Cardiology Flashcards
Causes of dilated cardiomyopathy (4)
- Idiopathic
- Infections (viral)
- Alcohol or drug abuse
- Metabolic, vitamin B1 deficiency
Standard systolic heart failure treatment
ACE inhibitors
Beta blockers (metoprolol or carvedilol)
Symptom control with diuretics
Takotsubo cardiomyopathy
Transient regional systolic dysfunction of the LV that can imitate an MI but is associated with absence of significant obstructive CAD or evidence of plaque rupture, often seen in post menopausal women exposed to physical or emotional stress thought to be due to possible catecholamine surge, WILL see EKG findings such as ST elevations in 3 consecutive leads and cardiac enzymes are often positive, but coronary angiography shows absence of plaque rupture or obstruction
Most common cause of restrictive cardiomyopathy
Amyloidosis, sarcoidosis, hemochromatosis, metastatic disease
Kussmaul’s sign
Lack of inspiratory decline or increase in JVP with inspiration, normally inspiration causes JVP to drop because blood gets sucked in
Definitive diagnosis of restrictive cardiomyopathy is made through ___. Often an ___ is the diagnostic test of choice
Endomyocardial biopsy, echocardiogram
Hypertrophic cardiomyopathy has systolic or diastolic dysfunction?
Diastolic dysfunction, becomes stiff and unable to relax
All murmurs except HOCM do what with increased venous return (squat, supine, leg raise) or increased afterload (grip)?
Increased loudness
HOCM does what with increased venous return?
Decrease loudness
What virus is most likely to cause myocarditis?
Coxsackievirus B
Rate determination pattern of an EKG if regular rhythm
300 150 100 75 60 50
Axis of an EKG is determined by these 2 leads
Lead 1 and AVF
Left bundle branch block on EKG
Wide QRS***, broad slurred R in V5 or V6
Right bundle branch block on EKG
Wide QRS***, RsR’ in V1 or V2
Pathologic Q wave definition
A Q wave >1 box in depth or width
3 things that, if present in 2 consecutive leads, indicates heart damage
- Pathologic Q waves
- ST depression or elevation
- T wave inversion
Anterior wall infarction corresponding leads and artery involved
V1-V4, LAD
Lateral wall infarction corresponding leads and artery involved
I, AVL, V5, V6, circumflex
Inferior wall infarction corresponding leads and artery involved
II, III, AVF, RCA
What are the 2 nondihydropyridine ca2+ channel blockers
Verapamil
Diltiazem
1st line pharmacologic for WPW (narrow complex tachyarrhythmia)
Procainamide, opposed to adenosine which is used in others
Unstable bradycardia pharmacologic agent of choice
Atropine .5mg bolus every 3-5 min max at 3mg then dopamine if that doesn’t work
Unstable tachycardia treatment
Immediate synchronized cardioversion
Stable tachycardia treatment
12 lead ekg to assess QRS width, vagal maneuvers
Afib first line pharmacologic option
Beta blocker or Ca2+ channel blocker
Narrow QRS stable tachycardia treatment (excluding wpw)
Adenosine 6mg iv push
Wide QRS stable tachycardia treatment
Amiodarone 150mg
Acute coronary syndrome ACLS steps
- oxygen 94-95%
- IV access
- 12 lead EKG
- 325 mg chewed aspirin unless recent GI bleed or allergy
- Sublingual nitro (unless BP low, which it may be in the situation of RV infarct, or PDE5 use)
- Morphine
- Notify cath lab (if cannot then tPA in 30 min of arrival)
- CXR
- Troponin
Stroke ACLS steps
- Facial droop, arm drift, or slurred speech (cincinnati stroke scale)
- Find last known normal
- Supportive care
- CT
- Perform NIH scale assessmet
- Ischemic qualities and within 3 hours last known normal tPA fibrolytic therapy
- Ischemic qualities and non qualifying then aspirin
If AED says shockable, what 2 rhythms could it be?
Ventricular fib
Pulseless Vtach
If AED says non shockable, what 2 rhythms could it be?
