Anaesthetics and Intensive Care Medicine (Quesmed) Flashcards

1
Q

What are the 7 causes of Airway Compromise?

A

Angioedema
Anaphylaxis
Thermal injury
Neck Haematoma
Wheeze
Surgical Emphysema
Reduced Consciousness

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2
Q

What is the 4 step approach to Assessing a C-Spine Injury?

A

ABCDE Approach
Full Mobilisation until C-Spine is Cleared
Detailed History and Examination
Imaging as required

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3
Q

What are the 5 NEXUS Criteria needed to determine whether a C-Spine Injury is unlikely?

A

Normal Level of Alertness
No Evidence of Intoxication
No Painful Distracting Injury
No Focal Neurological Injury
Absence of Midline Cervical Tenderness

If all of the above Criteria are met, C-Spine may be cleared and Imaging may not be required

If the C-Spine cannot be cleared clinically, proceed with Imaging (CT, not plain Xrays as Xrays have limited value here)

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4
Q

What is the 4 step management of a C-Spine Injury?

A

Airway management while in full in-line Stabilisation
(Maintain Neutral Neck Position- Do Not use Head Tilt/ Chin Lift Manouevre. Instead use aa Jaw Thrust if Required)

Application of an Appropriately Sized Semi-rigid Collar

Secure Head with Blocks and Tape

Secure patient with full in-line Stabilisation

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5
Q

What signs after a surgery are considered abnormal?

A

Hypotension and Tachycardia are considered abnormal and are a sign of Shock, which may be due to a post-operative bleed

A Mild Pyrexia is common in the 48 hours after a Procedure

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6
Q

What are the 4 signs of a Cluster Headache?

A

A Unilateral headache that is typically worse around the Eye- occuring in Clusters over time

A Bloodshot or Teary Eye

Vomiting

Rhinorrhoea

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7
Q

What are the 2 Risk Factors for a Cluster Headache?

A

Middle Aged Men

Alcohol and Smoking

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8
Q

What is the 2 (2,2) step management of a Cluster Headache?

A

Treatment of a Cluster Headache is with 100% Oxygen and Sumatriptan

Prophylactic Treatment includes Verapamil and Steroids

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9
Q

What is Compartment Syndrome?

A

It most commonly develops after Limb Trauma where Muscle Swelling and Inflammation leads to an Increase in Pressure in the Muscle Compartment

This is a limb-threatening condition that needs to be diagnosed and treated quickly as the increase in pressure can cause a Loss of the Blood Supply to that Limb and Subsequent Ischaemia

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10
Q

What are the 5 signs of Compartment Syndrome?

A

Severe Pain, particularly on the Passive Flexion of the Toes
Pallor
Paralysis of the Limb
Pulselessness
Paraesthesia

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11
Q

What is the 3 step management of Compartment Syndrome?

A

Urgent Fasciotomy

Analgesia

Fluids

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12
Q

What is Delirium tremens?

A

It is a rapid onset of Confusion Precipitated by Alcohol Withdrawal. It usually develops 72 hours after Ceasing Alcohol Intake and can last for several days

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13
Q

What are the 5 signs of Delirium tremens?

A

Confusion
Hallucinations (visual and tactile (such as Formication- sensation of Insects crawling on or under the skin))
Sweating
Hypertension
(Rare) Seizures

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14
Q

What is the 5 step management of Delirium tremens?

A

Chlordiazepoxide
Fluids
Anti-emetics
Pabrinex
Refer to Local Drug and Alcohol Liaison Team

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15
Q

What 7 drugs should be stopped before a Surgery? And how long should they be stopped for?

