Cardiology Flashcards
Contraindications to exercise stress test
Unstable ACS, HF, arrhythmia, AS, dissection
PE, DVT
Active endocarditis, myopericarditis
Uninterpretable baseline: LBBB, WPW, Paced, digoxin, resting STD>1mm
HOCM/MVP Murmur
- Increases with decreased Preload (stand, Valsalva)
- Decreases with increased preload (squat, leg raise)
- Decreases with increased afterload (hand grip)
MVP longer murmur earlier click with valsalva
AI/MR Murmur
- Decreases with decreased PL (stand, valsalva)
- Increases with increased PL (leg raise, squat)
- Increases with increased AL (hand grip)
AS/MS Murmurs changes w/ maneuvers
- Decreases with decreased PL (stand, valsalva)
- Increases with increased PL (squat, leg raise)
- Decreases with increased AL (hand grip)
Reasons to use Plavix (>Ticag) as 2nd anti-plt
If ACS:
- Patient receiving lytics
- Patient has Afib with CHADS>0 on DOAC
- Patient has high bleed risk (hx intracranial bleed ever, current non-intracranial bleed, mod-sev liver dz)
Post all elective PCI
Indications/Contraindications for tPA in STEMI
- door to needle time
- timing for post-lytic PCI
> 120 mins from nearest PCI center
PCI if >12h or cardiogenic shock
Contraindications
- Bleeding - hemorrhage, ICH ever, stroke <3mo, diathesis, active, anticoag,
- Trauma: head, dissection, recent OR
*Door to needle time should be <=30 mins FMC
Post TPA PCI should occur w/i 24h
Blood thinners post ACS (no Afib or Afib but CHADS 0)
ASA 81 + (Ticag 90 BID or Plavix 75 OD) x 1 yr
After 1 yr:
- If high risk bleed, low thromb risk: ASA alone
- If low risk bleed/high thromb risk: ASA + (Ticag 60 BID or Plavix 75 OD) x 3 years then SAPT
Blood thinners post ACS (Tx PCI) with Afib (CHADS>0)
- ASA 81 + Plavix 75 + DOAC (Apix 5 BID, Dabi 150 BID, Riva 2.5 BID) x 1 day - 1 month –>
- Plavix 75 + DOAC (Apix 5 BID, Dabi 150 BID, Riva 15 OD) x 1 month - 1 year –>
- DOAC Lifelong (Apix 5 BID, Dabi 150 BID, Riva 20 OD)
Blood thinners post ACS (No PCI) with Afib (CHADS >0)
- Plavix 75 + DOAC (Apix 5 BID, Dabi 150 BID, Riva 15 OD) x 1 month - 1 year –>
- DOAC Lifelong (Apix 5 BID, Dabi 150 BID, Riva 20 OD)
Blood thinners post- elective PCI with Afib (CHADS >0)
If high thrombotic risk:
- ASA 81 + Plavix 75 + DOAC (Apix 5 BID, Dabi 150 BID, Riva 2.5 BID) x 1 day - 1 month –>
- Plavix 75 + DOAC (Apix 5 BID, Dabi 150 BID, Riva 15 OD) x 1 mo- 1 year –>
- DOAC Lifelong (Apix 5 BID, Dabi 150 BID, Riva 20 OD)
If low thrombotic risk:
- Plavix 75 + DOAC (Apix 5 BID, Dabi 150 BID, Riva 15 OD) x 1 mo - 1 year –>
- DOAC Lifelong (Apix 5 BID, Dabi 150 BID, Riva 20 OD)
Blood thinners post elective PCI (No Afib or Afib CHADS 0)
If low bleeding risk:
ASA + Plavix 75 x 6 months (extend up to 3 years if high thrombotic risk) –> ASA lifelong
If high bleeding risk:
1. ASA + Plavix x 1 month if BMS / 3 months DES –> ASA
Indications for ICD in HoCM
Prior VT/VF arrest Unexplained syncope Sustained VF >30sec Family Hx SCD LV wall >30 mm NSVT or abN BP response on treadmill w/ other risk factors
HFrEF (EF <40%): Medical Treatment
1st line: ARNI ACE/ARB, BB, MRA (ISDN/Nitro if intol to ACE/ARB), SGLT2
- Add Ivabridine (if SR >70, ie NOT afib, not paced, hosp for HF in last year)
- Vericiguat if recent HF hospitalization
- Digoxin if poor AF control
If going NYHA 4 symptoms –> palliative care, add ISDN/Nitro, adv HF therapy
HFrEF: Indications for primary prevention ICD +/- CRT
EF <=35% after 3 mo post-revasc/OMT/40d post- MI:
- NYHA 1: ICD ONLY IF ischemic CM + EF <=30%
- NYHA 2-3: ICD +/- CRT* (*if sinus rhythm, + LBBB >130 msec, or any BBB >150 msec)
- NYHA 4: ICD +/- CRT* (only if ambulatory, expected to improve, or candidate for adv tx)
- expected life expectancy >1y and reasonable QoL
- weak rec: CRT in frail elderly, permanent AF, chronic RV pacing + symptomatic HFrEF
HFeEF: Indications for secondary prev ICD
VT/VF Arrest or Sustained VT (>=30 secs or hemodynamically significant) with structural heart disease or >48 hrs post MI /revasc
No reversible cause found
HFpEF: Medical Treatment
Manage HTN (ACE/ARB = 1st line) Diuretics for symptoms MRA if elevated BNP Consider candesartan **no recommendation for ARNI
-empa ?mort benefit
Diagnosis Pericarditis
2/4 of:
1) Typical CP (pleuritic, worse when supine)
2) Pericardial Rub
3) ECG: Diffuse STE +/- PR depression w/o reciprocal ST depression
4) New or worsening pericardial effusion on echo
Tx Pericarditis (1st, recurrent, pregnancy)
1st episode: NSAID x2weeks + Colchicine x 3 months
Recurrence: NSAID x2weeks + colchicine x6 months
Post MI: High dose ASA (650mg QID) + Colchicine
AI or refractory NSAID: Pred + Colchicine
Pregnancy: No ASA, NSAID, Colchicine.
