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Cardiology Flashcards

1
Q

What is the pathophysiology of Acute Coronary Syndrome? (4)

A

It is the accumulation of Low Density Lipoproteins

Leukocytes attach onto the vascular endothelium and gain entry into the intima where they form Foam Cells

The remodelling of arteries and calcification, with Foam Cells causes Atherosclerotic Plaques

Plaque Rupture causes Platelet Activation and Occlusion

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2
Q

What are the 2 types of Myocardial Infarction and what causes them?

A

Type 1 Myocardial Infarction- due to an Atheromatous Plaque Rupture

Type 2 Myocardial Infarction- which occurs secondary to Ischaemia due to an Increase in Oxygen Demand or Decrease in Oxygen Supply due to (3)-

  • Anaemia
  • Sepsis
  • Vasospasm

(In Type 2, you would treat the underlying cause as well)

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3
Q

What kind of Murmur is typically heard in Myocardial Infarction?

A

A Systolic Murmur- Mitral Regurgitation or Ventricular-Septal Defect

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4
Q

What are the symptoms of Acute Coronary Syndrome? (4)

A

Sweating

Anxiety

Nausea/ Vomiting

Central Chest pain which may radiate to the Left Arm and Neck

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5
Q

What 5 investigations should be ordered if Acute Coronary Syndrome is suspected?

A

Coronary Angiogram- Diagnostic

Perform ECG within 10 minutes

Measure Troponin levels- elevated in STEMI and NSTEMI but not in Unstable Angina

Perform a CXR if needed, to eliminate other potential causes

Work out their GRACE Score

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6
Q

What is the management for Unstable Angina/ NSTEMI? (5)

A

MONA B

  • Morphine
  • Oxygen (if<94%)
  • Nitrates
  • Aspirin
  • Beta Blockers

DAPT (2)-

  • Aspirin and Clopidogrel
  • Aspirin and Prasugrel if Patient is gonna have PCI

Anticoagulation (2)-

  • Unfractionated Heparin- if Coronary Angiography is planned or if Creatinine>265
  • Fondaparinux- otherwise

If their GRACE Score is 89 or above AND they have an Unstable Angina or NSTEMI, then offer Immediate Angiogram and PCI

PCI should be performed within 120 minutes of Symptom Onset, otherwise offer Thrombolysis with (3) Alteplase, Tenecteplase and Streptokinase and offer Low-Molecular Weight Heparin unless (5)

  • Haemorrhage
  • Stroke, Head Trauma, Neurosurgery within the last 3 months
  • Internal Bleeding
  • Endocarditis
  • Aortic Dissection
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7
Q

What is the management for STEMI? (5)

A

(Same as Unstable Angina/ NSTEMI but give Bivalirudin with Aspirin and not Prasugrel with Aspirin if a PCI is being performed)

MONA B

  • Morphine
  • Oxygen (if<94%)
  • Nitrates
  • Aspirin
  • Beta Blockers

DAPT (2)-

  • Aspirin and Clopidogrel
  • Aspirin and Bivalirudin if Patient is gonna have PCI

Anticoagulation (2)-

  • Unfractionated Heparin- if Coronary Angiography is planned or if Creatinine>265
  • Fondaparinux- otherwise

If their GRACE Score is 89 or above AND they have an Unstable Angina or NSTEMI, then offer Immediate Angiogram and PCI

PCI should be performed within 120 minutes of Symptom Onset, otherwise offer Thrombolysis with (3) Alteplase, Tenecteplase and Streptokinase and offer Low-Molecular Weight Heparin unless (5)

  • Haemorrhage
  • Stroke, Head Trauma, Neurosurgery within the last 3 months
  • Internal Bleeding
  • Endocarditis
  • Aortic Dissection
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8
Q

What are the 6 early complications and 2 late complications (after 2 weeks) of Acute Coronary Syndrome?