A
  • Clopidogrel should be stopped 7 days before the surgery
  • Warfarin should be stopped 5 days before the surgery and patients should be on Low Molecular Weight Heparins instead until the Night before
  • ACE Inhibitors should be stopped the day before
  • Insulin should be held on the day of the surgery (only the short-acting preparations)
  • Sulfonylureas should be held on the day of the surgery (due to the risk of Hypoglycaemia)
  • Metformin can be given as normal for Short Procedures. For Longer Procedures, where patients are not Eating or Drinking for several days, Metformin should be held and Variable-rate Insulin should be Prescribed
  • The Pill should be stopped 4-6 weeks before Surgery and restarted at least 2 weeks after Surgery. This reduces the Risk of Deep Vein Thrombosis (DVT)
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16
Q

What is Epidural Anesthesia (where is it injected)? What are the 3 risks? And how is it monitored?

A

It is the injection of a Local Anaesthetic to the Epidural Space around L2-3 or L3-4 at the Vertebral Level

3 Risks-
- Maternal hypotension, which results in Foetal and Maternal Distress
- Risk of Dural Puncture (which results in a severe Postural Headache)
- Epidural Haematoma

Monitoring-
- CTG (Cardiotocography) monitoring of the foetus’ heart rate is recommended.

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17
Q

What are the 7 signs that suggest a patient may require fluid resuscitation?

A

Systolic BP<100mmHg
Heart Rate >90bpm
Capillary Refill>2s
Cool Peripheries
Respiratory Rate>20
NEWS>/=5
Dry Mucous Membranes

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18
Q

What is the 4 step approach to Fluid Resuscitation?

A

Identify the cause of Fluid Deficit and respond appropriately

Fluid bolus of 500ml Crystalloid over<15 minutes

Reassess using ABCDE Approach

Further Fluid Boluses (up to 2,000ml) may be required

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19
Q

What are the 5 daily fluid requirements?

A

25-30mL/kg/ day of Water
1 mmol/kg/day of Sodium
1 mmol/kg/day of Potassium
1 mmol/kg/day of Chloride
50-100g/ day of Glucose to limit Ketosis

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20
Q

What are Crystalloid and Colloid Fluids?

A

Crystalloid Fluid- Solution containing small molecules (Sodium, Chloride)

Colloid Fluid- Solution containing larger molecules (Albumin)

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21
Q

What is the composition of 0.9% Sodium Chloride (Saline) Fluid, 0.18% Sodium Chloride/ 4% Glucose, 0.45% Sodium Chloride/ 4% Glucose, 5% Dextrose and Hartmann’s?

A

0.9% Sodium Chloride-
- 154mmol/L of Sodium and 154%mmol/L of Chloride

0.18% Sodium Chloride/ 4% Glucose-
- 31mmol/L of Sodium, 31mmol/L of Chloride and 222mmol/L Glucose

0.45% of Sodium Chloride/ 4% Glucose-
- 77mmol/L of Sodium, 77mool/L of Chloride and 222mmol/L Glucose

5% Dextrose-
- 278mmol/L Glucose

Hartmann’s-
- 131mmol/L of Sodium, 5mmol/L of Potassium, 111mmol/L of Chloride and 29mmol/L of HCO3-

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22
Q

What are the 4 types of Fluid suitable for Resuscitation and which 2 should not be used for Resuscitation and why?

A

Suitable
- Saline (0.9% NaCl)
- Hartmann’s Solution
- 4-5% Human Albumin Solution- if Severe Sepsis
- Blood- if Severe Haemorrhage

Fluids not suitable for Resuscitation-
- Dextrose (Does not stay in the Intravascular Compartment)
- Gelofusine (Risk of Anaphylaxis)

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23
Q

What is the 4 step approach to using Fluids to Resuscitate patients?

A

Use 500ml of the Fluid of Choice, or 250ml if Cardiac Disease or if the patient is Old (due to the Increased Risk of Pulmonary Oedema secondary to Excessive Fluid Resuscitation)

This should be given over <15 minutes

This can be repeated if Needed

If the patient fails to respond after 2L of Fluid, they should be considered Non-Fluid Responsive and immediate help should be sought (they may require Blood Pressure Support)

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24
Q

What is Lactic Acidosis seen as in an ABG?

