Cardiomyopathies Flashcards
Pathophysiology of Dilated Cardiomyopathy
The dilated ventricles don’t contract as effectively
More the left ventricle than the right
Investigation of Dilated Cardiomyopathy
Echo - assess the ejection fraction
CXR - dilated ‘balloon’ heart seen
Causes of Dilated Cardiomyopathy (5)
Idiopathic Myocarditis (coxsackie, HIV) Alcohol Cocaine Haemochromatosis
Presentation of Dilated Cardiomyopathy (4)
Fatigue
Dyspnoea
Heart Failure
Systolic Murmur
Management of Dilated Cardiomyopathy (5)
Diuretics ACE-i Anti-coagulants (These are to deal with resultant heart failure) Pacing of ventricles Cardiac transplant
Predominant problem in HOCM
Diastolic dysfunction
Genetics of HOCM
Mutations in the sarcomeric genes (often problems with myosin chains)
Presentation of HOCM (4)
Sudden cardiac death
Heart failure
Syncope
AF
Investigation of HOCM (2)
Echo - needed to diagnose definitively
LVH on ECG
Echo Findings HOCM
Mitral regurgitation
Asymmetric hypertrophy
Management of HOCM (3)
Avoid competitive sport
ICD in high risk patients
B-blockers may be useful
Pathogenesis of Arrhythmogenic Right Ventricular Cardiomyopathy
Fatty replacement of the myocardium and scar tissue
Genetics of Autosomal Dominant ARVC
Stop codon formed in the PKP2 gene
AR ARVC is known as…
Naxos Disease
Presentation of ARVC (4)
Syncope
Breathlessness
Palpitations
Sudden cardiac death