A

Early-

  • Post MI Pericarditis
  • Cardiac Arrest, most likely due to Ventricular Fibrillation
  • Bradyarrhythmias- Heart Block is common after Inferior MI
  • Cardiogenic Shock
  • Ventricular Septal Defect/ Mitral Regurgitation
  • Left Ventricular Wall Rupture- Ischaemia leads to a weakened ventricular wall and rupture which presents as a Cardiac Tamponade and Acute Heart Failure

Late Complications-

  • Dressler’s Syndrome (An Autoimmune version of Pericarditis)
  • Left Ventricular Aneurysm
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9
Q

What are the 2 common causes of Acute Decompensated Heart Failure?

A

Coronary Artery Disease

Hypertension

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10
Q

What is the pathophysiology of Acute Decompensated Heart Failure? (5)

A

The reduced cardiac output activates the Sympathetic Nervous System

This results in Tachycardia and an increased Myocardial Contractility, Peripheral Vasoconstriction and RAAS Activation- Salt and Water retention

Heart Failure patients are Hypovolaemic do BNP is released by Ventricular Myocytes due to stretch

This leads to Pulmonary and Venous Congestion

This leads to a Pulmonary Oedema (look out for shortness of breath)

This can also lead to a Peripheral Oedema due to Venous Congestion

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11
Q

What are the 6 signs of Acute Decompensated Heart Failure? What are the 3 signs of Congestive Heart Failure?

A

Coarse Bibasal Crackles

S3 heard

Stony Dull Percussion if Effusion is present

Dyspnoea due to Pulmonary Oedema (patient often has a history of Orthopnoea and Paroxysmal Nocturnal Dyspnoea)

Cardiogenic Wheeze

A reduced Left Ventricular Ejection Fraction (<40%)

Congestive Heart Failure (3)

  • Pitting Oedema
  • Peripheral Oedema
  • Raised JVP
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12
Q

What is the 5 step management for Heart Failure? (3 for immediate and 2 for long-term)

A
  • Oxygen if <94%
  • Fluid Restriction
  • An IV Diuretic- Loop Diuretic usually- like Furosemide

Long Term Treatment-

  • ACE Inhibitor and Beta Blocker (Ramipril and Bisoprolol)- if Left Ventricular Ejection Fraction< 40%
  • Loop Diuretic for Symptomatic Treatment of Oedema)
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13
Q

What is the pathophysiology of Pericarditis?

A

The pericardium is innervated by the Phrenic Nerve

It is the Inflammation of the Pericardium commonly caused by the COXSACKIE VIRUS

It may produce a Pericardial Effusion which develops into Cardiac Tamponade

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14
Q

What are the 5 other causes of Pericarditis? Aside from Coxsackievirus

A

TB

Systemic Autoimmune Diseases

Uraemia- secondary to Kidney Disease

Post-MI

Hypothyroidism

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15
Q

Where is the Pericardial Rub (sign of Pericarditis) heard?

A

It is heard at the Left Sternal Edge when the patient leans forward. It is High-pitched and Squeaky

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16
Q

What are the 4 symptoms of Pericarditis?

A

A sharp central chest pain which gets worse when the patient breathes in or lies down

Fever may also be present

Tachypnoea and Tachycardia

A Peripheral Oedema suggests a Right Sided Heart Failure secondary to Pericarditis

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17
Q

What 3 investigations should be ordered if Pericarditis is suspected?

A

Urea- High Urea suggests a Uraemic Cause

Transthoracic Echocardiogram and CXR to exclude Pericardial Effusion/ Cardiac Tamponade

ECG- PR Depression and ST Elevation

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18
Q

What is the management of Idiopathic/ Viral (2) Pericarditis and Bacterial (1) Pericarditis?

A

Idiopathic/ Viral Pericarditis

  • NSAIDs and Colchicine
  • NSAIDs, Colchicine and a low dose Prednisolone

Bacterial Pericarditis

  • IV Antibiotics and Pericardiocentesis

Look out for evidence of Cardiac Tamponade (a Raised JVP/ Hypotension)- Perform Pericardiocentesis if suspected

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19
Q

What infection would make Constrictive Pericarditis likely?

A

TB

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20
Q

What is the pathophysiology of Angina Pectoris?