A

Raised Anion Gap, Metabolic Acidosis

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25
Q

What are the 7 causes of Type A (Tissue Hypoxia) and 5 causes of Type B (Abnormalities in the Metabolism of Lactate) Lactic Acidosis?

A

Type A-
- Shock
- Hypoxia
- Acute Mesenteric Ischaemia
- Limb Ischaemia
- Severe Anaemia
- Seizures
- Vigorous Exercise

Type B-
- Diabetic Ketoacidosis
- Cancer
- Liver Disease
- Inborn Errors in Metabolism
- Drugs (Metformin (impairs liver metabolism of Lactate) and Aspirin)

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26
Q

What are the 16 signs of Local Anaesthesia Toxicity?

A

Hypotension
Hypertension

Tachycardia
Sinus Bradycardia
Ventricular Arrhythmias
Asystole

Shivering
Tinnitus
Subtle Tremors of Face and Extremities
Restlessness and Agitation
Seizures
Numbness or Tingling around the Mouth

Vertigo and Dizziness
Decreased Consciousness

Respiratory Depression
Apnoea

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27
Q

What is the 5 step management of Local Anaesthesia Toxicity?

A

Stop administering the Local Anaesthetic

ABCDE approach including the ECG monitoring

Lipid Emulsion (20% Intralipid) 1ml/kg every 3 minutes up to a dose of 3mL/kg

Initiate Lipid Emulsion Infusion at a rate of 0.25ml/kg/min

Maximum Dose= 8ml/kg

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28
Q

What is the most common cause of Malignant Hyperthermia and what are the 2 triggers of this condition?

A

An Autosomal Dominant Mutation in the Ryanodine Receptor 1- which increases Calcium Levels in the Sarcoplasmic Reticulum and Increases Metabolic Rate- so it is Diagnosed by GENETIC Testing

Triggered by- Inhalation of Anaesthetics or Suxamethonium

29
Q

How is Malignant Hyperthermia managed?

A

Stop the triggering agent

Administer Intravenous Dantrolene (Ryanodine Receptor Antagonist)

Restore Normothermia

30
Q

What are the 8 signs of a Skull Fracture?

A

Subcutaneous Haematoma
Subcutaneous Haematoma around the eyes (Raccoon Eyes)
Subcutaneous Haematoma behind the ears (Battle Sign)

Subcutaneous Emphysema

CSF Rhinorrhoea
CSF Otorrhoea

Haemotympanum

Cranial Nerve Palsies- Arise 1-3 days after the Trauma

31
Q

What is the first line investigation of Head Trauma and what 3 other investigations should be ordered?

A

CT Head

Other-
- CT Cervical Spine (look for Spinal Fractures)
- CT Angiogram (look for Local Vascular Injury)
- Plain Skull Xray (assess for Orbital Fracture)

32
Q

What 2 interventions are contraindicated in a Skull Fracture?

A

Nasopharyngeal Airways (as this can cause further damage to the patient)

Head tilt Chin lift (contraindicated if patient is at risk of C-Spine Injury)

33
Q

What is the pathophysiology of Medication Overuse Headaches?

A

Occurs due to the Down-regulation of Pain receptors-leading to the lack of efficacy of Analgesics when they are used

34
Q

What are the 2 commonly used methods of confirming NG Tube placement?

A

1) Measuring the pH of the NG Tube Aspirate (Gastric Content has a pH of 1.5-3.5, so a pH less than 5 is enough to confirm Gastric Placement

2) Erect Chest Xray to confirm the NG Tube traverses inferiorly down the midline, bisects the Carina and the tip is below the Diaphragm. The tip should be 10cm below the gastrooesophageal junction

35
Q

What is CPAP and BiPAP?

