Cardiology Flashcards
Define atherosclerosis
Combination of atheroma’s - fatty deposits - and sclerosis - hardening or stiffening - affecting medium to large arteries, caused by chronic inflammation leading to deposition of lipids and formation of plaques.
Risk factors for atherosclerosis
Age
FH
Male
Smoking
Alcohol
High sugar and fat diet low fruit and veg
Low exercise
Obesity
Poor sleep stress
Diabetes
HTN
CKD
Rheumatoid
Atypical antipsychotics
Complications of atherosclerosis
Angina
MI
TIA
Stroke
Peripheral vascular disease
Mesenteric ischaemia
Prevention of CVD
Diet, exercise and weight improvement
Stop smoking
Stop drinking
Tightly treat co-morbidities
Score the determine risk of stroke or MI in next 10 years
QRISK3 - if >10% risk, offer statin
Secondary prevention of CVD
AAAA
Aspirin
Atorvastatin
Atenolol
ACE inhibitor
Define stable angina
Narrowing of the coronary arteries such that during time of high demand, exercise, insufficient blood supply to the hear causing chest pain. Stable when symptoms are relieved by rest or GTN.
Investigations in stable angina
CT coronary angiogram - gold standard diagnostic
Physical examination
ECG
Bloods - FBC, UE, LFT, Lipid, Thyroid, HbA1c
Management of stable angina
RAMP
Refer to cardiology
Advise about diagnosis management and when to phone ambulance
Medical treatment
Procedural or surgical interventions
GTN - every 5 mins
Beta blockers, CCBs are first line
Long acting nitrites, ivabradine, nicorandil, ranolazine
2dry prevention - AAAA
Surgery - PCI, stents, balloon dilation, CABG
Define acute coronary syndrome
Term used to describe a range of conditions associated with sudden reduced blood flow to the hear.
Main types of ACS
Unstable angina
STEMI
NSTEMI
What is supplied by the Right Coronary artery
Inferior aspect
Right atrium
Right ventricle
Inferior aspect of left ventricle
Posterior aspect of septal area
What is supplied by the circumflex artery
Lateral aspect
Left atrium
Posterior aspect of the left ventricle
What is supplied by the Left anterior descending
Anterior aspect
Anterior aspect of the left ventricle
Anterior aspect of the septum
How to differentiated types of ACS
Chest pain = ECG
ST elevation - STEMI
No elevation = troponin
Raised trops +- other ECG changes - NSTEMI
Trops normal - unstable angina (or msk pain)
History of ACS
Central crushing chest pain
Nausea and vomiting
Sweating and clamminess
Feeling of impending doom
Shortness of breath
Palpitations
Pain radiates to jaw/arm
Symptoms continue at rest
Diabetic often have silent MIs - no pain
ECG changes in STEMI
ST segment elevation
New left bundle branch block
ECG changes in NSTEMI
ST depression
Deep T wave inversion
Pathological Q waves
Alternative causes for raised troponins
Chronic renal failure
Sepsis
Myocarditis
Aortic dissection
Pulmonary embolism
Investigations in ACS
Physical exam
ECG
Bloods - FBC, UE, LFT, Lipid, Thyroid, HbA1C
CXR
Echo - post event
CT coronary angiogram
Immediate management of ACS
MONA
Morphine
Oxygen (if low sats)
Aspirin 300mg
Nitrates - GTN
Management of STEMI
Primary PCI - if available within 2 hours
Thrombolysis - in PCI not available
Management of NSTEMI
BATMAN
Betablockers
Aspirin 300mg
Ticagrelor 180mg stat
Morphine
Anticoagulation - fodaparinux
Nitrates GTN
Complications of MI
Heart failure DREAD
Death
Rupture of heart septum or papillary muscles
Edema - heart failure
Arrhythmia + Aneurysm
Dressler’s Syndrome