A

It is an imbalance in the Oxygen Supply and Demand which leads to Ischaemia

The Monocytes scavenge lipid deposits and transform into Foam Cells

Cytokines are released by Foam Cells which promotes SMC migration into the Intima from the Arteria Media

Could also be Non-Atheromatous due to Coronary Artery Vasospasm (Prinzmetal’s Angina)

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21
Q

What are the 7 signs of Angina Pectoris?

A

Central chest pain caused on exertion

Dyspnoea

Nausea

Sweating

S3 Heart Sound

Carotid Bruit/ Expansile Abdominal Aorta- suggests Peripheral Vascular Disease which increases the likelihood of Coronary Atherosclerosis

Hypertension

Xanthomata/ Xanthelasma- Hypercholesterolaemia

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22
Q

What investigations should be ordered in Angina Pectoris is suspected?

A

ECG

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23
Q

What is the management for Angina Pectoris?

A

GTN Spray for Symptomatic Relief

Antianginal Medication-

  • Betablocker or non-dihydro Calcium channel blocker
  • Betablocker and dihydro Calcium channel blocker
  • Nitrates- patient can grow tolerant

Revascularisation-

  • Percutaneous Intervention
  • Coronary Artery Bypass Graft
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24
Q

What type of Tachycardia is Atrial Fibrillation?

A

Supraventricular Tachycardia

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25
Q

What are the causes of Atrial Fibrillation?

A

PIRATES

Pulmonary (PE and COPD)
Ischaemic Heart Disease- Including heart failure
Rheumatic Heart Disease- any valvular abnormality
Anaemia/ Alcohol/ Advancing Age
Thyroid Disease (Hyperthyroidism)
Electrolyte Disturbance- Hypo/Hyperkalaemia and Hypomagnesaemia
Sepsis and Sleep apnoea

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26
Q

What are the 4 red flag symptoms associated with Atrial Fibrillation and should be looked into further if present in AF?

A

Chest Pain

Syncope

Hypotension- suggests haemodynamic instability

Evidence of Heart Failure- Pulmonary Oedema

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27
Q

What 5 investigations should be ordered if Atrial Fibrillation is suspected?

A

ECG

TFTs- to check for Hyperthyroidism

Troponin- if MI is suspected

Transthoracic Echocardiogram- if an underlying Structural or Functional Heart Disease is suspected

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28
Q

What 4 Adverse Effects would suggest DC Cardioversion is needed in Atrial Fibrillation or Bradycardia?

A

Shock- Hypotension, Pallor, Sweating, Cold Clammy Extremities, Confusion or Impaired Consciousness

Syncope- Transient Loss of Consciousness

MI- Typical Ischaemic Chest pain or Evidence of MI on ECG

Heart Failure- if Pulmonary Oedema or Raised JVP

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29
Q

What is the management of Atrial Fibrillation?

A

If adverse effects are present- DC Cardioversion then Rhythm Control

Rate Control (3)

  • Beta Blocker or Calcium Channel Blocker (same as first line for Angina)
  • Add Digoxin if there is Atrial Fibrillation and Heart Failure
  • Add Digoxin to either Bisoprolol or Diltiazem

Rhythm Control (2)

  • Flecainide or Amiodarone (if there is no evidence of an Ischaemic or Structural Heart Disease)
  • Otherwise Amiodarone

For Anticoagulation (3)

  • DOAC
  • Warfarin
  • Heparin
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30
Q

What Heart Rate defines Bradycardia?

A

A Heart Rate lower than 50bpm

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31
Q

What is a Heart Block?

A

It is a disrupted passage of electrical impulse through the AV Node

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32
Q

What is a First Degree Heart Block?

A

It consists of a Prolonged PR Interval with No Missed Beats

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33
Q

What is a Second Degree Mobitz 1 Heart Block?

A

The PR Interval becomes longer and longer until a QRS Complex is missed, the pattern then resets

This is known as the Wenckebach Phenomenon

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34
Q

What is a Second Degree Mobitz 2 Heart Block?