A

CPAP is a form of Noninvasive ventilation used in patients with Type 1 Respiratory Failure- providing Positive Pressure to keep the Alveoli open for a longer period of time to facilitate Gas Exchange

BiPAP is used in patients with Type 2 Respiratory Failures, with 2 different levels of Positive Pressure on Inspiration AND Expiration

36
Q

What are the 3 Inclusion Criteria for starting Noninvasive Ventilation?

A

Patient awake and able to protect airway

Cooperative Patient

Consideration of Quality of Life of Patient

37
Q

What are the 6 contraindications for starting Noninvasive Ventilation?

A

Facial burns

Vomiting

Untreated Pneumothorax

Severe Comorbidities

Haemodynamically unstable

Patient refusal

38
Q

What are the 7 causes of Anaemia?

A

Iron Deficiency (most common)

Vitamin B12 or Folate Deficiency

Renal Failure

Malignancy

Menorrhagia

Anaemia of Chronic Disease

Drugs (chemotherapy agents)

39
Q

What are the 5 pre-operative and 3 post-operative managements of Anaemia?

A

Preoperative management-

  • Oral iron if >6 weeks until planned surgery
  • IV iron if <6 weeks until planned surgery
  • B12/Folate replacement
  • Erythropoeisis-Stimulating Agent (ESA) Therapy
  • Transfusion if Profound Anaemia and Surgery cannot be delayed

Postoperative management-

  • Transfusion
  • IV Iron
  • Oral Iron
40
Q

Why do patients on Steroids need their doses changed peri-operatively?

A

When the body experiences Acute Stress (illness, trauma and surgery), its steroid demand increases

Patients on long term steroids cannot respond to this demand as their adrenal function is suppressed

41
Q

What is the 3 step peri-operative management of patients on steroids?

A

Switch Oral Steroids to 50-100mg IV Hydrocortisone

If there is an associated Hypotension, Fludrocortisone can be added

For minor operations, Oral Prednisolone can be restarted immediately post-operatively. If the surgery is major then they may require IV Hydrocortisone for up to 72 hours post-operatively

42
Q

What is the 3 step Peri-operative management of Non-insulin Dependent Diabetics?

A

Hold all Oral Diabetic medications on the morning of the procedure

If the patient is on Insulin, switch to Sliding Scale Infusion (restart when they can eat)

Restart all Oral Medications the morning after surgery

For some operations, Metformin does not need to be stopped, but consider the risk of Lactic Acidosis

43
Q

What is the 5 step Peri-operative management of Insulin-Dependent Diabetes?

A

Put the patient as early on the theatre list as possible to minimise the amount of time they are Nil By Mouth

If they are on Long-acting Insulin, continue this but at a reduced level (reduced by 20%)

Stop any other insulin and begin Sliding Scale Insulin Infusion from when the patient is Nil By Mouth

Continue Infusion until patient is able to eat Post-operatively

Switch to Normal Insulin Regimen around their First Meal

44
Q

What are the 5 causes of Post-operative Nausea and Vomiting?

A

Infection

Hypovolaemia

Pain

Paralytic Ileus

Drugs

45
Q

What are the 3 Non-pharmacological and 3 Pharmacological management approaches to Post-operative Nausea and Vomiting?

A

Non-pharmacological-
- Minimise patient movement
- Analgesia
- IV Fluids if Dehydrated

Pharmacological-
- 5HT3 Receptor Antagonist (Ondansetron- first line)- Risk of QT Prolongation and Constipation
- Histamine (H1) Receptor Antagonist (Cyclizine)- Avoid in Severe Heart Failure
- Dopamine (D2) Receptor Antagonist (Prochlorperazine)- Risk of Extrapyramidal Side Effects (Dystonic Reactions)

Other Antiemetics such as Corticosteroids and Metoclopramide are reserved for specific cases of Post-operative Nausea and Vomiting

46
Q

What are the 3 Pre-renal, 1 Renal and 5 Post-renal causes of Poor Urine Output?