Asystole
PEA
Ventricular fib or pulseless Vtach steps
- administer shock
- CPR 2 min
- shockable?
- If yes cpr 2 min +1 mg epi every 3-5 min IV/IO
Asystole/PEA steps
- CPR 2 min
- 1 mg epi every 3-5 min IV/IO
- shockable?
- If no check for signs of ROSC
You should get an AED if alone with a down adult, but with a kid, you should start ___ first
CPR 2 min
Most common cause of sick sinus syndrome (tachy brady sydnrome)
Sinus node fibrosis
1st degree AV block
Prolonged PR interval, often normal variant asymptomatic in most cases, no treatment needed unless symptomatic then atropine or possibly pacemaker long term
2nd degree AV block Mobitz I
Progressive PR interval lenghtening followed by a dropped QRS (wenckebach), no treatment needed in asymptomatic but can do atropine in symptomatic cases
2nd degree AV block Mobitz II
Constant PR interval with a dropped QRS, often needs treatment because progression to 3rd degree AV block common so permanent pacemaker definitive treatment***
3rd degree AV block
AV dissociation from atrial impulses, requires transcutaneous pacing followed by permanent pacemaker
Treatment of unstable atrial flutter/afib
Direct (synchronized) cardioversion (after TEE to ensure no atrial clots preferrably)
3 novel oral anticoagulants
- rivaroxaban (xarelto)
- dabigatran (pradaxa)
- apixiban (eliquis)
CHA2DS2-VASc criteria
Congestive heart failure Hypertension Age >75 years (2 points) Diabetes Stroke or TIA history (2 points) Vascular disease Age 65-74 Sex (female)
> or = 2 moderate to high risk so chronic oral anticoag recommended
Therapeutic INR goal for warfarin in patients with afib
2-3
PVC definition
Premature beat originating from ventricle causing wide bizarre QRS occurring earlier than expected, common finding on EKG that doesn’t usually warrant treatment unless 3 or > in a row then considered ventricular tachycardi
Torsades de pointes treatment
IV Mag sulfate
Difference between vtach and vfib
V tach still has a pattern while erratic is characteristic of coarse v fib
Long term use adverse effects of aiodarone
Thyroid disorders, pulmonary fibrosis, increased LFTS
Drug used to close a patent ductus arteriosus
IV indomethacin
Drug used to maintain ductus arteriosus and keep it open
Alprostadil
Still murmur
Most common pediatric innocent murmur heard up to preadolesence, cooing like a dove or musical/twanging in nature
Cervical venous hum
2nd most common pediatric innocent murmur behind a stills murmur, most common continuous benign murmur due to turbulent blood flow returning to heart at junction between jugular vein and superior vena cava
How does a patent foramen ovale present?
Often asymptomatic entire life unless causes cryptogenic stroke, treated with surgical PFO closure
Most common type of atrial septal defect
Ostium secundum
Eisenmenger syndrome
Pulmonary hypertension and cyanotic heart disease occurring when a left to right shunt becomes a right to left shunt causing the patient to develop cyanosis and clubbing in lower extremities
Patent ductus arteriosus murmur description
Continuous machine like murmur in the pulmonic area
Physical exam findings of coarctation of aorta
Ankle Brachial index, upper extremitiy hypertension and lower extremity hypotension, delayed or diminished lower extremity pulses
Confirmatory test for coarctation of aorta
Echocardiogram
Study of choice to diagnose tetralogy of fallot
Echocardiogram
Tetralogy of fallot CXR finding
Boot shaped heart
4 components of tetralogy of fallot
RV outflow obstruction
RVH
VSD
Overriding aorta
Most common type of congenital heart disease in childhood
VSD
Diagnostic study for a VSD
Echocardiogram
Biggest risk factor for CAD
DM
4 drugs used in outpatient treatment of angina pectoris
- aspirin
- b blockers
- sublingual nitro
- daily statin
Indications for coronary artery bypass graft
-Left main coronary artery stenosis, or 3 vessel disesae
2 cariac markers most often ordered for ACS
CK-MB
Troponin
Triad of right ventricular infarct
- Increased JVP
- Clear lungs
- Positive Kussmaul sign
ST elevations in inferior leads should indicate a…
…right sided EKG
Cooronary vasospasm treatment
Ca2+ channel blockers, avoid B blockers!!!
