Cardiology Flashcards
What does a sarcomere consist of?
Actin and myosin
Contractions depend on
Calcium and ATP
How does the cross bridge form?
Calcium binds to troponin, cause the tropomyosin complex to move and unblock cross-bridge site on actin
Myosin then can bind to actin
Stroke volume is what?
Volume per beat
EDV-ESV
What is the main principle of FS curve?
Greater EDV, greater SV
CO =
SVxHR
Ionic channels in pacemaker
Phase 4
Phase 0
Phase 3
HCN (funny current), T-calcium
L-calcium
K voltage gated
S1 is due to
AV valves closing = systole
S2 is due to
Semilunar valves closing = diastole
What is a dicrotic notch?
Vibration when valve is closing
Diastolic lasts for
Systolic lasts for
- 5s
0. 3s
ECHO is diagnostic test for
Murmur, endocarditis
1st degree heart block
PR > 0.2
Angina is caused by
Restricted blood flow due to atherosclerosis
Unstable vs stable angina
Unstable - pain at rest
Stable - pain on exertion
Treatment of angina
GTN –> prophylaxis (BB, ivabradine, CCB) –> surgery
How is MI diagnosed?
Troponin and ECG
Troponin detects what?
Myocardial necrosis
Treat MI
MONA+C Morphine Oxygen Nitrates (GTN) Aspirin Clopidegrol
What is Dressler’s syndrome?
ECG feature?
Post-MI pericarditis
Saddle shaped ST elevation
Left heart failure is due to
Low CO from left side of heart
Diagnosis of LVF
NP test, echo, ecg
Treat LVF long term
Lifestyle, loop, ACEi, BB
Acute LVF treatment
Sit up, oxygen, IV loop, IV morphine
Dilated cardiomyopathy is caused by
Alcohol, chemo, infection