A

Prolonged PR Intervals with thee QRS Complex becoming regularly missed

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35
Q

What are the 5 causes of First and Second Degree Heart Blocks?

A 
Physical Fitness
Drugs (Digoxin and Beta Blockers)
Sick Sinus Syndrome
Acute Myocarditis
Ischaemic Heart Disease (especially Inferior Myocardial Infarction)
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36
Q

What is a Third Degree (Complete) Heart Block?

A

No impulses are passed from the atria to the ventricles so the P waves and QRS complexes are independent of each other

The Tissues distal to the AVN paces slowly as a result and the patient becomes Bradycardic

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37
Q

What are the 7 causes of a Complete Heart Block?

A 
Idiopathic (Fibrosis)
Congenital
Aortic Valve Calcification
Cardiac Surgery/ Trauma
Ischaemic Heart Disease
Digoxin Toxicity
Infiltration (Abscess, Granulomas, Tumours, Parasites)
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38
Q

What are the 4 risk factors for Bradycardia?

A

Infections
Hypothyroidism
Hypo/Hyperkalaemia, Hypo/Hypercalcaemia
Hypothermia

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39
Q

What is the Cushing’s Triad for a Raised ICP?

A

Bradycardia
Hypertension
Irregular Respiration (Apnoea)

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40
Q

What are the Cannon A Waves seen in the JVP?

A

They are a sign of Complete Heart Block due to atrial contraction against a closed Tricuspid Valve

41
Q

What 5 investigations should be ordered in a patient with Bradycardia?

A

ECG
TFTs- to check for Hypothyroidism
U and Es and metabolic panel- to check for Electrolyte Changes
Serum Digoxin Levels- check in patients who take Digoxin
ECHO- if LVEF<30 give them a Pacemaker

42
Q

What is the management for Bradycardia? (4)

A

Atropine

Adrenaline, Isoprenaline and Aminophylline if Atropine does not work or if the patient has Heart Block

43
Q

What 14 things can cause an Increased BNP level? (6 Cardiac Causes, 3 Respiratory Causes, 5 other causes)

A 
Left Ventricular Hypertrophy
Right Ventricular Overload
Diastolic Dysfunction
Atrial Fibrillation
Acute Coronary Syndrome
Valvular Heart Disease

Acute Pulmonary Embolism
Pulmonary Hypertension
COPD with Cor Pulmonale

Hyperthyroidism (causes Atrial Fibrillation)
Sepsis
Acute or Chronic Kidney Injury

Diabetes
Age>70

44
Q

What can cause a Decreased BNP level?

A

Cardiac Drugs

45
Q

What is the pathophysiology of a Cardiac Tamponade?

A

There is a reduction in the cardiac output due to a Raised Intrapericardial Pressure, secondary to Pericardial Effusion

It squeezes the heart chambers and reduces the Stroke Volume and Cardiac Output

46
Q

What are the 6 causes of a Cardiac Tamponade?

A 
Pericarditis (due to Infectious/ Uraemic reasons)
Surgery
Malignancy
Trauma
Aortic Dissection
SLE/ Rheumatoid Arthritis
47
Q

What are the 9 signs of a Cardiac Tamponade?

A

Dyspnoea

Chest Discomfort

Tachycardia

Peripheral Oedema (Heart Failure)

Pulsus Paradoxus (Systolic Blood Pressure reduced by over 10mmHg upon Inspiration)

Confusion due to a Decreased CNS Perfusion

Prolonged Capillary Refill Time

Cool Peripheries

Beck’s Triad (3)

  • Hypotension
  • Raised JVP
  • Muffled Heart Sounds
48
Q

What does the ECG look like for a Cardiac Tamponade?

A

There are alterations in the Amplitude of the QRS Complex

49
Q

What 5 investigations should be ordered if Cardiac Tamponade is suspected?

A

Transthoracic Echocardiogram

ECG

Inflammatory Markers- suggest Pericarditis is the cause

Troponin- suggests MI is the cause

CXR- raised Cardiac Silhouette

50
Q

What is the management of Cardiac Tamponade?