Most common cause of HF
CAD (post MI)
BNP > __ inidcates CHF
100
Most common cause of right sided heart failure
Left sided heart failure
Hydralazine
Vasodilator used to treat hypertension
Hydroxyzine
1st gen antihistamine used for anxiety, allergies, vomiting, and anesthesia (sedation)
ACE inhibitors/ARBS do what to k+?
Can precipitate hyperkalemia
Spirinolactone and other k+ sparing diuretics do what to k+?
Can precipitate hyperkalemia
Loop diuretics side effects
Can cause decreased electrolytes, hyperuricemia (precipitate gout), hyperglycemia
Most effective medications that decrease mortality in heart failure with reduced EF? what medications have no mortality benefit?
#1 ACE inhibitors B blockers
Ca2+ channel blockers
CXR findings associtaed with congestive HF
Kerley B lines
Most common secondary cause of hypertension?
Renal artery stenosis
Most common cause of end stage renal disease in the US
Diabetes
Why is it recommended to limit beta blocker use in diabetic patients?
It may mask tachycardic symptoms of hypoglycemia in DM
Drug used to treat hypertension + BPH
Prazosin, doxazosin
Hypertensive urgency and emergency definition
SBP >180 and or DBP >120 without evidence of end organ damage and with evidence of end organ damage respectively
Hypertensive urgency treatments (2)
clonidine
Captopril
Hypertensive emergency treatment
sodium nitroprusside
What’s part of the work up for postural hypotension
tilt table test
What is the only type of shock which agressive IV fluids are NOT given?
Cardiogenic
Massive PE finding on EKG
S1Q3T3
SIRS criteria
2 of the following
- temp >100.4 or <96.8
- Pulse >90bpm
- RR >20
- WBC >12,000
How long should a patient be observed after anaphylactic shock episode
4-6 hours in case of biphasic phenomenon
Best meds to lower LDL, triglcyerides, increase HDL
statins, fibrates, niacin
Statin contraindication
Pregnancy or breastfeeding
Most common valve to become infected NOT from IV drug use?
Mitral valve
Most common valve to become infected from IV drug use
Tricsupid valve
Strep viridans can cause infective endocarditis from dissemination during a….
….dental procedure (patient’s with dental caries)
What are HACEK organisms?
Haemophilus aphrophilus, actinobacillus, cardiobacterium homminis, Eikenella corrodens, Kingella kingae, gram negative organisms that are hard to culture and should be suspected in patients with endocarditis but NEGATIVE blood cultures
3 key physical exam findings in infective endocarditis
- Osler nodes - painful or tender nodules on pads of digits and the palms
- Janeway lesions - painless erythematous macules on palms and soles
- Roth spots - retinal hemorrhages with central clearing
Diagnositc studies for infective endocarditis
- Blood cultures (before antibiotic initiation) 3 sets 1 hour apart each
- Echocardiogram
Modified Duke Criteria
Determines clincial criteria for infective endocarditis, includes 2 major criteria (sustained bacteremia in 2 + cultures) or Endocardial invovlement documented by + eechocardiogram and 5 minor criteria including fever, predisposing condition, vascular and embolic phenomena such as janeway lesions, immunologic phenomena, requires 2 major or 1 major + 3 minor or 5 minor criteria
If antibiotics cannot clear an infected prosthetic heart valve, then what is needed to treat?
Surgery to remove and replace the infected artificial valve
Infective endocarditis native valve treatment
Nafcillin or Oxacillin plus either ceftriaxone or gentamicin
Infective endocarditis prosthetic valve treatment
Vancomycin + gentamicin + rifampin
Regimen for endocarditis prophylaxis in patients that have conditions that warrant prophylaxis
Amoxicillin
Clindamycin
Dressler syndrome is treated different from acute pericarditis how?
