Cardiology Flashcards
What is angina?
Chest pain on exertion caused by myocardial ischaemia from coronary heart disease, usually atherothrombosis
What is the difference between stable and unstable angina?
Stable angina is induced by effort and relieved by rest/GTN spray
Unstable angina is an acute coronary syndrome with pain at rest/not relieved by GTN
List aetiology/risk factors for angina
Atherosclerosis Males Smoking, excess alcohol Poor diet, obesity Arteritis Low exercise Hypertension Diabetes
List clinical features of angina
Central chest tightness on exertion Pain may radiate to jaw/arm Dyspnoea Nausea Sweating Syncope
What investigations would you order for angina?
ECG may be normal
Exercise ECG, 24h ECG
CT catheter angiography
Outline medical treatment for angina
GTN spray when required
Secondary prevention (aspirin, statin, ACEi)
B-blockers unless contraindicated
Ivabradine/nicorandil if others not tolerated
Outline surgical treatment for angina
Coronary revascularisation (PCI, CABG) using balloon stent or graft bypass from internal mammary artery and greater saphenous vein
What are the acute coronary syndromes (ACS)?
Unstable angina
NSTEMI
STEMI
What is the pathophysiology of ACS?
Atherothrombotic plaque rupture leads to thrombosis and complete occlusion of coronary artery, causing ischaemia and potential necrosis
List risk factors/aetiology for ACS
Males Family history Smoking, excess alcohol Hypertension Diabetes High cholesterol Obesity Sedentary lifestyle
List clinical features of ACS
New onset severe crushing chest pain, radiating to arm and/or jaw Nausea, vomiting Not relieve by rest or GTN Breathlessness Syncope Confusion Pallor, sweating Palpitations, tachycardia SENSE OF IMPENDING DOOM
What investigations would you do for ACS?
Bloods: cardiac enzymes (CK, troponin), electrolytes, glucose, lipids
ECG
CXR
What is the criteria for STEMI on ECG?
ST elevation of 1mm or more in 2 adjacent limb leads
or
ST elevation of 2mm or more in 2 contiguous chest leads
List ischaemic changes on ECG
T wave inversion Q waves Tall T waves ST depression ST elevation
When do levels of troponin and CK peak in ACS?
Troponin: 3-12 h
CK: 24 h
Outline medical treatment for acute MI
Aspirin 300 mg
GTN sublingual
IV morphine
O2 if hypoxic
Outline definitive treatment for acute NSTEMI
B-blocker IV
LMW heparin
IV nitrate
Angiography if high risk
Outline definitive treatment for acute STEMI
PCI within 120 mins
Otherwise thrombolysis with streptokinase + aspirin, then reassess after 90 mins for need for PCI
What are the different stages of hypertension? (stage 1, stage 2 etc.)
Stage 1: 140-159/90-99
Stage 2: 160-179/100-109
Stage 3: 180/110 or higher
List risk factors/aetiology for hypertension
Renal disease (GN, polyarteritis, renal artery stenosis)
Endocrine disease (Cushing’s, Conn’s, phaeochromocytoma)
Pregnancy
Drugs
Alcohol excess
High salt intake
Essential hypertension (idiopathic)
List clinical features of hypertension
Asymptomatic Headache Palpitations Breathlessness Advanced disease: blurred vision, palpable kidney, RF delay
What investigations would you do for hypertension?
ECG, echo Bloods: electrolytes, endocrine markers Funduscopy Urinalysis Home/ambulatory BP monitoring
How is hypertensive retinopathy graded?
I: tortuous arteries, narrowing/sclerosis
II: AV nipping, marked sclerosis
III: haemorrhages, cotton wool spots, hard exudates
IV: III + papilloedema
Outline medical management of hypertension
If under 55yo, start with ACEi If over 55yo or black, start with Ca ch blocker If uncontrolled on these, ACEi + Ca ch blocker then add thiazide diuretic then add alpha/beta blocker