A

Pericardial Effusion with No Evidence of Tamponade-
- NSAIDs or Colchicine if the suspected Underlying Cause is Pericarditis

Pericardial Effusion with Evidence of Tamponade

  • Pericardiocentesis
  • Surgical Drainage if Blood or Pus is present
51
Q

What are the 2 main complications of Cardiac Tamponade?

A

Cardiac Arrest (increased Intrapericardial Pressure may lead to a significantly reduced Cardiac Output and Cardiac Arrest)

Constrictive Pericarditis- which is likely in Tuberculosis

52
Q

What is the pathophysiology of Congestive Heart Failure?

A

In normal physiology, an increased ventricular filling would result in an increased contraction and increased cardiac output

This mechanism fails in Congestive Heart Failure and compensatory mechanisms are activated- including an Increased Heart Rate, Catecholamine Release and activation of the RAAS. When these compensatory mechanisms are overexpressed, it can lead to a VICIOUS CYCLE

As both the Right and Left Hearts are affected, both Pulmonary and Peripheral Oedemas are present

53
Q

What are the 7 signs of a Left-sided Heart Failure?

A

Dyspnoea

Orthopnoea/ Paroxysmal Nocturnal Dyspnoea

Cough with Pink Frothy Sputum

Peripheral or Central Cyanosis

Displaced Apex Beat

Coarse Bibasal Crackles

S3 Sound

54
Q

What are the 7 signs of a Right-sided Heart Failure?

A

Swelling in legs

Raised JVP

Distended Abdomen

Fatigue and Weakness

Hepatosplenomegaly

Ascites

Peripheral Pitting Oedema

55
Q

What is seen in the ECG of a Congestive Heart Failure patient?

A

a Broad QRS Complex with Left Ventricular Hypertrophy

56
Q

What are the 6 steps in the management of Congestive Heart Failure, and 3 other considerations?

A

First Line- Beta Blockers and ACE Inhibitors
- Bisoprolol, Carvedilol and Nebivolol

Beta Blockers and ACE Inhibitors do NOT improve mortality in Heart Failure with a Preserved Ejection Fraction

Second Line- Aldosterone Antagonists (Spironolactone)

Third Line- Cardiac Resynchronisation Therapy/ ICD Defibrillator
- If QRS>120 and LVEF<35%

Digoxin- if the patient has Atrial Fibrillation and Heart Failure

Ivabradine if the Heart Rate is higher than 75 and LVEF<35% and the patient is already on suitable medication

Other Considerations (3)-

  • Fluid Restriction
  • Loop Diuretics (for Symptomatic Relief)
  • Avoid Calcium Channel Blockers in Heart Failure Patients with a reduced LVEF
57
Q

What are the 3 complications of Congestive Heart Failure?

A

Pleural Effusion

Acute Decompensation of Chronic Heart Failure (patients present with Acute Respiratory Distress Syndrome due to a significant Pulmonary Oedema)

Acute Renal Failure- due to reduced Cardiac Output and Drug Overdose

58
Q

What is the blood pressure range for Hypertension?

A

a Blood Pressure higher than 140/90 (or 135/85 for Ambulatory)

59
Q

What are the Renal (4), Endocrine (5), Medication (4) and Other (1) causes of Hypertension?

A

Renal-

  • Renal Artery Stenosis
  • Polycystic Kidney Disease
  • Chronic Kidney Disease
  • Glomerulonephritis

Endocrine-

  • Primary Hyperaldosteronism
  • Phaeochromocytoma
  • Cushing’s
  • Hyperthyroidism
  • Acromegaly

Medication-

  • Glucocortoids
  • Ciclosporin
  • Atypical Antipsychotics
  • Combined Oral Contraceptive Pills

Other-
- Pregnancy

60
Q

What are the 3 signs of Hypertension and 4 signs of Malignant Hypertension?

