyopathy
Main cause of debilitating symptoms in HCM:
Presentation:
LVOT obstruction (Left ventricular outflow tract obstruction)
Breathlessness with activity
Fainting or near fainting
Palpitations
Chest pain with activity
Lightheadedness (with or after exercise/activity)