Breastfeeding: No ASA
Advanced: IVIG, anakinra, azathioprine, pericardioectomy
Tx Thoracic Aortic Dissection
Type A - Surgical
Type B (does not involve ascending aorta) - IV labetalol (target HR <60-65, sBP <120), IV nitroprusside if BP refractory to labetalol, consult vascular surg
(can also use CCB or ACEi)
When to operate: Thoracic Ao aneurysm
*how often to screen
5.5 cm - degenerative/bicuspid valve
5 cm - Marfan’s, rapid growth
4.5 cm - all other congenital disorders (turner, ehlers-danlos, etc)
*F/U: q6-12mo (dep on rate of change), q6m if genetic aortopathy; MRI if <50yo bc serial radiation
When to operate: AAA
*how often f/u
5.5 cm for all
5 cm if: Female, +FHX, Hx CTD, Rapid growth >0.5 cm/year
*F/U: q6-12 mon if <4.5 cm, q3-6 mo >4.5 cm
Monitoring Bicuspid AoV
Annual H&P
Repeat echo only if evidence of stenosis, aortic dilatation or new symptoms
- If stenosis: q3-5years mild, q1-2 years moderate, q6-12 mo if severe and not candidate for replacement
- If aortic root dilation: q6-12 mo
AS: Indications for valve replacement
1) Severe Symptomatic AS (AVA <1cm, MG >40mmHg, peak veloc >4m/s) (D1)
2) Severe AS w/ LVEF <50% (C2)
3) Symptomatic Low-flow low-gradient AS (AVA <1cm, MG <40/V <4, LVEF <50%) with symptoms if MG>40/V>4 with dobutamine stress test (D2)
4) Symptomatic Low-flow low-grad AS with EF<50% OR if AS most likely cause of sx
5) Severe AS without symptoms if symptoms develop on exercise stress (C1)
6) Sevee AS without symptoms going for other CV surgery
AI: Indications for valve repair/replacement
1) Severe Symptomatic AI
2) Severe AI with LVEF <55% if no other cause for reduced LVEF
3) Severe asymptomatic AI going for other CV Surgery
Rheumatic MS: Indications for valve repair/replacement
Percutaneous Mitral balloon Commisurotomy (PBMC): Severe MS (dw: MVA <=1.5 cm, PAP >50, dBP 1/2t >=150) + NYHA 3-4 + no contraindications (>= mod MR, LA thrombus) + fav anatomy
MV surgery (commisurotomy +/- repair/replacement):
- Failed or contraindication for PBMC + acceptable surgical risk
- Severe MS going for other CV surgery
MS: Indications for anticoagulation and targets
- Afib
- TIA/Stroke
- LA Thrombus
VKA –> Target INR 2.5-3.5
MR (primary): Indications for MVR
- Severe primary symptomatic MR
- Severe primary asympatomatic MR with LVEF <60% or LVESD >=40mm Hg
For secondary: must be on OMT, including CRT & revascularization
TR: Indications for TVR
Severe TR going for other left sided valve surgery
Anti-coagulation post valve-replacement
mech vs bioprosthetic targets and agent
Mechanical = Lifelong VKA
- Modern AVR - INR 2-3
- Mitral or ball in cage AVR - INR 2.5-3.5
Bioprosthetic
First 3-6mo: Surgical: VKA (INR 2-3) + ASA;
vs/ TAVR: DAPT (Plavix) or VKA (INR 2-3) +ASA
- Then ASA for life
A.fib: Who gets anticoagulation, exclusion, and when to use VKA
- > = 65
- <65, but 1 of: CHADS (CHF, HTN, DM, Stroke
- Mitral stenosis
* *Exclusion: No anticoagulation for ESRD with eGFR <15
VKA: if mechanical valve, rheumatic MS, mod/severe non rheumatic MS
DOAC Doses for Afib
- Apix 5 BID (2.5 BID if 2 of: Age>=80, Cr >=133, Wt <60kg) - ok till eGFR 15
- Rivaroxaban 20 OD (15 OD if CrCl <50) - ok till eGFR 15
- Dabi 150 BID (110 BID if CrCl <50 or age >75) - ok till eGFR 30
- Edoxaban 60 OD (30 OD if CrCl <50 or weight <60kg) - ok till eGFR 30
* See other CAD slides for doses if being combined with anti-plt
Afib: Who gets immediate cardioversion
Electrical cardioversion (w 4 weeks AC post) if:
1) Hemodynamically unstable
2) NVAF <12 hrs and no prior stroke
3) NVAF 12-48 hrs and CHADS2 0-1 (age >75 not 65 as per CHADS65)
*All others, start rate control and 3 weeks of anticoagulation and reassess for cardioversion as outpatient
Persistent Afib: Who gets rhythm control > rate and how?
Who:
- Afib <1 year
- High symptom burden/QoL impact
- Multiple recurrence or difficulty achieving rate control
- CHF secondary to afib
How:
- Anticoagulate x 3 weeks (unless meeting criteria for immed cardioversion)
- Electrical or chemical cardioversion
- Initiate maintenance anti-arrhythmic if Sx improve with cardioversion
Paroxysmal Afib: Treatment Algorithm
Low Symptom burden: Observe vs pill in pocket
High symptom burden: Maintenance anti-arrhythmic +/- catheter ablation