A

Asymptomatic (most common presentation)

Occipital Headaches which are worse in the Morning

Signs of an Underlying Cause

Malignant Hypertension (4)

  • Hypertensive Retinopathy
  • Visual Disturbances
  • Cardiac Symptoms (Chest Pain)
  • Oliguria/ Polyuria
61
Q

What should be offered to all Hypertensive Patients?

A

Ambulatory Blood Pressure Monitoring, or Home Blood Pressure Monitoring if that is contraindicated

62
Q

What is the 5 step management for Hypertension?

A

<55 years old or Type 2 Diabetes Mellitus

  • ACE Inhibitor
  • Add a Calcium Channel Blocker or a Thiazide Diuretc

> 55 years old or Black

  • Calcium Channel Blocker
  • Add an ACE Inhibitor or ARB or Thiazide Diuretic

Then give an ACE Inhibitor, ARB and a Thiazide Diuretic (all three of them)

Then if their Potassium level is more than 4.5, give them a Beta Blocker or an Alpha Blocker
- If their Potassium level is less than 4.5, give them an Aldosterone Antagonist

If treatment doesn’t work, give them a Direct Renin Inhibitor (Aliskiren)- which is similar to an ACE Inhibitor in efficacy

63
Q

What are the 4 complications of Hypertension?

A

4Cs

Coronary Artery Disease
Cerebrovascular Event
Congestive Heart Failure
Chronic Kidney Disease

64
Q

What is the pathophysiology of Infective Endocarditis?

A

It is a condition that occurs as a result of an abnormal endocardium due to a Rheumatic or Congenital Heart Disease, Valvular Pathology or Prosthetic Valves.

This leads to Turbulent Blood Flow and Thrombus Formation

This Thrombus then becomes infected due to bacteria

This bacteria damages the valves

65
Q

What causes Acute and Subacute Infective Endocarditis and what is the appropriate treatment for each bacteria?

A

Acute- occurs Days to Weeks and is caused by Staphylococcus Aureus- Treat this with Rifampicin

Subacute- occurs Weeks to Months and is caused by Streptococcus Viridans- Treat this with Benzylpenicillin

66
Q

What 2 conditions can cause Non-Bacterial Thrombotic Infective Endocarditis (Marantic Infective Endocarditis)?

A

Malignancy or SLE

67
Q

What are the 5 organsims associated with Infective Endocarditis and what conditions are they associated with?

A

Staphylococcus Aureus (the Most Common)

Staphylococcus Epidermis (Indwelling Lines)

Streptococcus Viridans

Steptococcus Bovis (Colon Cancer)

Streptococcus Mitis and Streptococcus Sanguinis (poor Dental Hygiene- after a Dental Procedure)

68
Q

What are the 9 clinical features of Infective Endocarditis?

A

FROM JANE (+ Splenomegaly)

  • Fever/ Chills
  • Roth’s Spots (White-centred Retinal Haemorrhages)
  • Osler’s Nodes (Painful Nodules on Fingers and Toes due to Immune Complex Deposition)
  • Murmurs (with or without evidence of Heart Failure)
  • Janeway Lesions (Painless Plaques due to Septic Emboli)
  • Anaemia
  • Nails (Splinter Haemorrhage)
  • Emboli (Septic Emboli may lead to Joint Pain)

Mild Splenomegaly

69
Q

What 4 investigations should be ordered if Infective Endocarditis is suspected?

A
  • Echocardiogram needed to confirm the diagnosis- First Transthoracic, then Transoesophageal
  • Raised WCC and Neutrophilia
  • ECG- may show a Prolonged PR Interval
  • Urinalysis- Haematuria may be present- due to Glomerulonephritis occuring secondary to the Septic Emboli
70
Q

What is the management for Infective Endocarditis (4)?

A
  • IV Antibiotics (Rifampicin for Staphylococci and Benzylpenicillin for Streptococci)
  • May require Central line or Peripherally inserted Central Catheter
  • Second line- Surgery if (6)- Decompensated Heart Failure, Antibiotic Resistance, Severe Sepsis, Perivalvular Abscess, Intracardiac Fistulae, Prosthetic Valve Endocarditis
71
Q

What are the 3 complications of Infective Endocarditis?