A

Pre-renal-
- Hypovolemia
- Hypotension
- Dehydration

Renal-
- Acute Tubular Necrosis

Post-renal-
- Benign Prostate Hypertrophy
- Anticholinergic or Alpha Adrenoceptor Antagonist Drugs (Commonly used in Anaesthetics)
- Pain (particularly Hernia Operations)
- Psychological Inhibition
- Opiate Analgesia

47
Q

What is Rapid Sequence Induction?

A

It is the method of coordinating the administration of Rapid Acting Induction Agents to produce analgesia and muscle relaxation

Followed by Prompt Intubation, this results in a Secure Airway with a minimal risk of Aspiration

48
Q

What are the 5 roles of Rapid Sequence Induction?

A

Airway
Drug Preparation
Monitoring of Vital Signs
Drug Administration
Cricoid Pressure

49
Q

What are the 7 steps of Rapid Sequence Induction (7 Ps)

A

Preparation- Environment is optimised, Equipment is available, Staff are ready

Preoxygenation- Administration of high flow oxygen for 5 minutes before the procedure

Pretreatment- Administration of Opiate Analgesia or a Fluid Bolus to Counteract the Hypotensive effect of the Analgesia

Paralysis- Administration of the Induction Agent (Propofol or Sodium Thiopentone) and a Paralysing Agent (Suxamethonium or Recuronium)

Protection and Positioning (Cricoid Pressure should be applied following paralysis) In line Stabilisation may be required in some cases

Placement and Proof- Intubation is performed via Laryngoscopy with Proof Obtained (Direct Vision, End tidal CO2, Bilateral Auscultation)

Post-intubation Management- Taping or Tying the Endotracheal Tube, initiating mechanical ventilation and sedation agents

50
Q

What is Suxamethonium Apnoea?

A

Occurs in people who have a defect in the Plasma Cholinesterase enzyme which normally breaks down Suxamethonium. These individuals have a prolonged period of paralysis following Suxamethonium Injection

51
Q

How is Systemic Inflammatory Response Syndrome diagnosed?

A

More than one of:

  • Temperature> 38C or <36C
  • Heart Rate>90
  • Respiratory Rate>20
  • White Cell Count> 12 or <4
52
Q

What is Sepsis and Septic Shock?

A

Sepsis- Systemic Inflammatory Response Syndrome (SIRS) plus Infection

Septic Shock- Sepsis with a systolic BP<90mmHg that is NOT Responsive to Fluids- they need URGENT Intensive Care Referral

53
Q

What are the 8 signs of Skull Fracture?

A

Subcutaneous Haematoma
CSF Rhinorrhoea
CSF Otorrhoea
Subcutaneous Haematoma around the Eyes- Raccoon Eyes
Haemotympanum
Subcutaneous Haematoma behind the Ears- Battle Sign
Subcutaneous Emphysema
Cranial Nerve Palsies- 1-3 days after the Trauma

54
Q

What 2 Interventions are contraindicated in a Skull Fracture?

A

Nasopharyngeal Airways

Head tilt chin lift is contraindicated in these patients

55
Q

What 2 Investigations should be ordered in Head Trauma?

A

First line is plain CT Head

Other imaging can include CT Cervical Spine for Spinal Fractures. CT Angiogram (looking for Local Vascular Injury) and plain Skull Xray (assessing for Orbital Fractures)

56
Q

What are the 8 signs of Tricyclic Antidepressant overdose?

A

Drowsiness
Confusion
Arrhythmia
Seizures
Vomiting
Headache
Flushing
Dilated Pupils

57
Q

What 6 Investigations should be ordered if Tricyclic Antidepressant Overdose is suspected?

A

FBC
U&Es
CRP
LFTs
Venous Blood Gases- look for signs of Acidosis
ECG- QT Prolongation

58
Q

What is the 2 step management of Tricyclic Antidepressant Overdose?