Use of aspirin or colchicine but avoid NSAIDS as this may interfere with myocardial scar formation
Pulsus paradoxus
Exaggerated decrease in systolic blood pressure with inspiration seen in cardiac tamponade
Increasing venous return does what to all murmurs except HOCM?
Increases intensity
What increases venous return (3)
Supine position
Squatting
Leg elevation
What decreases venous return (2)
Standing
Valsalva
Inspiration increases intensity of (right or left) sided murmurs? What about the other side?
Right, decreases
What does handgrip do to the outflow?
Decreases it, thus decreasing an outflow murmur (AS or HOCM)
What 3 murmurs increase with handgrip?
Aortic regurg or Mitral regurg or mitral stenosis
Diastolic blowing decrescendo murmur heard at the left upper sternal border
Aortic regurgitation
Quincke’s pulse and interpretation
Fingernail bed pulsations, Aortic regurg
De Musset’s sign and interpretation
Head bobbing with each heart beat, aortic regurg
Watter hammer/corrigan’s pulse and interpration
Swift upstroke and rapid fall of radial and carotid pulse, respectively, aortic regurg
Most common cause of mitral stenosis
Rheumatic heart disease
Opening snap indicates…
…forceful closure of mitral valve, mitral stenosis
Management of mitral stenosis in a younger patient with symptoms?
Percutaneous balloon valvuloplasty
Blowing holosystolic murmur heard best at the apex with radiation to the axilla
Mitral regurg
Most common cause of mitral regurgitation
Mitral valve prolapse
Mid late systolic ejection click
Mitral valve prolapse
Pulmonic stenosis etiologies
Almost always congenital and disease of the young!!!
Pulmonic stenosis treatment
Balloon valvuloplasty
Pulmonic regurgitation causes
Almost always congenital, most clinically insignificant, well tolerated
Mid diastolic murmur at the left lower sternal border
Tricuspid stenosis
Holosystolic, blowing, high pitched murmur at the subxyphoid area, left mid sternal border
Tricuspid regurgitation
Carvallo’s sign
Increased murmur intensity with inspiration distinguishing tricuspid regurgitation from mitral regurgitation
Most common site of AAA formation and main modifiable risk factor
Infrarenal, smoking
AAA diagnosis if stable and symptomatic? If unstable?
CT scan with IV contrast, bedside ultrasound
AAA initial test in asympomtatic patients
Abdominal ultrasound
How is AAA screened for?
1 time abdominal ultrasound inmen 65-75 who have ever smoked
What size of AAA requires surgery
> or =5.5 cm or >0.5 cm expansion in 6 months
Aortic dissection can be split into 2 categories, type A and type B. What is the difference between them and how are they managed?
Type A is the ascending aorta, B involves the descending aorta, type A requires surgery while type B can have medical management
ABI is considered positive for PAD if value is < or =
.90
First line therapy for peripheral artery disease?
Exercise
Most common primary cardiac tumor that can mimick mitral stenosis
Atrial myxoma, identified with TEE as pedunculated mass with ball valve obstruction and requires surgical removal
Giant cell arteritis treatment
HIGH dose corticosteroids
Trousseau sign in superficial thrombophlebitis
Migratory thrombophlebitis associated with malignancy
In a patient with MODERATE risk for DVT, positive D dimer but negative initial ultrasound, what is recommended?
Serial ultrasounds
DVT treatment
Anticoagulation with lovenox plus warfarin, or other anticoagulants, if recurrent can to an IVC filter, or thrombectomy in severe cases
Heparin antidote
Protamine sulfate
Treatment for kawasaki disease (2)
IVIG and high dose aspirin, even in children
Contraindications to aspirin
Renal injury
Gastric mucosal injury
Children use (post viral reye’s sydrome)
Aspirin overdose treatment (2)
IV sodium bicarb and activated charcoal to prevent absorption