A

Congestive Heart Failure

Septic Embolism- which can result in a Stroke

Aortic Root Abscess- suspect in Aortic Valve Endocarditis that fails to improve within 72 hours of appropriate Antibiotics

72
Q

When is Antibiotic Prophylaxis not recommended in Infective Endocarditis? (4)
As people undergoing these procedures will be receiving antibiotics as well

A

Dental Procedures

Respiratory Tract Procedures

Gastrointestinal Tract Procedures

Genitourinary Procedures (like Childbirth)

73
Q

What do you do if a person at risk of Infective Endocarditis is receiving antibiotics for a Gastrointestinal or Genitourinary Procedure?

A

Offer the Antibiotics for Infective Endocarditis instead

74
Q

What do you do if a person at risk of Infective Endocarditis is undergoing a Dental Procedure?

A

Do NOT offer them Chlorhexidine Mouthwash

75
Q

What is the normal QT Interval range in Males and Females?

A

<430 in Males

<450 in Females

76
Q

What are the 3 congenital causes of Long QT Syndrome (For LQT1, LQT2, LQT3)

A

KCNQ1 (LQT1)
KCNH2 (LQT2)
SCN5A (LQT3)

77
Q

Which Cardiac Drugs (3), Antidepressants (2), Metabolic Conditions (3) and Conditions (4) can cause Long QT Syndrome?

A

Cardiac Drugs- Amiodarone, Procainimide, Sotalol

Antidepressants- SSRIs, Tricyclics

Hypokalaemia, Hypomagnesaemia, Hypocalcaemia

Myocarditis, Myocardial Infarction, Hypothermia, Subarachnoid Haemorrhage

78
Q

What is Romano-Ward Syndrome and Jervell-Lange-Nielsen Syndrome in QT prolongation?

A

Romano-Ward Syndrome- QT prolongation without deafness

Jervell-Lange-Nielsen Syndrome- QT prolongation with deafness

79
Q

What are the 3 types of Long QT Syndrome and what are the associated signs?

A

LQT1- Exertional Syncope (often occurs after Swimming)
LQT2- Syncope following Emotional Stress or Arousal
LQT3- Syncope at Night or at Rest

80
Q

What is the 2 step management for Long QT Syndrome?

A

Beta blockers- Apart from Sotalol, because it is a cause of Long QT Syndrome
(Beta blockers prevent Ventricular Tachyarrhythmias)

ICD (Defibrillation) if (3) they have had a previous Cardiac Arrest or if the Beta blockers are not working or if their QT interval is Above 500

81
Q

When are Right-sided and Left-sided Cardiac Murmurs the Loudest?

A

Right-sided Murmurs are loudest on Inspiration

Left-sided Murmurs are loudest on Expiration

82
Q

What are the 3 common types of Ejection Systolic Murmurs and some facts about each? (3,2,0)

A

Aortic Stenosis

  • It is associated with a Paradoxical S2 Splitting (heard during Expiration)
  • It is associated with the SAD Symptoms (Syncope, Angina, Dyspnoea)
  • It is associated with a Non-Displaced Heaving Apex Beat- which is suggestive of Left-Ventricular Hypertrophy

Hypertrophic Cardiomyopathy

  • It is associated with a Paradoxical S2 Splitting (Heard during Expiration)
  • It is associated with Syncope in Young Men

Pulmonary Stenosis

83
Q

What are the 2 types of Late Systolic Murmurs?

A

Mitral Valve Prolapse (most common)

Tricuspid Prolapse

84
Q

What are the 3 types of Pansystolic Murmurs and some facts about each? (3,3,2)

A

Tricuspid Regurgitation

  • Happens in Infective Endocarditis (secondary to IV Drug Use)
  • There would be Hepatic Pulsations and signs of Right Heart Failure
  • Large V waves in JVP

Mitral Regurgitation

  • Causes (3)- Ischaemic Heart Disease, Rheumatic Fever, Calcification
  • The Apex Beat may be Displaced
  • It radiates to the Axilla

Ventricular-Septal Defect

  • It is a shunt between the Left and Right Ventricles
  • It is associated with (2)- Tetralogy of Fallot and Down’s Syndrome
85
Q

What is the main type of Mid-Systolic Murmur?