A

Activated Charcoal can be given within 2-4 hours of the Overdose

Patients should be reviewed by Intensive Care if there are any concerns about their airway (particularly in drowsy patients) or if they have severe metabolic acidosis that may mean they require Renal Replacement Therapy

59
Q

What can trigger Trigeminal Neuralgia and what can be seen in Neurological Examination?

A

Triggered by light touch, eating or even wind blowing

Neurological examination in these patients is normal and pain MAY be triggered by lightly touching the patient’s face

60
Q

What are the 5 causes of Trigeminal Neuralgia?

A

Malignancy
Arteriovenous Malformations
Multiple Sclerosis
Lyme Disease
Sarcoidosis

61
Q

What is the management of Trigeminal Neuralgia? (6)

A

Medical Treatment-
- Carbamazepine (first line)
- Phenytoin
- Lamotrigine
- Gabapentin

Surgical Treatment-
- Microvascular Decompression
- Treatment of Underlying Cause and Alcohol Injections

62
Q

What is Type 1 Respiratory Failure and what are 3 facts about it?

A

When there is a low PaO2 (<8kPa) with or without a LOW PaCO2

  • The damaged lung tissue limits the oxygenation of the blood which results in Hypoxaemia and Hypoxia. The normal lung tissue that is unaffected is still able to maintain the excretion of carbon dioxide however
  • The 2 step management for Type 1 Respiratory Failure is Prescribing Supplemental Oxygen/ CPAP and correcting the underlying cause
  • If the patient is on Supplemental Oxygen, PaO2 may be normal, but inappropriately low for the Fraction of Inspired Oxygen (FiO2)
63
Q

What are the 6 main causes of Type 1 Respiratory Failure?

A

Decreased Atmospheric Pressure
Ventilation-Perfusion Mismatch
Shunt
Pneumonia
ARDS
Pulmonary Embolism

64
Q

What is Type 2 Respiratory Failure and what causes it (the pathophysiology)?

A

Low PaO2 and High PaCO2

Inadequate Alveolar Ventilation occurs due to failure in the Respiratory Pump and increased Ventilatory Resistance of the Entire Lungs- not Just the Lung Tissue

65
Q

What are the 8 causes of Type 2 Respiratory Failure?

A

Chronic Obstructive Pulmonary Disorder (COPD)
Chest Wall Deformity (Kyphosis and Scoliosis)
Central Nervous System Depression due to Opioids or Sedatives
Severe Asthma
Myasthenia Gravis
Guillain-Barre Syndrome
Obesity
Respiratory Distress Syndrome

66
Q

What are the 6 clinical features of Hypercapnia (seen in Type 2 Respiratory Failure)?

A

Headache
Altered Level of Consciousness
Warm Extremities
Behavioural Change
Asterexis
Papilloedema

67
Q

What 4 investigations should be ordered in Type 2 Respiratory Failure?

A

Arterial Blood Gas (PaCO2>6kPa, PaO2<8kPa)
Pulse Oximetry (Measure Oxygen Saturation)
Simple Spirometry (Measure Tidal Volume and Vital Capacity)
Electrocardiogram (look for Cardiac Arrhythmias secondary to Hypoxaemia and Acidosis)

68
Q

How is Type 2 Respiratory Failure managed? (4)

A

Treat the Underlying Pathology
Supplemental Oxygen via Nasal Canula, Face Mask, Venturi Mask or Non-rebreather Mask
Non-invasive Ventilation (CPAP or BiPAP)
Invasive Ventilation (Endotracheal Tube or a Tracheostomy)

(Also remember an Excessive Administration of Oxygen can lead to the reversal of Hypoxic Vasoconstriction. More Pulmonary Blood Flow is directed to Poorly Ventilated Alveoli, which exacerbates the Ventilation/Perfusion Mismatch as a result. Therefore the target SpO2 in patients with Severe Hypercapnic Respiratory Failure is 88-92%)