A

Atrial-Septal Defect- it is associated with a Fixed Splitting of S2

86
Q

What are the 2 types of Early Diastolic Murmurs and facts about each? (6,1)

A

Aortic Regurgitation

  • Decrescendo
  • Collapsing Pulse
  • The Apex Beat may be displaced (like Mitral Regurgitation)
  • The Distension and Collapse of the Carotid Arteries is Visible
  • There are Visible Pulsations on the Nail Bed when the Nail Bed is Compressed
  • Each Heart Beat is associated with Head Bobbing

Pulmonary Regurgitation
- Commonly due to Pulmonary Hypertension

87
Q

What are the 3 types of Mid-Late Diastolic Murmurs and facts about each? (3,1,1)

A

Mitral Stenosis

  • Signs of Pulmonary Hypertension (Malar Flush, Right-Sternal Heave)
  • Atrial Fibrillation
  • Loudest Over Apex

Tricuspid Stenosis
- Wide-splitting S1

Austin-Flint-
- Severe Aortic Regurgitation

88
Q

What causes a Mid-Late Blowing Diastolic Murmur?

A

Complete Heart Block

89
Q

What 2 investigations should be done if a Murmur is heard?

A

Blood Cultures if the patient is Pyrexial

Echocardiogram to determine Mitral and Aortic Valvular Pathology/ the presence of Pericarditis/ Pericardial Effusion

90
Q

What is the pathophysiology of Rheumatic Fever?

A

An Infection from a bacteria (commonly Streptococcus Pyogenes) following a Pharyngeal Infection typically causes the body to produce antibodies against the Bacterial M Protein

These Antibodies are also complimentary to Cardiac and Joint Tissue

Damage to the valves leads to Rheumatic Heart disease

Histologically Aschoff Bodies are found in Rheumatic Heart Disease

91
Q

What is the demographic for Rheumatic Fever?

A

Typically occurs in 5-17 year olds in the Developing World

92
Q

What are the 7 signs of Rheumatic Fever

A

Sore Throat

Pleuritic Chest Pain

Joint Pain

A Rash that doesn’t itch (Non-Pruritic)

Sydenham’s Chorea

Mitral Regurgitation if Acute, Mitral Stenosis if Chronic

Erythema Marginatum (Pink or Red Macules (flat) or Papules (raised) with a clear centre on the Trunk or Limbs)

93
Q

What is the 3 step management plan for Rheumatic Fever?

A

Benzylpenicillin

Haloperidol or Diazepam if Sydenham’s Chorea is Severe

All patients should be put on Long-Term Antibiotics (Benzylpenicillin)

94
Q

What is the main complication of Rheumatic Fever?

A

Atrial Fibrillation

95
Q

What are the 4 types of Supraventricular Tachycardia?

A

Atrial Fibrillation
Wolff-Parkinson White Syndrome
Paroxysmal Supraventricular Tachycardia
Atrial Flutter

96
Q

What 2 tests should be ordered if Supraventricular Tachycardia is suspected?

A

TFTs- as Hyperthyroidism is a cause of Secondary Supraventricular Tachycardia

U&Es- check for Hyper and Hypokalaemia and Hyper and Hypocalcaemia

97
Q

When should DC Cardioversion be administered in patients with Supraventricular Tachycardia? (4)

A

Shock- Hypotension, Pallor, Sweating, Cold and Clammy Extremities, Confusion or Impaired Consciousness

Syncope

Myocardial Infarction- if they have an Ischaemic Chest Pain or if there is evidence of a Myocardial Infarction on the ECG

Heart Failure- look for a Pulmonary Oedema or Raised JVP

98
Q

What should be done if Supraventricular Tachycardia is seen?

A

The electrolytes should be corrected

Most people do not need treatment

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